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Home > Products > 117 002

IP3-receptor type1 antibody - 117 002

IP3-receptor triggers the release of Ca2+ from intracellular stores
Rabbit polyclonal antiserum
Cat. No.: 117 002
Amount: 200 µl
Price: $355.00
Cat. No. 117 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) (see remarks) gallery  
IP: not tested yet
ICC: not tested yet
IHC: not tested yet
IHC-P: 1 : 100 gallery  
Immunogen Synthetic peptide corresponding to AA 2731 to 2749 from rat IP3-receptortype1 (UniProt Id: P29994)
Reactivity Reacts with: human (Q14643), rat (P29994), mouse (P11881), cow.
Other species not tested yet.
Matching control protein/peptide 117-0P
Remarks

WB: Due to its large size, IP3 receptor requires special gel-electrophoresis and Western blot protocols for visualization by immunoblotting. Excellent results can be obtained with the 4-12% TRIS-glycine gradient gels from anamed or NuPAGE 3-8% TRIS-Acetate gradient gels from invitrogen.
Data sheet 117_002.pdf

References for IP3-receptor type1 - 117 002

The IP3 R Binding Protein Released With Inositol 1,4,5-Trisphosphate Is Expressed in Rodent Reproductive Tissue and Spermatozoa.
Borth H, Weber N, Meyer D, Wartenberg A, Arlt E, Zierler S, Breit A, Wennemuth G, Gudermann T, Boekhoff I
Journal of cellular physiology (2016) 2315: 1114-29. 117 002 WB
The proteome of the presynaptic active zone: from docked synaptic vesicles to adhesion molecules and maxi-channels.
Morciano M, Beckhaus T, Karas M, Zimmermann H, Volknandt W
Journal of neurochemistry (2009) 1083: 662-75. 117 002 WB
Cat. No.: 117 002
Amount: 200 µl
Price: $355.00
The IP3 R Binding Protein Released With Inositol 1,4,5-Trisphosphate Is Expressed in Rodent Reproductive Tissue and Spermatozoa.
Borth H, Weber N, Meyer D, Wartenberg A, Arlt E, Zierler S, Breit A, Wennemuth G, Gudermann T, Boekhoff I
Journal of cellular physiology (2016) 2315: 1114-29. 117 002 WB
The proteome of the presynaptic active zone: from docked synaptic vesicles to adhesion molecules and maxi-channels.
Morciano M, Beckhaus T, Karas M, Zimmermann H, Volknandt W
Journal of neurochemistry (2009) 1083: 662-75. 117 002 WB
WB
IHC-P
Background
Inositol 1, 4, 5 - trisphophate InsP3 is an intracellular messenger that triggers release of Ca2+ from intracellular stores. InsP3 acts by binding to specific receptors localized to endoplasmic reticulum.
There are at least three types of InsP3 receptors, of which the type 1 receptor is the most abundant. All three receptors appear to be widely expressed. Highest levels of the type 1 InsP3 receptors are found in neurons, with very high expression in the Purkinje cells of the cerebellum.
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