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Gephyrin antibody - 147 021 K.O.

Gephyrin is a scaffolding protein associated with inhibitory neurotransmitter receptors
Mouse monoclonal hybridoma supernatant
Cat. No.: 147 021
Amount: 300 µl
Price: $435.00
Cat. No. 147 021 300 µl hybridoma supernatant, lyophilized. For reconstitution add 300 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: not recommended (see remarks)
IP: not recommended (see remarks)
ICC: 1 : 250 up to 1 : 500 gallery  
IHC: 1 : 100 up to 1 : 250 (see remarks) gallery  
IHC-P: not recommended
ExM: yes
EM: yes
Clone mAb7a
Subtype IgG1 (κ light chain)
Immunogen Nativ Protein corresponding to AA 1 to 768 from rat Gephyrin (UniProt Id: Q03555)
Epitop AA 264 to 276 from rat Gephyrin (UniProt Id: Q03555)
Reactivity Reacts with: human (Q9NQX3), rat (Q03555), mouse (Q8BUV3), pig, goldfish, zebrafish, frog.
Other species not tested yet.
Specificity Specific for the brain specific 93 kDa splice variant phosphorylated at Ser-270. K.O. validated
Remarks

WB: Clone 3B11 (cat. no. 147 111) is highly recommended.
IP: Clone 3B11 (cat. no. 147 111) highly recommended.
IHC: Hybridoma supernatant highly recommended. For best results use the protocol of Schneider Gasser et al., 2006.
Alternatively antigen retrieval (10 mM citrate, pH 6.0, over night at 60°C) can be applied.

Glyoxal fixation according to Konno et al. 2023 has improved signal quality and strength.

Data sheet 147_021.pdf

References for Gephyrin - 147 021

Sleep and wake cycles dynamically modulate hippocampal inhibitory synaptic plasticity.
Wu K, Han W, Lu W
PLoS biology (2022) 2011: e3001812. 147 021 WB; tested species: mouse
Interference With Complex IV as a Model of Age-Related Decline in Synaptic Connectivity.
Kriebel M, Ebel J, Battke F, Griesbach S, Volkmer H
Frontiers in molecular neuroscience (2020) 13: 43. 147 021 WB, ICC; tested species: rat
Expression of Neurofilament Subunits at Neocortical Glutamatergic and GABAergic Synapses.
Bragina L, Conti F
Frontiers in neuroanatomy (2018) 12: 74. 147 021 WB, IHC; tested species: rat
Molecular Dissection of Neuroligin 2 and Slitrk3 Reveals an Essential Framework for GABAergic Synapse Development.
Li J, Han W, Pelkey KA, Duan J, Mao X, Wang YX, Craig MT, Dong L, Petralia RS, McBain CJ, Lu W, et al.
Neuron (2017) 964: 808-826.e8. 147 021 WB, ICC, IHC; tested species: mouse
Structural and functional reorganization of inhibitory synapses by activity-dependent cleavage of neuroligin-2.
Xu N, Cao R, Chen SY, Gou XZ, Wang B, Luo HM, Gao F, Tang AH
Proceedings of the National Academy of Sciences of the United States of America (2024) 12118: e2314541121. 147 021 ICC; tested species: mouse
Effects of psoralidin on the expression of glutamate decarboxylases and inhibitory synapse development.
Lee SE, Lee GH
Journal of Asian natural products research (2024) : 1-9. 147 021 ICC; tested species: mouse
Molecular definition of distinct active zone protein machineries for Ca2+ channel clustering and synaptic vesicle priming.
Emperador-Melero J, Andersen JW, Metzbower SR, Levy AD, Dharmasri PA, de Nola G, Blanpied TA, Kaeser PS
bioRxiv : the preprint server for biology (2023) : . 147 021 ICC; tested species: mouse
Super-resolution imaging of synaptic scaffold proteins in rat hippocampal neurons.
Guzikowski NJ, Kavalali ET
STAR protocols (2023) 41: 102080. 147 021 ICC; tested species: rat
Alternative splicing and heparan sulfation converge on neurexin-1 to control glutamatergic transmission and autism-related behaviors.
Lu H, Zuo L, Roddick KM, Zhang P, Oku S, Garden J, Ge Y, Bellefontaine M, Delhaye M, Brown RE, Craig AM, et al.
Cell reports (2023) 427: 112714. 147 021 ICC; tested species: rat
Aminoprocalcitonin protects against hippocampal neuronal death via preserving oxidative phosphorylation in refractory status epilepticus.
Song C, Zhao J, Hao J, Mi D, Zhang J, Liu Y, Wu S, Gao F, Jiang W
Cell death discovery (2023) 91: 144. 147 021 ICC; tested species: rat
Targeted proteoform mapping uncovers specific Neurexin-3 variants required for dendritic inhibition.
Hauser D, Behr K, Konno K, Schreiner D, Schmidt A, Watanabe M, Bischofberger J, Scheiffele P
Neuron (2022) 11013: 2094-2109.e10. 147 021 ICC; tested species: mouse
Nano-organization of spontaneous GABAergic transmission directs its autonomous function in neuronal signaling.
Guzikowski NJ, Kavalali ET
Cell reports (2022) 406: 111172. 147 021 ICC; tested species: rat
Trophic factor BDNF inhibits GABAergic signaling by facilitating dendritic enrichment of SUMO E3 ligase PIAS3 and altering gephyrin scaffold.
Thirouin ZS, Figueiredo M, Hleihil M, Gill R, Bosshard G, McKinney RA, Tyagarajan SK
The Journal of biological chemistry (2022) : 101840. 147 021 ICC; tested species: rat
Reelin Affects Signaling Pathways of a Group of Inhibitory Neurons and the Development of Inhibitory Synapses in Primary Neurons.
Lee SE, Lee GH
International journal of molecular sciences (2021) 2214: . 147 021 ICC; tested species: mouse
Autism Spectrum Disorder Risk Factor Met Regulates the Organization of Inhibitory Synapses.
Jeckel P, Kriebel M, Volkmer H
Frontiers in molecular neuroscience (2021) 14: 659856. 147 021 ICC; tested species: rat
Intact synapse structure and function after combined knockout of PTPδ, PTPσ, and LAR.
Emperador-Melero J, de Nola G, Kaeser PS
eLife (2021) 10: . 147 021 ICC; tested species: mouse
Role of Aberrant Spontaneous Neurotransmission in SNAP25-Associated Encephalopathies.
Alten B, Zhou Q, Shin OH, Esquivies L, Lin PY, White KI, Sun R, Chung WK, Monteggia LM, Brunger AT, Kavalali ET, et al.
Neuron (2020) : . 147 021 ICC; tested species: mouse
Interference With Complex IV as a Model of Age-Related Decline in Synaptic Connectivity.
Kriebel M, Ebel J, Battke F, Griesbach S, Volkmer H
Frontiers in molecular neuroscience (2020) 13: 43. 147 021 WB, ICC; tested species: rat
Phosphorylation on Ser 359 of the α2 subunit in GABA type A receptors down-regulates their density at inhibitory synapses.
Nakamura Y, Morrow DH, Nathanson AJ, Henley JM, Wilkinson KA, Moss SJ
The Journal of biological chemistry (2020) : . 147 021 ICC; tested species: rat
Presynaptic α2δ-2 Calcium Channel Subunits Regulate Postsynaptic GABAA Receptor Abundance and Axonal Wiring.
Geisler S, Schöpf CL, Stanika R, Kalb M, Campiglio M, Repetto D, Traxler L, Missler M, Obermair GJ
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) 3914: 2581-2605. 147 021 ICC; tested species: mouse
Sorting nexin 27 rescues neuroligin 2 from lysosomal degradation to control inhibitory synapse number.
Binda C, Nakamura Y, Henley J, Wilkinson K
The Biochemical journal (2019) : . 147 021 ICC; tested species: rat
Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and β1-integrin.
Fossati G, Pozzi D, Canzi A, Mirabella F, Valentino S, Morini R, Ghirardini E, Filipello F, Moretti M, Gotti C, Annis DS, et al.
The EMBO journal (2018) : . 147 021 ICC; tested species: mouse
The Role of Agrin, Lrp4 and MuSK during Dendritic Arborization and Synaptogenesis in Cultured Embryonic CNS Neurons.
Handara G, Hetsch FJA, Jüttner R, Schick A, Haupt C, Rathjen FG, Kröger S
Developmental biology (2018) : . 147 021 ICC; tested species: mouse
Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships.
Zhang P, Lu H, Peixoto RT, Pines MK, Ge Y, Oku S, Siddiqui TJ, Xie Y, Wu W, Archer-Hartmann S, Yoshida K, et al.
Cell (2018) : . 147 021 ICC; tested species: rat
Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons.
Ripamonti S, Ambrozkiewicz MC, Guzzi F, Gravati M, Biella G, Bormuth I, Hammer M, Tuffy LP, Sigler A, Kawabe H, Nishimori K, et al.
eLife (2017) 6: . 147 021 ICC; tested species: mouse
Nanoscale Structural Plasticity of the Active Zone Matrix Modulates Presynaptic Function.
Glebov OO, Jackson RE, Winterflood CM, Owen DM, Barker EA, Doherty P, Ewers H, Burrone J
Cell reports (2017) 1811: 2715-2728. 147 021 ICC
Molecular Dissection of Neuroligin 2 and Slitrk3 Reveals an Essential Framework for GABAergic Synapse Development.
Li J, Han W, Pelkey KA, Duan J, Mao X, Wang YX, Craig MT, Dong L, Petralia RS, McBain CJ, Lu W, et al.
Neuron (2017) 964: 808-826.e8. 147 021 WB, ICC, IHC; tested species: mouse
DISC1, astrocytes and neuronal maturation: a possible mechanistic link with implications for mental disorders.
Xia M, Zhu S, Shevelkin A, Ross CA, Pletnikov M
Journal of neurochemistry (2016) 1384: 518-24. 147 021 ICC; tested species: mouse
Proteomic Characterization of Inhibitory Synapses Using a Novel pHluorin-tagged γ-Aminobutyric Acid Receptor, Type A (GABAA), α2 Subunit Knock-in Mouse.
Nakamura Y, Morrow DH, Modgil A, Huyghe D, Deeb TZ, Lumb MJ, Davies PA, Moss SJ
The Journal of biological chemistry (2016) 29123: 12394-407. 147 021 ICC
Identification and characterization of GABA(A) receptor autoantibodies in autoimmune encephalitis.
Ohkawa T, Satake S, Yokoi N, Miyazaki Y, Ohshita T, Sobue G, Takashima H, Watanabe O, Fukata Y, Fukata M
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3424: 8151-63. 147 021 ICC; tested species: rat
Electron tomography on γ-aminobutyric acid-ergic synapses reveals a discontinuous postsynaptic network of filaments.
Linsalata AE, Chen X, Winters CA, Reese TS
The Journal of comparative neurology (2014) 5224: 921-36. 147 021 EM, ICC; tested species: rat
Molecular and functional interaction between protocadherin-γC5 and GABAA receptors.
Li Y, Xiao H, Chiou TT, Jin H, Bonhomme B, Miralles CP, Pinal N, Ali R, Chen WV, Maniatis T, De Blas AL, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 3234: 11780-97. 147 021 ICC
A readily retrievable pool of synaptic vesicles.
Hua Y, Sinha R, Thiel CS, Schmidt R, Hüve J, Martens H, Hell SW, Egner A, Klingauf J
Nature neuroscience (2011) 147: 833-9. 147 021 ICC
Synaptic communication within the microcircuits of pyramidal neurons and basket cells in the mouse prefrontal cortex.
Fekete Z, Weisz F, Karlócai MR, Veres JM, Andrási T, Hájos N
The Journal of physiology (2024) : . 147 021 IHC; tested species: mouse
A zebrafish gephyrinb mutant distinguishes synaptic and enzymatic functions of Gephyrin.
Brennan EJ, Monk KR, Li J
Neural development (2024) 191: 14. 147 021 IHC; tested species: zebrafish
Multimodal sensory control of motor performance by glycinergic interneurons of the mouse spinal cord deep dorsal horn.
Gradwell MA, Ozeri-Engelhard N, Eisdorfer JT, Laflamme OD, Gonzalez M, Upadhyay A, Medlock L, Shrier T, Patel KR, Aoki A, Gandhi M, et al.
Neuron (2024) 1128: 1302-1327.e13. 147 021 IHC; tested species: mouse
Synaptic and dendritic architecture of different types of hippocampal somatostatin interneurons.
Takács V, Bardóczi Z, Orosz Á, Major A, Tar L, Berki P, Papp P, Mayer MI, Sebők H, Zsolt L, Sos KE, et al.
PLoS biology (2024) 223: e3002539. 147 021 IHC; tested species: mouse
iPSC-derived models of PACS1 syndrome reveal transcriptional and functional deficits in neuron activity.
Rylaarsdam L, Rakotomamonjy J, Pope E, Guemez-Gamboa A
Nature communications (2024) 151: 827. 147 021 IHC; tested species: human
Cerebrospinal fluid-contacting neuron tracing reveals structural and functional connectivity for locomotion in the mouse spinal cord.
Nakamura Y, Kurabe M, Matsumoto M, Sato T, Miyashita S, Hoshina K, Kamiya Y, Tainaka K, Matsuzawa H, Ohno N, Ueno M, et al.
eLife (2023) 12: . 147 021 IHC; tested species: mouse
Time-dependent and selective microglia-mediated removal of spinal synapses in neuropathic pain.
Yousefpour N, Locke S, Deamond H, Wang C, Marques L, St-Louis M, Ouellette J, Khoutorsky A, De Koninck Y, Ribeiro-da-Silva A
Cell reports (2023) 421: 112010. 147 021 IHC; tested species: mouse
Neonatal loss of FGFR2 in astroglial cells affects locomotion, sociability, working memory, and glia-neuron interactions in mice.
Stevens HE, Scuderi S, Collica SC, Tomasi S, Horvath TL, Vaccarino FM
Translational psychiatry (2023) 131: 89. 147 021 IHC; tested species: mouse
Acan downregulation in parvalbumin GABAergic cells reduces spontaneous recovery of fear memories.
Lavertu-Jolin M, Chattopadhyaya B, Chehrazi P, Carrier D, Wünnemann F, Leclerc S, Dumouchel F, Robertson D, Affia H, Saba K, Gopal V, et al.
Molecular psychiatry (2023) : . 147 021 IHC; tested species: mouse
Botulinum neurotoxin A ameliorates depressive-like behavior in a reserpine-induced Parkinson's disease mouse model via suppressing hippocampal microglial engulfment and neuroinflammation.
Li Y, Yin Q, Li Q, Huo AR, Shen TT, Cao JQ, Liu CF, Liu T, Luo WF, Cong QF
Acta pharmacologica Sinica (2023) 447: 1322-1336. 147 021 IHC; tested species: mouse
The p75 Neurotrophin Receptor in Preadolescent Prefrontal Parvalbumin Interneurons Promotes Cognitive Flexibility in Adult Mice.
Chehrazi P, Lee KKY, Lavertu-Jolin M, Abbasnejad Z, Carreño-Muñoz MI, Chattopadhyaya B, Di Cristo G
Biological psychiatry (2023) 944: 310-321. 147 021 IHC; tested species: mouse
Prenatal methadone exposure selectively alters protein expression in primary motor cortex: Implications for synaptic function.
Haggerty DL, Grecco GG, Huang JY, Doud EH, Mosley AL, Lu HC, Atwood BK
Frontiers in pharmacology (2023) 14: 1124108. 147 021 IHC; tested species: mouse
Neuronal P2X4 receptor may contribute to peripheral inflammatory pain in rat spinal dorsal horn.
Ducza L, Gajtkó A, Hegedűs K, Bakk E, Kis G, Gaál B, Takács R, Szücs P, Matesz K, Holló K
Frontiers in molecular neuroscience (2023) 16: 1115685. 147 021 IHC; tested species: rat
Glyoxal fixation: An approach to solve immunohistochemical problem in neuroscience research.
Konno K, Yamasaki M, Miyazaki T, Watanabe M
Science advances (2023) 928: eadf7084. 147 021 IHC; tested species: mouse
An inhibitory circuit-based enhancer of DYRK1A function reverses Dyrk1a-associated impairment in social recognition.
Shih YT, Alipio JB, Sahay A
Neuron (2023) 11119: 3084-3101.e5. 147 021 IHC; tested species: mouse
Synaptic mechanisms for associative learning in the cerebellar nuclei.
Broersen R, Albergaria C, Carulli D, Carey MR, Canto CB, De Zeeuw CI
Nature communications (2023) 141: 7459. 147 021 IHC; tested species: mouse
Heterogeneous complement and microglia activation mediates stress-induced synapse loss.
Soteros BM, Tillmon H, Wollet M, General J, Chin H, Lee JB, Carreno FR, Morilak DA, Kim JH, Sia GM
bioRxiv : the preprint server for biology (2023) : . 147 021 IHC; tested species: mouse
Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signalling.
Boyle KA, Polgar E, Gutierrez-Mecinas M, Dickie AC, Cooper AH, Bell AM, Jumolea E, Casas-Benito A, Watanabe M, Hughes DI, Weir GA, et al.
eLife (2023) 12: . 147 021 IHC; tested species: mouse
Rejection of inappropriate synaptic partners in mouse retina mediated by transcellular FLRT2-UNC5 signaling.
Prigge CL, Dembla M, Sharma A, El-Quessny M, Kozlowski C, Paisley CE, Miltner AM, Johnson TM, Della Santina L, Feller MB, Kay JN, et al.
Developmental cell (2023) 5820: 2080-2096.e7. 147 021 IHC; tested species: mouse
Neuronal Activity Changes the Number of Neurons that are Synaptically Connected to OPCs.
Moura D, Parvathaneni A, Sahagun A, Noguchi H, Garcia J, Brennan E, Brock R, Tilton I, Halladay L, Pleasure S, Cocas L, et al.
eNeuro (2023) : . 147 021 IHC; tested species: mouse
Chronic partial TrkB activation reduces seizures and mortality in a mouse model of Dravet syndrome.
Gu F, Parada I, Yang T, Longo FM, Prince DA
Proceedings of the National Academy of Sciences of the United States of America (2022) 1197: . 147 021 IHC; tested species: mouse
Loss of KCC2 in GABAergic Neurons Causes Seizures and an Imbalance of Cortical Interneurons.
Zavalin K, Hassan A, Fu C, Delpire E, Lagrange AH
Frontiers in molecular neuroscience (2022) 15: 826427. 147 021 IHC; tested species: mouse
Different priming states of synaptic vesicles underlie distinct release probabilities at hippocampal excitatory synapses.
Aldahabi M, Balint F, Holderith N, Lorincz A, Reva M, Nusser Z
Neuron (2022) : . 147 021 IHC; tested species: mouse
Prepubescent female rodents have enhanced hippocampal LTP and learning relative to males, reversing in adulthood as inhibition increases.
Le AA, Lauterborn JC, Jia Y, Wang W, Cox CD, Gall CM, Lynch G
Nature neuroscience (2022) 252: 180-190. 147 021 IHC; tested species: rat
Identification of intraneuronal amyloid beta oligomers in locus coeruleus neurons of Alzheimer's patients and their potential impact on inhibitory neurotransmitter receptors and neuronal excitability.
Kelly L, Seifi M, Ma R, Mitchell SJ, Rudolph U, Viola KL, Klein WL, Lambert JJ, Swinny JD
Neuropathology and applied neurobiology (2021) 474: 488-505. 147 021 IHC; tested species: mouse
Total Number and Ratio of GABAergic Neuron Types in the Mouse Lateral and Basal Amygdala.
Vereczki VK, Müller K, Krizsán É, Máté Z, Fekete Z, Rovira-Esteban L, Veres JM, Erdélyi F, Hájos N
The Journal of neuroscience : the official journal of the Society for Neuroscience (2021) 4121: 4575-4595. 147 021 IHC; tested species: mouse
Identification of neural oscillations and epileptiform changes in human brain organoids.
Samarasinghe RA, Miranda OA, Buth JE, Mitchell S, Ferando I, Watanabe M, Allison TF, Kurdian A, Fotion NN, Gandal MJ, Golshani P, et al.
Nature neuroscience (2021) 2410: 1488-1500. 147 021 IHC; tested species: human
PUPIL enables mapping and stamping of transient electrical connectivity in developing nervous systems.
Xie S, Li H, Yao F, Huang J, Yang X, Chen X, Liu Q, Zhuang M, He S
Cell reports (2021) 373: 109853. 147 021 IHC; tested species: mouse
Sex-dependent long-term effects of prepubescent stress on the posterior parietal cortex.
Fariborzi M, Park SB, Ozgur A, Lur G
Neurobiology of stress (2021) 14: 100295. 147 021 IHC; tested species: mouse
Sensitive period for rescuing parvalbumin interneurons connectivity and social behavior deficits caused by TSC1 loss.
Amegandjin CA, Choudhury M, Jadhav V, Carriço JN, Quintal A, Berryer M, Snapyan M, Chattopadhyaya B, Saghatelyan A, Di Cristo G
Nature communications (2021) 121: 3653. 147 021 IHC; tested species: mouse
Tonic GABAergic inhibition, via GABAA receptors containing αβƐ subunits, regulates excitability of ventral tegmental area dopamine neurons.
Tossell K, Dodhia RA, Galet B, Tkachuk O, Ungless MA
The European journal of neuroscience (2021) : . 147 021 IHC; tested species: mouse
Dopamine depletion induces neuron-specific alterations of GABAergic transmission in the mouse striatum.
Boccalaro IL, Schwerdel C, Cristiá-Lara L, Fritschy JM, Rubi L
The European journal of neuroscience (2020) 525: 3353-3374. 147 021 IHC; tested species: mouse
Microglia monitor and protect neuronal function through specialized somatic purinergic junctions.
Cserép C, Pósfai B, Lénárt N, Fekete R, László ZI, Lele Z, Orsolits B, Molnár G, Heindl S, Schwarcz AD, Ujvári K, et al.
Science (New York, N.Y.) (2020) 3676477: 528-537. 147 021 IHC; tested species: mouse
Phrenic-specific transcriptional programs shape respiratory motor output.
Vagnozzi AN, Garg K, Dewitz C, Moore MT, Cregg JM, Jeannotte L, Zampieri N, Landmesser LT, Philippidou P
eLife (2020) 9: . 147 021 IHC; tested species: mouse
Spinal Wnt5a Plays a Key Role in Spinal Dendritic Spine Remodeling in Neuropathic and Inflammatory Pain Models and in the Proalgesic Effects of Peripheral Wnt3a.
Simonetti M, Kuner R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) 4035: 6664-6677. 147 021 IHC; tested species: mouse
The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development.
Cong Q, Soteros BM, Wollet M, Kim JH, Sia GM
Nature neuroscience (2020) : . 147 021 IHC; tested species: mouse
Developmental Regulation of Basket Interneuron Synapses and Behavior through NCAM in Mouse Prefrontal Cortex.
Sullivan CS, Mohan V, Manis PB, Moy SS, Truong Y, Duncan BW, Maness PF
Cerebral cortex (New York, N.Y. : 1991) (2020) : . 147 021 IHC; tested species: mouse
A High-Resolution Method for Quantitative Molecular Analysis of Functionally Characterized Individual Synapses.
Holderith N, Heredi J, Kis V, Nusser Z
Cell reports (2020) 324: 107968. 147 021 IHC; tested species: rat
Expression of protocadherin-γC4 protein in the rat brain.
Miralles CP, Taylor MJ, Bear J, Fekete CD, George S, Li Y, Bonhomme B, Chiou TT, De Blas AL
The Journal of comparative neurology (2019) : . 147 021 IHC; tested species: rat
Expression mapping, quantification, and complex formation of GluD1 and GluD2 glutamate receptors in adult mouse brain.
Nakamoto C, Konno K, Miyazaki T, Nakatsukasa E, Natsume R, Abe M, Kawamura M, Fukazawa Y, Shigemto R, Yamasaki M, Sakimura K, et al.
The Journal of comparative neurology (2019) : . 147 021 IHC; tested species: mouse
Cell type-specific distribution of GABAA receptor subtypes in the mouse dorsal striatum.
Boccalaro IL, Cristiá-Lara L, Schwerdel C, Fritschy JM, Rubi L
The Journal of comparative neurology (2019) : . 147 021 IHC; tested species: mouse
Development of inhibitory synaptic inputs on layer 2/3 pyramidal neurons in the rat medial prefrontal cortex.
Virtanen MA, Lacoh CM, Fiumelli H, Kosel M, Tyagarajan S, de Roo M, Vutskits L
Brain structure & function (2018) 2234: 1999-2012. 147 021 IHC; tested species: rat
Excitatory synaptic dysfunction cell-autonomously decreases inhibitory inputs and disrupts structural and functional plasticity.
He HY, Shen W, Zheng L, Guo X, Cline HT
Nature communications (2018) 91: 2893. 147 021 IHC; tested species: frog
Extrasynaptic homomeric glycine receptors in neurons of the rat trigeminal mesencephalic nucleus.
Bae JY, Lee JS, Ko SJ, Cho YS, Rah JC, Cho HJ, Park MJ, Bae YC
Brain structure & function (2018) : . 147 021 IHC, EM; tested species: rat
Subretinal Human Umbilical Tissue-Derived Cell Transplantation Preserves Retinal Synaptic Connectivity and Attenuates Müller Glial Reactivity.
Koh S, Chen WJ, Dejneka NS, Harris IR, Lu B, Girman S, Saylor J, Wang S, Eroglu C
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3812: 2923-2943. 147 021 IHC; tested species: rat
GABAergic malfunction in the anterior cingulate cortex underlying maternal immune activation-induced social deficits.
Okamoto K, Hitora-Imamura N, Hioki H, Ikegaya Y
Journal of neuroimmunology (2018) 321: 92-96. 147 021 IHC; tested species: mouse
Dynamic Modulation of Mouse Locus Coeruleus Neurons by Vasopressin 1a and 1b Receptors.
Campos-Lira E, Kelly L, Seifi M, Jackson T, Giesecke T, Mutig K, Koshimizu TA, Hernandez VS, Zhang L, Swinny JD
Frontiers in neuroscience (2018) 12: 919. 147 021 IHC; tested species: mouse
Glycine receptors expression in rat spinal cord and dorsal root ganglion in prostaglandin E2 intrathecal injection models.
Wang HC, Cheng KI, Chen PR, Tseng KY, Kwan AL, Chang LL
BMC neuroscience (2018) 191: 72. 147 021 IHC; tested species: rat
Expression of Neurofilament Subunits at Neocortical Glutamatergic and GABAergic Synapses.
Bragina L, Conti F
Frontiers in neuroanatomy (2018) 12: 74. 147 021 WB, IHC; tested species: rat
In vivo transgenic expression of collybistin in neurons of the rat cerebral cortex.
Fekete CD, Goz RU, Dinallo S, Miralles CP, Chiou TT, Bear J, Fiondella CG, LoTurco JJ, De Blas AL
The Journal of comparative neurology (2017) 5255: 1291-1311. 147 021 IHC; tested species: rat
The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn.
Abraira VE, Kuehn ED, Chirila AM, Springel MW, Toliver AA, Zimmerman AL, Orefice LL, Boyle KA, Bai L, Song BJ, Bashista KA, et al.
Cell (2017) 1681-2: 295-310.e19. 147 021 IHC; tested species: mouse
Molecular Dissection of Neuroligin 2 and Slitrk3 Reveals an Essential Framework for GABAergic Synapse Development.
Li J, Han W, Pelkey KA, Duan J, Mao X, Wang YX, Craig MT, Dong L, Petralia RS, McBain CJ, Lu W, et al.
Neuron (2017) 964: 808-826.e8. 147 021 WB, ICC, IHC; tested species: mouse
Early postnatal GABAA receptor modulation reverses deficits in neuronal maturation in a conditional neurodevelopmental mouse model of DISC1.
Saito A, Taniguchi Y, Rannals MD, Merfeld EB, Ballinger MD, Koga M, Ohtani Y, Gurley DA, Sedlak TW, Cross A, Moss SJ, et al.
Molecular psychiatry (2016) 2110: 1449-59. 147 021 IHC
Neuronal Dystroglycan Is Necessary for Formation and Maintenance of Functional CCK-Positive Basket Cell Terminals on Pyramidal Cells.
Früh S, Romanos J, Panzanelli P, Bürgisser D, Tyagarajan SK, Campbell KP, Santello M, Fritschy JM
The Journal of neuroscience : the official journal of the Society for Neuroscience (2016) 3640: 10296-10313. 147 021 IHC; tested species: mouse
Repetitive magnetic stimulation induces plasticity of inhibitory synapses.
Lenz M, Galanis C, Müller-Dahlhaus F, Opitz A, Wierenga CJ, Szabó G, Ziemann U, Deller T, Funke K, Vlachos A
Nature communications (2016) 7: 10020. 147 021 IHC
Forebrain-specific loss of synaptic GABAA receptors results in altered neuronal excitability and synaptic plasticity in mice.
O'Sullivan GA, Jedlicka P, Chen HX, Kalbouneh H, Ippolito A, Deller T, Nawrotzki RA, Kuhse J, Kalaidzidis YL, Kirsch J, Schwarzacher SW, et al.
Molecular and cellular neurosciences (2016) 72: 101-13. 147 021 IHC
Immunostaining for Homer reveals the majority of excitatory synapses in laminae I-III of the mouse spinal dorsal horn.
Gutierrez-Mecinas M, Kuehn ED, Abraira VE, Polgár E, Watanabe M, Todd AJ
Neuroscience (2016) 329: 171-81. 147 021 IHC
In vivo clonal overexpression of neuroligin 3 and neuroligin 2 in neurons of the rat cerebral cortex: Differential effects on GABAergic synapses and neuronal migration.
Fekete CD, Chiou TT, Miralles CP, Harris RS, Fiondella CG, Loturco JJ, De Blas AL
The Journal of comparative neurology (2015) 5239: 1359-78. 147 021 IHC
KCNQ5 K(+) channels control hippocampal synaptic inhibition and fast network oscillations.
Fidzinski P, Korotkova T, Heidenreich M, Maier N, Schuetze S, Kobler O, Zuschratter W, Schmitz D, Ponomarenko A, Jentsch TJ
Nature communications (2015) 6: 6254. 147 021 IHC
Activity-dependent inhibitory synapse remodeling through gephyrin phosphorylation.
Flores CE, Nikonenko I, Mendez P, Fritschy JM, Tyagarajan SK, Muller D
Proceedings of the National Academy of Sciences of the United States of America (2015) 1121: E65-72. 147 021 IHC
Bassoon-disruption slows vesicle replenishment and induces homeostatic plasticity at a CNS synapse.
Mendoza Schulz A, Jing Z, Sánchez Caro JM, Wetzel F, Dresbach T, Strenzke N, Wichmann C, Moser T
The EMBO journal (2014) 335: 512-27. 147 021 IHC
Synaptic recruitment of gephyrin regulates surface GABAA receptor dynamics for the expression of inhibitory LTP.
Petrini EM, Ravasenga T, Hausrat TJ, Iurilli G, Olcese U, Racine V, Sibarita JB, Jacob TC, Moss SJ, Benfenati F, Medini P, et al.
Nature communications (2014) 5: 3921. 147 021 IHC; tested species: mouse
A protocol for concurrent high-quality immunohistochemical and biochemical analyses in adult mouse central nervous system.
Notter T, Panzanelli P, Pfister S, Mircsof D, Fritschy JM
The European journal of neuroscience (2014) 392: 165-75. 147 021 IHC, EM
Brain inflammation induces post-synaptic changes during early synapse formation in adult-born hippocampal neurons.
Chugh D, Nilsson P, Afjei SA, Bakochi A, Ekdahl CT
Experimental neurology (2013) 250: 176-88. 147 021 IHC; tested species: mouse
A dramatic increase of C1q protein in the CNS during normal aging.
Stephan AH, Madison DV, Mateos JM, Fraser DA, Lovelett EA, Coutellier L, Kim L, Tsai HH, Huang EJ, Rowitch DH, Berns DS, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3333: 13460-74. 147 021 IHC; tested species: mouse
Reducing GABAA α5 receptor-mediated inhibition rescues functional and neuromorphological deficits in a mouse model of down syndrome.
Martínez-Cué C, Martínez P, Rueda N, Vidal R, García S, Vidal V, Corrales A, Montero JA, Pazos Á, Flórez J, Gasser R, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 339: 3953-66. 147 021 IHC; tested species: mouse
Amacrine and bipolar inputs to midget and parasol ganglion cells in marmoset retina.
Abbott CJ, Percival KA, Martin PR, Grünert U
Visual neuroscience (2012) 293: 157-68. 147 021 IHC; tested species: marmoset
Altered synaptic properties during integration of adult-born hippocampal neurons following a seizure insult.
Jackson J, Chugh D, Nilsson P, Wood J, Carlström K, Lindvall O, Ekdahl CT
PloS one (2012) 74: e35557. 147 021 IHC
Postsynaptic TrkC and presynaptic PTPσ function as a bidirectional excitatory synaptic organizing complex.
Takahashi H, Arstikaitis P, Prasad T, Bartlett TE, Wang YT, Murphy TH, Craig AM
Neuron (2011) 692: 287-303. 147 021 IHC; tested species: mouse,rat
Age-related changes of glycine receptor at the rat hippocampus: from the embryo to the adult.
Aroeira RI, Ribeiro JA, Sebastião AM, Valente CA
Journal of neurochemistry (2011) 1183: 339-53. 147 021 IHC; tested species: rat
Hyperexcitability, interneurons, and loss of GABAergic synapses in entorhinal cortex in a model of temporal lobe epilepsy.
Kumar SS, Buckmaster PS
The Journal of neuroscience : the official journal of the Society for Neuroscience (2006) 2617: 4613-23. 147 021 IHC; tested species: rat
Structural Heterogeneity of the GABAergic Tripartite Synapse.
Brunskine C, Passlick S, Henneberger C
Cells (2022) 1119: . 147 021 ExM; tested species: mouse
Spatial proteomics in neurons at single-protein resolution.
Unterauer EM, Shetab Boushehri S, Jevdokimenko K, Masullo LA, Ganji M, Sograte-Idrissi S, Kowalewski R, Strauss S, Reinhardt SCM, Perovic A, Marr C, et al.
Cell (2024) 1877: 1785-1800.e16. 147 021 DNA-PAINT; tested species: rat
High-resolution Immunoelectron Microscopy Techniques for Revealing Distinct Subcellular Type 1 Cannabinoid Receptor Domains in Brain.
Puente N, Río IB, Achicallende S, Nahirney PC, Grandes P
Bio-protocol (2019) 92: e3145. 147 021 EM; tested species: mouse
Extrasynaptic homomeric glycine receptors in neurons of the rat trigeminal mesencephalic nucleus.
Bae JY, Lee JS, Ko SJ, Cho YS, Rah JC, Cho HJ, Park MJ, Bae YC
Brain structure & function (2018) : . 147 021 IHC, EM; tested species: rat
A protocol for concurrent high-quality immunohistochemical and biochemical analyses in adult mouse central nervous system.
Notter T, Panzanelli P, Pfister S, Mircsof D, Fritschy JM
The European journal of neuroscience (2014) 392: 165-75. 147 021 IHC, EM
Electron tomography on γ-aminobutyric acid-ergic synapses reveals a discontinuous postsynaptic network of filaments.
Linsalata AE, Chen X, Winters CA, Reese TS
The Journal of comparative neurology (2014) 5224: 921-36. 147 021 EM, ICC; tested species: rat
Cat. No.: 147 021
Amount: 300 µl
Price: $435.00
Sleep and wake cycles dynamically modulate hippocampal inhibitory synaptic plasticity.
Wu K, Han W, Lu W
PLoS biology (2022) 2011: e3001812. 147 021 WB; tested species: mouse
Interference With Complex IV as a Model of Age-Related Decline in Synaptic Connectivity.
Kriebel M, Ebel J, Battke F, Griesbach S, Volkmer H
Frontiers in molecular neuroscience (2020) 13: 43. 147 021 WB, ICC; tested species: rat
Expression of Neurofilament Subunits at Neocortical Glutamatergic and GABAergic Synapses.
Bragina L, Conti F
Frontiers in neuroanatomy (2018) 12: 74. 147 021 WB, IHC; tested species: rat
Molecular Dissection of Neuroligin 2 and Slitrk3 Reveals an Essential Framework for GABAergic Synapse Development.
Li J, Han W, Pelkey KA, Duan J, Mao X, Wang YX, Craig MT, Dong L, Petralia RS, McBain CJ, Lu W, et al.
Neuron (2017) 964: 808-826.e8. 147 021 WB, ICC, IHC; tested species: mouse
Structural and functional reorganization of inhibitory synapses by activity-dependent cleavage of neuroligin-2.
Xu N, Cao R, Chen SY, Gou XZ, Wang B, Luo HM, Gao F, Tang AH
Proceedings of the National Academy of Sciences of the United States of America (2024) 12118: e2314541121. 147 021 ICC; tested species: mouse
Effects of psoralidin on the expression of glutamate decarboxylases and inhibitory synapse development.
Lee SE, Lee GH
Journal of Asian natural products research (2024) : 1-9. 147 021 ICC; tested species: mouse
Molecular definition of distinct active zone protein machineries for Ca2+ channel clustering and synaptic vesicle priming.
Emperador-Melero J, Andersen JW, Metzbower SR, Levy AD, Dharmasri PA, de Nola G, Blanpied TA, Kaeser PS
bioRxiv : the preprint server for biology (2023) : . 147 021 ICC; tested species: mouse
Super-resolution imaging of synaptic scaffold proteins in rat hippocampal neurons.
Guzikowski NJ, Kavalali ET
STAR protocols (2023) 41: 102080. 147 021 ICC; tested species: rat
Alternative splicing and heparan sulfation converge on neurexin-1 to control glutamatergic transmission and autism-related behaviors.
Lu H, Zuo L, Roddick KM, Zhang P, Oku S, Garden J, Ge Y, Bellefontaine M, Delhaye M, Brown RE, Craig AM, et al.
Cell reports (2023) 427: 112714. 147 021 ICC; tested species: rat
Aminoprocalcitonin protects against hippocampal neuronal death via preserving oxidative phosphorylation in refractory status epilepticus.
Song C, Zhao J, Hao J, Mi D, Zhang J, Liu Y, Wu S, Gao F, Jiang W
Cell death discovery (2023) 91: 144. 147 021 ICC; tested species: rat
Targeted proteoform mapping uncovers specific Neurexin-3 variants required for dendritic inhibition.
Hauser D, Behr K, Konno K, Schreiner D, Schmidt A, Watanabe M, Bischofberger J, Scheiffele P
Neuron (2022) 11013: 2094-2109.e10. 147 021 ICC; tested species: mouse
Nano-organization of spontaneous GABAergic transmission directs its autonomous function in neuronal signaling.
Guzikowski NJ, Kavalali ET
Cell reports (2022) 406: 111172. 147 021 ICC; tested species: rat
Trophic factor BDNF inhibits GABAergic signaling by facilitating dendritic enrichment of SUMO E3 ligase PIAS3 and altering gephyrin scaffold.
Thirouin ZS, Figueiredo M, Hleihil M, Gill R, Bosshard G, McKinney RA, Tyagarajan SK
The Journal of biological chemistry (2022) : 101840. 147 021 ICC; tested species: rat
Reelin Affects Signaling Pathways of a Group of Inhibitory Neurons and the Development of Inhibitory Synapses in Primary Neurons.
Lee SE, Lee GH
International journal of molecular sciences (2021) 2214: . 147 021 ICC; tested species: mouse
Autism Spectrum Disorder Risk Factor Met Regulates the Organization of Inhibitory Synapses.
Jeckel P, Kriebel M, Volkmer H
Frontiers in molecular neuroscience (2021) 14: 659856. 147 021 ICC; tested species: rat
Intact synapse structure and function after combined knockout of PTPδ, PTPσ, and LAR.
Emperador-Melero J, de Nola G, Kaeser PS
eLife (2021) 10: . 147 021 ICC; tested species: mouse
Role of Aberrant Spontaneous Neurotransmission in SNAP25-Associated Encephalopathies.
Alten B, Zhou Q, Shin OH, Esquivies L, Lin PY, White KI, Sun R, Chung WK, Monteggia LM, Brunger AT, Kavalali ET, et al.
Neuron (2020) : . 147 021 ICC; tested species: mouse
Interference With Complex IV as a Model of Age-Related Decline in Synaptic Connectivity.
Kriebel M, Ebel J, Battke F, Griesbach S, Volkmer H
Frontiers in molecular neuroscience (2020) 13: 43. 147 021 WB, ICC; tested species: rat
Phosphorylation on Ser 359 of the α2 subunit in GABA type A receptors down-regulates their density at inhibitory synapses.
Nakamura Y, Morrow DH, Nathanson AJ, Henley JM, Wilkinson KA, Moss SJ
The Journal of biological chemistry (2020) : . 147 021 ICC; tested species: rat
Presynaptic α2δ-2 Calcium Channel Subunits Regulate Postsynaptic GABAA Receptor Abundance and Axonal Wiring.
Geisler S, Schöpf CL, Stanika R, Kalb M, Campiglio M, Repetto D, Traxler L, Missler M, Obermair GJ
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) 3914: 2581-2605. 147 021 ICC; tested species: mouse
Sorting nexin 27 rescues neuroligin 2 from lysosomal degradation to control inhibitory synapse number.
Binda C, Nakamura Y, Henley J, Wilkinson K
The Biochemical journal (2019) : . 147 021 ICC; tested species: rat
Pentraxin 3 regulates synaptic function by inducing AMPA receptor clustering via ECM remodeling and β1-integrin.
Fossati G, Pozzi D, Canzi A, Mirabella F, Valentino S, Morini R, Ghirardini E, Filipello F, Moretti M, Gotti C, Annis DS, et al.
The EMBO journal (2018) : . 147 021 ICC; tested species: mouse
The Role of Agrin, Lrp4 and MuSK during Dendritic Arborization and Synaptogenesis in Cultured Embryonic CNS Neurons.
Handara G, Hetsch FJA, Jüttner R, Schick A, Haupt C, Rathjen FG, Kröger S
Developmental biology (2018) : . 147 021 ICC; tested species: mouse
Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships.
Zhang P, Lu H, Peixoto RT, Pines MK, Ge Y, Oku S, Siddiqui TJ, Xie Y, Wu W, Archer-Hartmann S, Yoshida K, et al.
Cell (2018) : . 147 021 ICC; tested species: rat
Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons.
Ripamonti S, Ambrozkiewicz MC, Guzzi F, Gravati M, Biella G, Bormuth I, Hammer M, Tuffy LP, Sigler A, Kawabe H, Nishimori K, et al.
eLife (2017) 6: . 147 021 ICC; tested species: mouse
Nanoscale Structural Plasticity of the Active Zone Matrix Modulates Presynaptic Function.
Glebov OO, Jackson RE, Winterflood CM, Owen DM, Barker EA, Doherty P, Ewers H, Burrone J
Cell reports (2017) 1811: 2715-2728. 147 021 ICC
Molecular Dissection of Neuroligin 2 and Slitrk3 Reveals an Essential Framework for GABAergic Synapse Development.
Li J, Han W, Pelkey KA, Duan J, Mao X, Wang YX, Craig MT, Dong L, Petralia RS, McBain CJ, Lu W, et al.
Neuron (2017) 964: 808-826.e8. 147 021 WB, ICC, IHC; tested species: mouse
DISC1, astrocytes and neuronal maturation: a possible mechanistic link with implications for mental disorders.
Xia M, Zhu S, Shevelkin A, Ross CA, Pletnikov M
Journal of neurochemistry (2016) 1384: 518-24. 147 021 ICC; tested species: mouse
Proteomic Characterization of Inhibitory Synapses Using a Novel pHluorin-tagged γ-Aminobutyric Acid Receptor, Type A (GABAA), α2 Subunit Knock-in Mouse.
Nakamura Y, Morrow DH, Modgil A, Huyghe D, Deeb TZ, Lumb MJ, Davies PA, Moss SJ
The Journal of biological chemistry (2016) 29123: 12394-407. 147 021 ICC
Identification and characterization of GABA(A) receptor autoantibodies in autoimmune encephalitis.
Ohkawa T, Satake S, Yokoi N, Miyazaki Y, Ohshita T, Sobue G, Takashima H, Watanabe O, Fukata Y, Fukata M
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3424: 8151-63. 147 021 ICC; tested species: rat
Electron tomography on γ-aminobutyric acid-ergic synapses reveals a discontinuous postsynaptic network of filaments.
Linsalata AE, Chen X, Winters CA, Reese TS
The Journal of comparative neurology (2014) 5224: 921-36. 147 021 EM, ICC; tested species: rat
Molecular and functional interaction between protocadherin-γC5 and GABAA receptors.
Li Y, Xiao H, Chiou TT, Jin H, Bonhomme B, Miralles CP, Pinal N, Ali R, Chen WV, Maniatis T, De Blas AL, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 3234: 11780-97. 147 021 ICC
A readily retrievable pool of synaptic vesicles.
Hua Y, Sinha R, Thiel CS, Schmidt R, Hüve J, Martens H, Hell SW, Egner A, Klingauf J
Nature neuroscience (2011) 147: 833-9. 147 021 ICC
Synaptic communication within the microcircuits of pyramidal neurons and basket cells in the mouse prefrontal cortex.
Fekete Z, Weisz F, Karlócai MR, Veres JM, Andrási T, Hájos N
The Journal of physiology (2024) : . 147 021 IHC; tested species: mouse
A zebrafish gephyrinb mutant distinguishes synaptic and enzymatic functions of Gephyrin.
Brennan EJ, Monk KR, Li J
Neural development (2024) 191: 14. 147 021 IHC; tested species: zebrafish
Multimodal sensory control of motor performance by glycinergic interneurons of the mouse spinal cord deep dorsal horn.
Gradwell MA, Ozeri-Engelhard N, Eisdorfer JT, Laflamme OD, Gonzalez M, Upadhyay A, Medlock L, Shrier T, Patel KR, Aoki A, Gandhi M, et al.
Neuron (2024) 1128: 1302-1327.e13. 147 021 IHC; tested species: mouse
Synaptic and dendritic architecture of different types of hippocampal somatostatin interneurons.
Takács V, Bardóczi Z, Orosz Á, Major A, Tar L, Berki P, Papp P, Mayer MI, Sebők H, Zsolt L, Sos KE, et al.
PLoS biology (2024) 223: e3002539. 147 021 IHC; tested species: mouse
iPSC-derived models of PACS1 syndrome reveal transcriptional and functional deficits in neuron activity.
Rylaarsdam L, Rakotomamonjy J, Pope E, Guemez-Gamboa A
Nature communications (2024) 151: 827. 147 021 IHC; tested species: human
Cerebrospinal fluid-contacting neuron tracing reveals structural and functional connectivity for locomotion in the mouse spinal cord.
Nakamura Y, Kurabe M, Matsumoto M, Sato T, Miyashita S, Hoshina K, Kamiya Y, Tainaka K, Matsuzawa H, Ohno N, Ueno M, et al.
eLife (2023) 12: . 147 021 IHC; tested species: mouse
Time-dependent and selective microglia-mediated removal of spinal synapses in neuropathic pain.
Yousefpour N, Locke S, Deamond H, Wang C, Marques L, St-Louis M, Ouellette J, Khoutorsky A, De Koninck Y, Ribeiro-da-Silva A
Cell reports (2023) 421: 112010. 147 021 IHC; tested species: mouse
Neonatal loss of FGFR2 in astroglial cells affects locomotion, sociability, working memory, and glia-neuron interactions in mice.
Stevens HE, Scuderi S, Collica SC, Tomasi S, Horvath TL, Vaccarino FM
Translational psychiatry (2023) 131: 89. 147 021 IHC; tested species: mouse
Acan downregulation in parvalbumin GABAergic cells reduces spontaneous recovery of fear memories.
Lavertu-Jolin M, Chattopadhyaya B, Chehrazi P, Carrier D, Wünnemann F, Leclerc S, Dumouchel F, Robertson D, Affia H, Saba K, Gopal V, et al.
Molecular psychiatry (2023) : . 147 021 IHC; tested species: mouse
Botulinum neurotoxin A ameliorates depressive-like behavior in a reserpine-induced Parkinson's disease mouse model via suppressing hippocampal microglial engulfment and neuroinflammation.
Li Y, Yin Q, Li Q, Huo AR, Shen TT, Cao JQ, Liu CF, Liu T, Luo WF, Cong QF
Acta pharmacologica Sinica (2023) 447: 1322-1336. 147 021 IHC; tested species: mouse
The p75 Neurotrophin Receptor in Preadolescent Prefrontal Parvalbumin Interneurons Promotes Cognitive Flexibility in Adult Mice.
Chehrazi P, Lee KKY, Lavertu-Jolin M, Abbasnejad Z, Carreño-Muñoz MI, Chattopadhyaya B, Di Cristo G
Biological psychiatry (2023) 944: 310-321. 147 021 IHC; tested species: mouse
Prenatal methadone exposure selectively alters protein expression in primary motor cortex: Implications for synaptic function.
Haggerty DL, Grecco GG, Huang JY, Doud EH, Mosley AL, Lu HC, Atwood BK
Frontiers in pharmacology (2023) 14: 1124108. 147 021 IHC; tested species: mouse
Neuronal P2X4 receptor may contribute to peripheral inflammatory pain in rat spinal dorsal horn.
Ducza L, Gajtkó A, Hegedűs K, Bakk E, Kis G, Gaál B, Takács R, Szücs P, Matesz K, Holló K
Frontiers in molecular neuroscience (2023) 16: 1115685. 147 021 IHC; tested species: rat
Glyoxal fixation: An approach to solve immunohistochemical problem in neuroscience research.
Konno K, Yamasaki M, Miyazaki T, Watanabe M
Science advances (2023) 928: eadf7084. 147 021 IHC; tested species: mouse
An inhibitory circuit-based enhancer of DYRK1A function reverses Dyrk1a-associated impairment in social recognition.
Shih YT, Alipio JB, Sahay A
Neuron (2023) 11119: 3084-3101.e5. 147 021 IHC; tested species: mouse
Synaptic mechanisms for associative learning in the cerebellar nuclei.
Broersen R, Albergaria C, Carulli D, Carey MR, Canto CB, De Zeeuw CI
Nature communications (2023) 141: 7459. 147 021 IHC; tested species: mouse
Heterogeneous complement and microglia activation mediates stress-induced synapse loss.
Soteros BM, Tillmon H, Wollet M, General J, Chin H, Lee JB, Carreno FR, Morilak DA, Kim JH, Sia GM
bioRxiv : the preprint server for biology (2023) : . 147 021 IHC; tested species: mouse
Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signalling.
Boyle KA, Polgar E, Gutierrez-Mecinas M, Dickie AC, Cooper AH, Bell AM, Jumolea E, Casas-Benito A, Watanabe M, Hughes DI, Weir GA, et al.
eLife (2023) 12: . 147 021 IHC; tested species: mouse
Rejection of inappropriate synaptic partners in mouse retina mediated by transcellular FLRT2-UNC5 signaling.
Prigge CL, Dembla M, Sharma A, El-Quessny M, Kozlowski C, Paisley CE, Miltner AM, Johnson TM, Della Santina L, Feller MB, Kay JN, et al.
Developmental cell (2023) 5820: 2080-2096.e7. 147 021 IHC; tested species: mouse
Neuronal Activity Changes the Number of Neurons that are Synaptically Connected to OPCs.
Moura D, Parvathaneni A, Sahagun A, Noguchi H, Garcia J, Brennan E, Brock R, Tilton I, Halladay L, Pleasure S, Cocas L, et al.
eNeuro (2023) : . 147 021 IHC; tested species: mouse
Chronic partial TrkB activation reduces seizures and mortality in a mouse model of Dravet syndrome.
Gu F, Parada I, Yang T, Longo FM, Prince DA
Proceedings of the National Academy of Sciences of the United States of America (2022) 1197: . 147 021 IHC; tested species: mouse
Loss of KCC2 in GABAergic Neurons Causes Seizures and an Imbalance of Cortical Interneurons.
Zavalin K, Hassan A, Fu C, Delpire E, Lagrange AH
Frontiers in molecular neuroscience (2022) 15: 826427. 147 021 IHC; tested species: mouse
Different priming states of synaptic vesicles underlie distinct release probabilities at hippocampal excitatory synapses.
Aldahabi M, Balint F, Holderith N, Lorincz A, Reva M, Nusser Z
Neuron (2022) : . 147 021 IHC; tested species: mouse
Prepubescent female rodents have enhanced hippocampal LTP and learning relative to males, reversing in adulthood as inhibition increases.
Le AA, Lauterborn JC, Jia Y, Wang W, Cox CD, Gall CM, Lynch G
Nature neuroscience (2022) 252: 180-190. 147 021 IHC; tested species: rat
Identification of intraneuronal amyloid beta oligomers in locus coeruleus neurons of Alzheimer's patients and their potential impact on inhibitory neurotransmitter receptors and neuronal excitability.
Kelly L, Seifi M, Ma R, Mitchell SJ, Rudolph U, Viola KL, Klein WL, Lambert JJ, Swinny JD
Neuropathology and applied neurobiology (2021) 474: 488-505. 147 021 IHC; tested species: mouse
Total Number and Ratio of GABAergic Neuron Types in the Mouse Lateral and Basal Amygdala.
Vereczki VK, Müller K, Krizsán É, Máté Z, Fekete Z, Rovira-Esteban L, Veres JM, Erdélyi F, Hájos N
The Journal of neuroscience : the official journal of the Society for Neuroscience (2021) 4121: 4575-4595. 147 021 IHC; tested species: mouse
Identification of neural oscillations and epileptiform changes in human brain organoids.
Samarasinghe RA, Miranda OA, Buth JE, Mitchell S, Ferando I, Watanabe M, Allison TF, Kurdian A, Fotion NN, Gandal MJ, Golshani P, et al.
Nature neuroscience (2021) 2410: 1488-1500. 147 021 IHC; tested species: human
PUPIL enables mapping and stamping of transient electrical connectivity in developing nervous systems.
Xie S, Li H, Yao F, Huang J, Yang X, Chen X, Liu Q, Zhuang M, He S
Cell reports (2021) 373: 109853. 147 021 IHC; tested species: mouse
Sex-dependent long-term effects of prepubescent stress on the posterior parietal cortex.
Fariborzi M, Park SB, Ozgur A, Lur G
Neurobiology of stress (2021) 14: 100295. 147 021 IHC; tested species: mouse
Sensitive period for rescuing parvalbumin interneurons connectivity and social behavior deficits caused by TSC1 loss.
Amegandjin CA, Choudhury M, Jadhav V, Carriço JN, Quintal A, Berryer M, Snapyan M, Chattopadhyaya B, Saghatelyan A, Di Cristo G
Nature communications (2021) 121: 3653. 147 021 IHC; tested species: mouse
Tonic GABAergic inhibition, via GABAA receptors containing αβƐ subunits, regulates excitability of ventral tegmental area dopamine neurons.
Tossell K, Dodhia RA, Galet B, Tkachuk O, Ungless MA
The European journal of neuroscience (2021) : . 147 021 IHC; tested species: mouse
Dopamine depletion induces neuron-specific alterations of GABAergic transmission in the mouse striatum.
Boccalaro IL, Schwerdel C, Cristiá-Lara L, Fritschy JM, Rubi L
The European journal of neuroscience (2020) 525: 3353-3374. 147 021 IHC; tested species: mouse
Microglia monitor and protect neuronal function through specialized somatic purinergic junctions.
Cserép C, Pósfai B, Lénárt N, Fekete R, László ZI, Lele Z, Orsolits B, Molnár G, Heindl S, Schwarcz AD, Ujvári K, et al.
Science (New York, N.Y.) (2020) 3676477: 528-537. 147 021 IHC; tested species: mouse
Phrenic-specific transcriptional programs shape respiratory motor output.
Vagnozzi AN, Garg K, Dewitz C, Moore MT, Cregg JM, Jeannotte L, Zampieri N, Landmesser LT, Philippidou P
eLife (2020) 9: . 147 021 IHC; tested species: mouse
Spinal Wnt5a Plays a Key Role in Spinal Dendritic Spine Remodeling in Neuropathic and Inflammatory Pain Models and in the Proalgesic Effects of Peripheral Wnt3a.
Simonetti M, Kuner R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) 4035: 6664-6677. 147 021 IHC; tested species: mouse
The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development.
Cong Q, Soteros BM, Wollet M, Kim JH, Sia GM
Nature neuroscience (2020) : . 147 021 IHC; tested species: mouse
Developmental Regulation of Basket Interneuron Synapses and Behavior through NCAM in Mouse Prefrontal Cortex.
Sullivan CS, Mohan V, Manis PB, Moy SS, Truong Y, Duncan BW, Maness PF
Cerebral cortex (New York, N.Y. : 1991) (2020) : . 147 021 IHC; tested species: mouse
A High-Resolution Method for Quantitative Molecular Analysis of Functionally Characterized Individual Synapses.
Holderith N, Heredi J, Kis V, Nusser Z
Cell reports (2020) 324: 107968. 147 021 IHC; tested species: rat
Expression of protocadherin-γC4 protein in the rat brain.
Miralles CP, Taylor MJ, Bear J, Fekete CD, George S, Li Y, Bonhomme B, Chiou TT, De Blas AL
The Journal of comparative neurology (2019) : . 147 021 IHC; tested species: rat
Expression mapping, quantification, and complex formation of GluD1 and GluD2 glutamate receptors in adult mouse brain.
Nakamoto C, Konno K, Miyazaki T, Nakatsukasa E, Natsume R, Abe M, Kawamura M, Fukazawa Y, Shigemto R, Yamasaki M, Sakimura K, et al.
The Journal of comparative neurology (2019) : . 147 021 IHC; tested species: mouse
Cell type-specific distribution of GABAA receptor subtypes in the mouse dorsal striatum.
Boccalaro IL, Cristiá-Lara L, Schwerdel C, Fritschy JM, Rubi L
The Journal of comparative neurology (2019) : . 147 021 IHC; tested species: mouse
Development of inhibitory synaptic inputs on layer 2/3 pyramidal neurons in the rat medial prefrontal cortex.
Virtanen MA, Lacoh CM, Fiumelli H, Kosel M, Tyagarajan S, de Roo M, Vutskits L
Brain structure & function (2018) 2234: 1999-2012. 147 021 IHC; tested species: rat
Excitatory synaptic dysfunction cell-autonomously decreases inhibitory inputs and disrupts structural and functional plasticity.
He HY, Shen W, Zheng L, Guo X, Cline HT
Nature communications (2018) 91: 2893. 147 021 IHC; tested species: frog
Extrasynaptic homomeric glycine receptors in neurons of the rat trigeminal mesencephalic nucleus.
Bae JY, Lee JS, Ko SJ, Cho YS, Rah JC, Cho HJ, Park MJ, Bae YC
Brain structure & function (2018) : . 147 021 IHC, EM; tested species: rat
Subretinal Human Umbilical Tissue-Derived Cell Transplantation Preserves Retinal Synaptic Connectivity and Attenuates Müller Glial Reactivity.
Koh S, Chen WJ, Dejneka NS, Harris IR, Lu B, Girman S, Saylor J, Wang S, Eroglu C
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3812: 2923-2943. 147 021 IHC; tested species: rat
GABAergic malfunction in the anterior cingulate cortex underlying maternal immune activation-induced social deficits.
Okamoto K, Hitora-Imamura N, Hioki H, Ikegaya Y
Journal of neuroimmunology (2018) 321: 92-96. 147 021 IHC; tested species: mouse
Dynamic Modulation of Mouse Locus Coeruleus Neurons by Vasopressin 1a and 1b Receptors.
Campos-Lira E, Kelly L, Seifi M, Jackson T, Giesecke T, Mutig K, Koshimizu TA, Hernandez VS, Zhang L, Swinny JD
Frontiers in neuroscience (2018) 12: 919. 147 021 IHC; tested species: mouse
Glycine receptors expression in rat spinal cord and dorsal root ganglion in prostaglandin E2 intrathecal injection models.
Wang HC, Cheng KI, Chen PR, Tseng KY, Kwan AL, Chang LL
BMC neuroscience (2018) 191: 72. 147 021 IHC; tested species: rat
Expression of Neurofilament Subunits at Neocortical Glutamatergic and GABAergic Synapses.
Bragina L, Conti F
Frontiers in neuroanatomy (2018) 12: 74. 147 021 WB, IHC; tested species: rat
In vivo transgenic expression of collybistin in neurons of the rat cerebral cortex.
Fekete CD, Goz RU, Dinallo S, Miralles CP, Chiou TT, Bear J, Fiondella CG, LoTurco JJ, De Blas AL
The Journal of comparative neurology (2017) 5255: 1291-1311. 147 021 IHC; tested species: rat
The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn.
Abraira VE, Kuehn ED, Chirila AM, Springel MW, Toliver AA, Zimmerman AL, Orefice LL, Boyle KA, Bai L, Song BJ, Bashista KA, et al.
Cell (2017) 1681-2: 295-310.e19. 147 021 IHC; tested species: mouse
Molecular Dissection of Neuroligin 2 and Slitrk3 Reveals an Essential Framework for GABAergic Synapse Development.
Li J, Han W, Pelkey KA, Duan J, Mao X, Wang YX, Craig MT, Dong L, Petralia RS, McBain CJ, Lu W, et al.
Neuron (2017) 964: 808-826.e8. 147 021 WB, ICC, IHC; tested species: mouse
Early postnatal GABAA receptor modulation reverses deficits in neuronal maturation in a conditional neurodevelopmental mouse model of DISC1.
Saito A, Taniguchi Y, Rannals MD, Merfeld EB, Ballinger MD, Koga M, Ohtani Y, Gurley DA, Sedlak TW, Cross A, Moss SJ, et al.
Molecular psychiatry (2016) 2110: 1449-59. 147 021 IHC
Neuronal Dystroglycan Is Necessary for Formation and Maintenance of Functional CCK-Positive Basket Cell Terminals on Pyramidal Cells.
Früh S, Romanos J, Panzanelli P, Bürgisser D, Tyagarajan SK, Campbell KP, Santello M, Fritschy JM
The Journal of neuroscience : the official journal of the Society for Neuroscience (2016) 3640: 10296-10313. 147 021 IHC; tested species: mouse
Repetitive magnetic stimulation induces plasticity of inhibitory synapses.
Lenz M, Galanis C, Müller-Dahlhaus F, Opitz A, Wierenga CJ, Szabó G, Ziemann U, Deller T, Funke K, Vlachos A
Nature communications (2016) 7: 10020. 147 021 IHC
Forebrain-specific loss of synaptic GABAA receptors results in altered neuronal excitability and synaptic plasticity in mice.
O'Sullivan GA, Jedlicka P, Chen HX, Kalbouneh H, Ippolito A, Deller T, Nawrotzki RA, Kuhse J, Kalaidzidis YL, Kirsch J, Schwarzacher SW, et al.
Molecular and cellular neurosciences (2016) 72: 101-13. 147 021 IHC
Immunostaining for Homer reveals the majority of excitatory synapses in laminae I-III of the mouse spinal dorsal horn.
Gutierrez-Mecinas M, Kuehn ED, Abraira VE, Polgár E, Watanabe M, Todd AJ
Neuroscience (2016) 329: 171-81. 147 021 IHC
In vivo clonal overexpression of neuroligin 3 and neuroligin 2 in neurons of the rat cerebral cortex: Differential effects on GABAergic synapses and neuronal migration.
Fekete CD, Chiou TT, Miralles CP, Harris RS, Fiondella CG, Loturco JJ, De Blas AL
The Journal of comparative neurology (2015) 5239: 1359-78. 147 021 IHC
KCNQ5 K(+) channels control hippocampal synaptic inhibition and fast network oscillations.
Fidzinski P, Korotkova T, Heidenreich M, Maier N, Schuetze S, Kobler O, Zuschratter W, Schmitz D, Ponomarenko A, Jentsch TJ
Nature communications (2015) 6: 6254. 147 021 IHC
Activity-dependent inhibitory synapse remodeling through gephyrin phosphorylation.
Flores CE, Nikonenko I, Mendez P, Fritschy JM, Tyagarajan SK, Muller D
Proceedings of the National Academy of Sciences of the United States of America (2015) 1121: E65-72. 147 021 IHC
Bassoon-disruption slows vesicle replenishment and induces homeostatic plasticity at a CNS synapse.
Mendoza Schulz A, Jing Z, Sánchez Caro JM, Wetzel F, Dresbach T, Strenzke N, Wichmann C, Moser T
The EMBO journal (2014) 335: 512-27. 147 021 IHC
Synaptic recruitment of gephyrin regulates surface GABAA receptor dynamics for the expression of inhibitory LTP.
Petrini EM, Ravasenga T, Hausrat TJ, Iurilli G, Olcese U, Racine V, Sibarita JB, Jacob TC, Moss SJ, Benfenati F, Medini P, et al.
Nature communications (2014) 5: 3921. 147 021 IHC; tested species: mouse
A protocol for concurrent high-quality immunohistochemical and biochemical analyses in adult mouse central nervous system.
Notter T, Panzanelli P, Pfister S, Mircsof D, Fritschy JM
The European journal of neuroscience (2014) 392: 165-75. 147 021 IHC, EM
Brain inflammation induces post-synaptic changes during early synapse formation in adult-born hippocampal neurons.
Chugh D, Nilsson P, Afjei SA, Bakochi A, Ekdahl CT
Experimental neurology (2013) 250: 176-88. 147 021 IHC; tested species: mouse
A dramatic increase of C1q protein in the CNS during normal aging.
Stephan AH, Madison DV, Mateos JM, Fraser DA, Lovelett EA, Coutellier L, Kim L, Tsai HH, Huang EJ, Rowitch DH, Berns DS, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3333: 13460-74. 147 021 IHC; tested species: mouse
Reducing GABAA α5 receptor-mediated inhibition rescues functional and neuromorphological deficits in a mouse model of down syndrome.
Martínez-Cué C, Martínez P, Rueda N, Vidal R, García S, Vidal V, Corrales A, Montero JA, Pazos Á, Flórez J, Gasser R, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 339: 3953-66. 147 021 IHC; tested species: mouse
Amacrine and bipolar inputs to midget and parasol ganglion cells in marmoset retina.
Abbott CJ, Percival KA, Martin PR, Grünert U
Visual neuroscience (2012) 293: 157-68. 147 021 IHC; tested species: marmoset
Altered synaptic properties during integration of adult-born hippocampal neurons following a seizure insult.
Jackson J, Chugh D, Nilsson P, Wood J, Carlström K, Lindvall O, Ekdahl CT
PloS one (2012) 74: e35557. 147 021 IHC
Postsynaptic TrkC and presynaptic PTPσ function as a bidirectional excitatory synaptic organizing complex.
Takahashi H, Arstikaitis P, Prasad T, Bartlett TE, Wang YT, Murphy TH, Craig AM
Neuron (2011) 692: 287-303. 147 021 IHC; tested species: mouse,rat
Age-related changes of glycine receptor at the rat hippocampus: from the embryo to the adult.
Aroeira RI, Ribeiro JA, Sebastião AM, Valente CA
Journal of neurochemistry (2011) 1183: 339-53. 147 021 IHC; tested species: rat
Hyperexcitability, interneurons, and loss of GABAergic synapses in entorhinal cortex in a model of temporal lobe epilepsy.
Kumar SS, Buckmaster PS
The Journal of neuroscience : the official journal of the Society for Neuroscience (2006) 2617: 4613-23. 147 021 IHC; tested species: rat
Structural Heterogeneity of the GABAergic Tripartite Synapse.
Brunskine C, Passlick S, Henneberger C
Cells (2022) 1119: . 147 021 ExM; tested species: mouse
Spatial proteomics in neurons at single-protein resolution.
Unterauer EM, Shetab Boushehri S, Jevdokimenko K, Masullo LA, Ganji M, Sograte-Idrissi S, Kowalewski R, Strauss S, Reinhardt SCM, Perovic A, Marr C, et al.
Cell (2024) 1877: 1785-1800.e16. 147 021 DNA-PAINT; tested species: rat
High-resolution Immunoelectron Microscopy Techniques for Revealing Distinct Subcellular Type 1 Cannabinoid Receptor Domains in Brain.
Puente N, Río IB, Achicallende S, Nahirney PC, Grandes P
Bio-protocol (2019) 92: e3145. 147 021 EM; tested species: mouse
Extrasynaptic homomeric glycine receptors in neurons of the rat trigeminal mesencephalic nucleus.
Bae JY, Lee JS, Ko SJ, Cho YS, Rah JC, Cho HJ, Park MJ, Bae YC
Brain structure & function (2018) : . 147 021 IHC, EM; tested species: rat
A protocol for concurrent high-quality immunohistochemical and biochemical analyses in adult mouse central nervous system.
Notter T, Panzanelli P, Pfister S, Mircsof D, Fritschy JM
The European journal of neuroscience (2014) 392: 165-75. 147 021 IHC, EM
Electron tomography on γ-aminobutyric acid-ergic synapses reveals a discontinuous postsynaptic network of filaments.
Linsalata AE, Chen X, Winters CA, Reese TS
The Journal of comparative neurology (2014) 5224: 921-36. 147 021 EM, ICC; tested species: rat
Background

Gephyrin is a bifunctional protein which is essential for both synaptic clustering of inhibitory neurotransmitter receptors in the central nervous system and the biosynthesis of the molybdenum cofactor (MoCo) in peripheral tissues. It co-purifies with the inhibitory glycine receptor (GlyR) and is expressed abundantly in all brain areas which contain synapses.