Synaptic Systems - Gephyrin

Cat. No.: 147 011

Amount: 100 µg

Price: $435.00

Cat. No. 147 011	100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H₂O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications	WB: not recommended (see remarks) IP: not recommended (see remarks) ICC: 1 : 1000 up to 1 : 2000 gallery IHC: 1 : 1000 up to 1 : 2000 (see remarks) gallery IHC-P: not recommended ExM: yes (see remarks) gallery DNA-PAINT: yes (see remarks) Clarity: 1 : 100 (see remarks) EM: yes
Clone	mAb7a
Subtype	IgG1 (κ light chain)
Immunogen	Nativ Protein corresponding to AA 1 to 768 from rat Gephyrin (UniProt Id: Q03555)
Epitop	AA 264 to 276 from rat Gephyrin (UniProt Id: Q03555)
Reactivity	Reacts with: human (Q9NQX3), rat (Q03555), mouse (Q8BUV3), pig, goldfish, zebrafish, chicken. Other species not tested yet.
Specificity	Specific for the brain specific 93 kDa splice variant phosphorylated at Ser-270. K.O. validated PubMed: 9812897
Remarks	WB: Clone 3B11 (cat. no. 147 111) is highly recommended. IP: Clone 3B11 (cat. no. 147 111) is highly recommended. IHC: Hybridoma supernatant (cat. no. 147 021) highly recommended. For best results use the protocol of Schneider Gasser et al., 2006. ExM: This antibody has been successfully used for the epitope-preserving magnified analysis of the proteome (eMAP) expansion microscopy method (Park et al. 2021. PMID: 34767453). DNA-PAINT: This antibody has been successfully used for DNA-PAINT application (see Unterauer et al., 2024; PMID: 38552614). Clarity: This antibody has been successfully used for CLARITY application in human brain (Woelfle et al., 2023; PMID: 37221592).
Data sheet	147_011.pdf

References for Gephyrin - 147 011

Agathobaculum butyriciproducens improves ageing-associated cognitive impairment in mice.
Go J, Maeng SY, Chang DH, Park HY, Min KS, Kim JE, Choi YK, Noh JR, Ro H, Kim BC, Kim KS, et al.
Life sciences (2024) 339: 122413. 147 011 WB; tested species: mouse

Postweaning Development Influences Endogenous VPAC1 Modulation of LTP Induced by Theta-Burst Stimulation: A Link to Maturation of the Hippocampal GABAergic System.
Gil M, Caulino-Rocha A, Bento M, Rodrigues NC, Silva-Cruz A, Ribeiro JA, Cunha-Reis D
Biomolecules (2024) 143: . 147 011 WB; tested species: rat

Presynapses contain distinct actin nanostructures.
Bingham D, Jakobs CE, Wernert F, Boroni-Rueda F, Jullien N, Schentarra EM, Friedl K, Da Costa Moura J, van Bommel DM, Caillol G, Ogawa Y, et al.
The Journal of cell biology (2023) 22210: . 147 011 WB; tested species: rat

Epileptiform activity influences theta-burst induced LTP in the adult hippocampus: a role for synaptic lipid raft disruption in early metaplasticity?
Carvalho-Rosa JD, Rodrigues NC, Silva-Cruz A, Vaz SH, Cunha-Reis D
Frontiers in cellular neuroscience (2023) 17: 1117697. 147 011 WB; tested species: rat

Brevican, Neurocan, Tenascin-C, and Tenascin-R Act as Important Regulators of the Interplay Between Perineuronal Nets, Synaptic Integrity, Inhibitory Interneurons, and Otx2.
Mueller-Buehl C, Reinhard J, Roll L, Bader V, Winklhofer KF, Faissner A
Frontiers in cell and developmental biology (2022) 10: 886527. 147 011 WB, IHC; tested species: mouse

Binding of gephyrin to microtubules is regulated by its phosphorylation at Ser270.
Zhou L, Kiss E, Demmig R, Kirsch J, Nawrotzki RA, Kuhse J
Histochemistry and cell biology (2021) : . 147 011 WB, ICC; tested species: human,rat

Visual Cortex Engagement in Retinitis Pigmentosa.
Pietra G, Bonifacino T, Talamonti D, Bonanno G, Sale A, Galli L, Baroncelli L
International journal of molecular sciences (2021) 2217: . 147 011 WB; tested species: mouse

Chemico-genetic discovery of astrocytic control of inhibition in vivo.
Takano T, Wallace JT, Baldwin KT, Purkey AM, Uezu A, Courtland JL, Soderblom EJ, Shimogori T, Maness PF, Eroglu C, Soderling SH, et al.
Nature (2020) : . 147 011 WB, ICC; tested species: mouse

Changes in neuronal excitability and synaptic transmission in nucleus accumbens in a transgenic Alzheimer's disease mouse model.
Fernández-Pérez EJ, Gallegos S, Armijo-Weingart L, Araya A, Riffo-Lepe NO, Cayuman F, Aguayo LG
Scientific reports (2020) 101: 19606. 147 011 WB, IHC; tested species: mouse

Autism and Schizophrenia-Associated CYFIP1 Regulates the Balance of Synaptic Excitation and Inhibition.
Davenport EC, Szulc BR, Drew J, Taylor J, Morgan T, Higgs NF, López-Doménech G, Kittler JT
Cell reports (2019) 268: 2037-2051.e6. 147 011 WB, ICC, IHC; tested species: mouse

HIV-1 Tat-Induced Astrocytic Extracellular Vesicle miR-7 Impairs Synaptic Architecture.
Hu G, Niu F, Liao K, Periyasamy P, Sil S, Liu J, Dravid SM, Buch S
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology (2019) : . 147 011 WB, ICC, IHC; tested species: human,rat,monkey

The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation.
Shimell JJ, Shah BS, Cain SM, Thouta S, Kuhlmann N, Tatarnikov I, Jovellar DB, Brigidi GS, Kass J, Milnerwood AJ, Snutch TP, et al.
Cell reports (2019) 298: 2422-2437.e8. 147 011 WB, ICC; tested species: rat

Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission.
Maric HM, Hausrat TJ, Neubert F, Dalby NO, Doose S, Sauer M, Kneussel M, Strømgaard K
Nature chemical biology (2017) 132: 153-160. 147 011 WB, ICC; tested species: mouse

Extracellular signal-regulated kinase and glycogen synthase kinase 3β regulate gephyrin postsynaptic aggregation and GABAergic synaptic function in a calpain-dependent mechanism.
Tyagarajan SK, Ghosh H, Yévenes GE, Imanishi SY, Zeilhofer HU, Gerrits B, Fritschy JM
The Journal of biological chemistry (2013) 28814: 9634-47. 147 011 WB, IP

A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice.
Tabuchi K, Blundell J, Etherton MR, Hammer RE, Liu X, Powell CM, Südhof TC
Science (New York, N.Y.) (2007) 3185847: 71-6. 147 011 WB; tested species: mouse

Ultrastructural characterization of hippocampal inhibitory synapses under resting and stimulated conditions.
Tao-Cheng JH, Moreira SL, Winters CA
Molecular brain (2024) 171: 76. 147 011 ICC; tested species: rat

GLYPHOSATE IMPAIRS BOTH STRUCTURE AND FUNCTION OF GABAERGIC SYNAPSES IN HIPPOCAMPAL NEURONS.
Chiantia G, Comai D, Hidisoglu E, Gurgone A, Franchino C, Carabelli V, Marcantoni A, Giustetto M
Neuropharmacology (2024) : 110183. 147 011 ICC; tested species: mouse

ZCCHC17 knockdown phenocopies Alzheimer's disease-related loss of synaptic proteins and hyperexcitability.
Cortese GP, Bartosch AMW, Xiao H, Gribkova Y, Lam TG, Argyrousi EK, Sivakumar S, Cardona C, Teich AF
Journal of neuropathology and experimental neurology (2024) : . 147 011 ICC; tested species: rat

3D bioprinting of human neural tissues with functional connectivity.
Yan Y, Li X, Gao Y, Mathivanan S, Kong L, Tao Y, Dong Y, Li X, Bhattacharyya A, Zhao X, Zhang SC, et al.
Cell stem cell (2024) 312: 260-274.e7. 147 011 ICC; tested species: human

Converging synaptic and network dysfunctions in distinct autoimmune encephalitis.
Hunter D, Petit-Pedrol M, Fernandes D, Bénac N, Rodrigues C, Kreye J, Ceanga M, Prüss H, Geis C, Groc L
EMBO reports (2024) : . 147 011 ICC; tested species: rat

Role of the Glycine Receptor β Subunit in Synaptic Localization and Pathogenicity in Severe Startle Disease.
Wiessler AL, Hasenmüller AS, Fuhl I, Mille C, Cortes Campo O, Reinhard N, Schenk J, Heinze KG, Schaefer N, Specht CG, Villmann C, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2024) 442: . 147 011 ICC, IHC; tested species: mouse

Generation of glutamatergic/GABAergic neuronal co-cultures derived from human induced pluripotent stem cells for characterizing E/I balance in vitro.
Wang S, Hesen R, Mossink B, Nadif Kasri N, Schubert D
STAR protocols (2023) 41: 101967. 147 011 ICC; tested species: human

Interaction between Teneurin-2 and microtubules via EB proteins provides a platform for GABAA receptor exocytosis.
Ichinose S, Susuki Y, Hosoi N, Kaneko R, Ebihara M, Hirai H, Iwasaki H
eLife (2023) 12: . 147 011 ICC; tested species: mouse

The proteomic landscape of synaptic diversity across brain regions and cell types.
van Oostrum M, Blok TM, Giandomenico SL, Tom Dieck S, Tushev G, Fürst N, Langer JD, Schuman EM
Cell (2023) 18624: 5411-5427.e23. 147 011 ICC; tested species: mouse

Acute reorganization of postsynaptic GABAA receptors reveals the functional impact of molecular nanoarchitecture at inhibitory synapses.
Olah SS, Kareemo DJ, Buchta WC, Sinnen BL, Miller CN, Actor-Engel HS, Gookin SE, Winborn CS, Kleinjan MS, Crosby KC, Aoto J, et al.
Cell reports (2023) 4211: 113331. 147 011 ICC; tested species: rat

Fine-tuning GPCR-mediated neuromodulation by biasing signaling through different G protein subunits.
Park JC, Luebbers A, Dao M, Semeano A, Nguyen AM, Papakonstantinou MP, Broselid S, Yano H, Martemyanov KA, Garcia-Marcos M
Molecular cell (2023) 8314: 2540-2558.e12. 147 011 ICC; tested species: mouse

Btbd11 supports cell-type-specific synaptic function.
Bygrave AM, Sengupta A, Jackert EP, Ahmed M, Adenuga B, Nelson E, Goldschmidt HL, Johnson RC, Zhong H, Yeh FL, Sheng M, et al.
Cell reports (2023) 426: 112591. 147 011 ICC; tested species: rat

Phosphorylation of neuroligin-2 by PKA regulates its cell surface abundance and synaptic stabilization.
Halff EF, Hannan S, Kwanthongdee J, Lesept F, Smart TG, Kittler JT
Science signaling (2022) 15739: eabg2505. 147 011 ICC; tested species: rat

The synaptic scaffold protein MPP2 interacts with GABAA receptors at the periphery of the postsynaptic density of glutamatergic synapses.
Schmerl B, Gimber N, Kuropka B, Stumpf A, Rentsch J, Kunde SA, von Sivers J, Ewers H, Schmitz D, Freund C, Schmoranzer J, et al.
PLoS biology (2022) 203: e3001503. 147 011 ICC; tested species: rat

Patient-derived anti-NMDAR antibody disinhibits cortical neuronal networks through dysfunction of inhibitory neuron output.
Andrzejak E, Rabinovitch E, Kreye J, Prüss H, Rosenmund C, Ziv NE, Garner CC, Ackermann F
The Journal of neuroscience : the official journal of the Society for Neuroscience (2022) : . 147 011 ICC; tested species: mouse

MAD2B promotes podocyte injury through regulating Numb-dependent Notch 1 pathway in diabetic nephropathy.
Li MR, Lei CT, Tang H, Yin XJ, Hao Z, Qiu Y, Xie YR, Zeng JY, Su H, Zhang C
International journal of biological sciences (2022) 185: 1896-1911. 147 011 ICC; tested species: rat

Complementary Use of Super-Resolution Imaging Modalities to Study the Nanoscale Architecture of Inhibitory Synapses.
Gookin SE, Taylor MR, Schwartz SL, Kennedy MJ, Dell'Acqua ML, Crosby KC, Smith KR
Frontiers in synaptic neuroscience (2022) 14: 852227. 147 011 ICC; tested species: rat

LiCl treatment leads to long-term restoration of spine maturation and synaptogenesis in adult Tbr1 mutants.
Fazel Darbandi S, Nelson AD, Pai EL, Bender KJ, Rubenstein JLR
Journal of neurodevelopmental disorders (2022) 141: 11. 147 011 ICC; tested species: mouse

Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through the cAMP/PKA pathway.
Wang S, Rhijn JV, Akkouh I, Kogo N, Maas N, Bleeck A, Ortiz IS, Lewerissa E, Wu KM, Schoenmaker C, Djurovic S, et al.
Cell reports (2022) 395: 110790. 147 011 ICC; tested species: human

Hetero-pentamerization determines mobility and conductance of Glycine receptor α3 splice variants.
Lemmens V, Thevelein B, Vella Y, Kankowski S, Leonhard J, Mizuno H, Rocha S, Brône B, Meier JC, Hendrix J
Cellular and molecular life sciences : CMLS (2022) 7911: 540. 147 011 ICC; tested species: human

Expression analyses of PLEKHG2, a Rho family-specific guanine nucleotide exchange factor, during mouse brain development.
Nishikawa M, Ito H, Noda M, Hamada N, Tabata H, Nagata KI
Medical molecular morphology (2021) 542: 146-155. 147 011 ICC; tested species: mouse

Neuroinflammation induces synaptic scaling through IL-1β-mediated activation of the transcriptional repressor REST/NRSF.
Buffolo F, Petrosino V, Albini M, Moschetta M, Carlini F, Floss T, Kerlero de Rosbo N, Cesca F, Rocchi A, Uccelli A, Benfenati F, et al.
Cell death & disease (2021) 122: 180. 147 011 ICC; tested species: mouse

Differential regulation of glycinergic and GABAergic nanocolumns at mixed inhibitory synapses.
Yang X, Le Corronc H, Legendre P, Triller A, Specht CG
EMBO reports (2021) : e52154. 147 011 ICC; tested species: rat

Pumilio2 and Staufen2 selectively balance the synaptic proteome.
Schieweck R, Riedemann T, Forné I, Harner M, Bauer KE, Rieger D, Ang FY, Hutten S, Demleitner AF, Popper B, Derdak S, et al.
Cell reports (2021) 3512: 109279. 147 011 ICC; tested species: mouse

Action potential-coupled Rho GTPase signaling drives presynaptic plasticity.
O'Neil SD, Rácz B, Brown WE, Gao Y, Soderblom EJ, Yasuda R, Soderling SH
eLife (2021) 10: . 147 011 ICC; tested species: mouse

Npas4 regulates IQSEC3 expression in hippocampal somatostatin interneurons to mediate anxiety-like behavior.
Kim S, Park D, Kim J, Kim D, Kim H, Mori T, Jung H, Lee D, Hong S, Jeon J, Tabuchi K, et al.
Cell reports (2021) 363: 109417. 147 011 ICC; tested species: mouse

An optimized CRISPR/Cas9 approach for precise genome editing in neurons.
Fang H, Bygrave AM, Roth RH, Johnson RC, Huganir RL
eLife (2021) 10: . 147 011 ICC; tested species: mouse

Poly I:C Activated Microglia Disrupt Perineuronal Nets and Modulate Synaptic Balance in Primary Hippocampal Neurons in vitro.
Wegrzyn D, Freund N, Faissner A, Juckel G
Frontiers in synaptic neuroscience (2021) 13: 637549. 147 011 ICC; tested species: mouse

Precision Mapping of Amyloid-β Binding Reveals Perisynaptic Localization and Spatially Restricted Plasticity Deficits.
Actor-Engel HS, Schwartz SL, Crosby KC, Sinnen BL, Prikhodko O, Ramsay HJ, Bourne JN, Winborn CS, Lucas A, Smith KR, Dell'Acqua ML, et al.
eNeuro (2021) : . 147 011 ICC; tested species: rat

Phospholipid-flippase chaperone CDC50A is required for synapse maintenance by regulating phosphatidylserine exposure.
Li T, Yu D, Oak HC, Zhu B, Wang L, Jiang X, Molday RS, Kriegstein A, Piao X
The EMBO journal (2021) 4021: e107915. 147 011 ICC; tested species: mouse

REST/NRSF drives homeostatic plasticity of inhibitory synapses in a target-dependent fashion.
Prestigio C, Ferrante D, Marte A, Romei A, Lignani G, Onofri F, Valente P, Benfenati F, Baldelli P
eLife (2021) 10: . 147 011 ICC; tested species: mouse

Stepwise disassembly of GABAergic synapses during pathogenic excitotoxicity.
Garcia JD, Gookin SE, Crosby KC, Schwartz SL, Tiemeier E, Kennedy MJ, Dell'Acqua ML, Herson PS, Quillinan N, Smith KR
Cell reports (2021) 3712: 110142. 147 011 ICC; tested species: rat

PKC-phosphorylation of Liprin-α3 triggers phase separation and controls presynaptic active zone structure.
Emperador-Melero J, Wong MY, Wang SSH, de Nola G, Nyitrai H, Kirchhausen T, Kaeser PS
Nature communications (2021) 121: 3057. 147 011 ICC; tested species: mouse

Activity- and sleep-dependent regulation of tonic inhibition by Shisa7.
Wu K, Han W, Tian Q, Li Y, Lu W
Cell reports (2021) 3412: 108899. 147 011 ICC; tested species: mouse

A GTPase-induced switch in phospholipid affinity of collybistin contributes to synaptic gephyrin clustering.
Kilisch M, Mayer S, Mitkovski M, Roehse H, Hentrich J, Schwappach B, Papadopoulos T
Journal of cell science (2020) : . 147 011 ICC; tested species: rat

Opposite Control of Excitatory and Inhibitory Synapse Formation by Slitrk2 and Slitrk5 on Dopamine Neurons Modulates Hyperactivity Behavior.
Salesse C, Charest J, Doucet-Beaupré H, Castonguay AM, Labrecque S, De Koninck P, Lévesque M
Cell reports (2020) 307: 2374-2386.e5. 147 011 ICC; tested species: mouse

Activated microglia cause metabolic disruptions in developmental cortical interneurons that persist in interneurons from individuals with schizophrenia.
Park GH, Noh H, Shao Z, Ni P, Qin Y, Liu D, Beaudreault CP, Park JS, Abani CP, Park JM, Le DT, et al.
Nature neuroscience (2020) 2311: 1352-1364. 147 011 ICC; tested species: human

Poly I:C induced maternal immune challenge reduces perineuronal net area and raises spontaneous network activity of hippocampal neurons in vitro.
Wegrzyn D, Manitz MP, Kostka M, Freund N, Juckel G, Faissner A
The European journal of neuroscience (2020) : . 147 011 ICC; tested species: mouse

Local miRNA-Dependent Translational Control of GABAAR Synthesis during Inhibitory Long-Term Potentiation.
Rajgor D, Purkey AM, Sanderson JL, Welle TM, Garcia JD, Dell'Acqua ML, Smith KR
Cell reports (2020) 3112: 107785. 147 011 ICC; tested species: rat

Imbalance of Excitatory/Inhibitory Neuron Differentiation in Neurodevelopmental Disorders with an NR2F1 Point Mutation.
Zhang K, Yu F, Zhu J, Han S, Chen J, Wu X, Chen Y, Shen T, Liao J, Guo W, Yang X, et al.
Cell reports (2020) 313: 107521. 147 011 ICC; tested species: human

Acute knockdown of Depdc5 leads to synaptic defects in mTOR-related epileptogenesis.
De Fusco A, Cerullo MS, Marte A, Michetti C, Romei A, Castroflorio E, Baulac S, Benfenati F
Neurobiology of disease (2020) : 104822. 147 011 ICC; tested species: mouse

Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins.
Kasaragod VB, Hausrat TJ, Schaefer N, Kuhn M, Christensen NR, Tessmer I, Maric HM, Madsen KL, Sotriffer C, Villmann C, Kneussel M, et al.
Neuron (2019) 1014: 673-689.e11. 147 011 ICC; tested species: mouse

Biallelic DMXL2 mutations impair autophagy and cause Ohtahara syndrome with progressive course.
Esposito A, Falace A, Wagner M, Gal M, Mei D, Conti V, Pisano T, Aprile D, Cerullo MS, De Fusco A, Giovedì S, et al.
Brain : a journal of neurology (2019) : . 147 011 ICC; tested species: mouse

SNX27-Mediated Recycling of Neuroligin-2 Regulates Inhibitory Signaling.
Halff EF, Szulc BR, Lesept F, Kittler JT
Cell reports (2019) 299: 2599-2607.e6. 147 011 ICC; tested species: rat

Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses.
Gottschling C, Wegrzyn D, Denecke B, Faissner A
Scientific reports (2019) 91: 13939. 147 011 ICC; tested species: mouse

Regulation of dendrite morphology and excitatory synapse formation by zDHHC15.
Shah BS, Shimell JJ, Bamji SX
Journal of cell science (2019) 13213: . 147 011 ICC; tested species: rat

βPix heterozygous mice have defects in neuronal morphology and social interaction.
Kwon Y, Lee SJ, Lee E, Kim D, Park D
Biochemical and biophysical research communications (2019) 5164: 1204-1210. 147 011 ICC; tested species: mouse

Nanoscale Subsynaptic Domains Underlie the Organization of the Inhibitory Synapse.
Crosby KC, Gookin SE, Garcia JD, Hahm KM, Dell'Acqua ML, Smith KR
Cell reports (2019) 2612: 3284-3297.e3. 147 011 ICC, IHC; tested species: rat

Essential role for InSyn1 in dystroglycan complex integrity and cognitive behaviors in mice.
Uezu A, Hisey E, Kobayashi Y, Gao Y, Bradshaw TW, Devlin P, Rodriguiz R, Tata PR, Soderling S
eLife (2019) 8: . 147 011 ICC; tested species: mouse

Neuroligin-4 Regulates Excitatory Synaptic Transmission in Human Neurons.
Marro SG, Chanda S, Yang N, Janas JA, Valperga G, Trotter J, Zhou B, Merrill S, Yousif I, Shelby H, Vogel H, et al.
Neuron (2019) 1034: 617-626.e6. 147 011 ICC; tested species: human

Depolarizing, inhibitory GABA type A receptor activity regulates GABAergic synapse plasticity via ERK and BDNF signaling.
Brady ML, Pilli J, Lorenz-Guertin JM, Das S, Moon CE, Graff N, Jacob TC
Neuropharmacology (2018) 128: 324-339. 147 011 ICC; tested species: rat

Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies.
Dejanovic B, Huntley MA, De Mazière A, Meilandt WJ, Wu T, Srinivasan K, Jiang Z, Gandham V, Friedman BA, Ngu H, Foreman O, et al.
Neuron (2018) : . 147 011 ICC; tested species: mouse

Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting.
Awasthi A, Ramachandran B, Ahmed S, Benito E, Shinoda Y, Nitzan N, Heukamp A, Rannio S, Martens H, Barth J, Burk K, et al.
Science (New York, N.Y.) (2018) : . 147 011 ICC; tested species: rat

Prions activate a p38 MAPK synaptotoxic signaling pathway.
Fang C, Wu B, Le NTT, Imberdis T, Mercer RCC, Harris DA
PLoS pathogens (2018) 149: e1007283. 147 011 ICC; tested species: mouse

Clptm1 Limits Forward Trafficking of GABAA Receptors to Scale Inhibitory Synaptic Strength.
Ge Y, Kang Y, Cassidy RM, Moon KM, Lewis R, Wong ROL, Foster LJ, Craig AM
Neuron (2018) 973: 596-610.e8. 147 011 ICC, IHC; tested species: mouse

GARLH Family Proteins Stabilize GABAA Receptors at Synapses.
Yamasaki T, Hoyos-Ramirez E, Martenson JS, Morimoto-Tomita M, Tomita S
Neuron (2017) 935: 1138-1152.e6. 147 011 ICC

Adaptive-illumination STED nanoscopy.
Heine J, Reuss M, Harke B, D'Este E, Sahl SJ, Hell SW
Proceedings of the National Academy of Sciences of the United States of America (2017) 11437: 9797-9802. 147 011 ICC; tested species: rat

Nanoscale Molecular Reorganization of the Inhibitory Postsynaptic Density Is a Determinant of GABAergic Synaptic Potentiation.
Pennacchietti F, Vascon S, Nieus T, Rosillo C, Das S, Tyagarajan SK, Diaspro A, Del Bue A, Petrini EM, Barberis A, Cella Zanacchi F, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2017) 377: 1747-1756. 147 011 ICC

Alpha subunit-dependent glycine receptor clustering and regulation of synaptic receptor numbers.
Patrizio A, Renner M, Pizzarelli R, Triller A, Specht CG
Scientific reports (2017) 71: 10899. 147 011 ICC; tested species: rat

The antipsychotic drugs olanzapine and haloperidol modify network connectivity and spontaneous activity of neural networks in vitro.
Dzyubenko E, Juckel G, Faissner A
Scientific reports (2017) 71: 11609. 147 011 ICC; tested species: mouse

Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory.
Hausrat TJ, Muhia M, Gerrow K, Thomas P, Hirdes W, Tsukita S, Heisler FF, Herich L, Dubroqua S, Breiden P, Feldon J, et al.
Nature communications (2015) 6: 6872. 147 011 ICC

A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling.
Vullhorst D, Mitchell RM, Keating C, Roychowdhury S, Karavanova I, Tao-Cheng JH, Buonanno A
Nature communications (2015) 6: 7222. 147 011 ICC

Plexin-B3 suppresses excitatory and promotes inhibitory synapse formation in rat hippocampal neurons.
Laht P, Tammaru E, Otsus M, Rohtla J, Tiismus L, Veske A
Experimental cell research (2015) 3352: 269-78. 147 011 ICC

Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2/Caspr2 knockout neurons.
Varea O, Martin-de-Saavedra MD, Kopeikina KJ, Schürmann B, Fleming HJ, Fawcett-Patel JM, Bach A, Jang S, Peles E, Kim E, Penzes P, et al.
Proceedings of the National Academy of Sciences of the United States of America (2015) 11219: 6176-81. 147 011 ICC

Super-Resolution Microscopy Reveals Presynaptic Localization of the ALS/FTD Related Protein FUS in Hippocampal Neurons.
Schoen M, Reichel JM, Demestre M, Putz S, Deshpande D, Proepper C, Liebau S, Schmeisser MJ, Ludolph AC, Michaelis J, Boeckers TM, et al.
Frontiers in cellular neuroscience (2015) 9: 496. 147 011 ICC; tested species: rat

Activity-regulated trafficking of the palmitoyl-acyl transferase DHHC5.
Brigidi GS, Santyr B, Shimell J, Jovellar B, Bamji SX
Nature communications (2015) 6: 8200. 147 011 ICC

Lipid binding defects and perturbed synaptogenic activity of a Collybistin R290H mutant that causes epilepsy and intellectual disability.
Papadopoulos T, Schemm R, Grubmüller H, Brose N
The Journal of biological chemistry (2015) 29013: 8256-70. 147 011 ICC

Synaptic recruitment of gephyrin regulates surface GABAA receptor dynamics for the expression of inhibitory LTP.
Petrini EM, Ravasenga T, Hausrat TJ, Iurilli G, Olcese U, Racine V, Sibarita JB, Jacob TC, Moss SJ, Benfenati F, Medini P, et al.
Nature communications (2014) 5: 3921. 147 011 ICC; tested species: mouse

Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization.
Wang SH, Celic I, Choi SY, Riccomagno M, Wang Q, Sun LO, Mitchell SP, Vasioukhin V, Huganir RL, Kolodkin AL
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3438: 12745-61. 147 011 ICC; tested species: mouse

High content image analysis identifies novel regulators of synaptogenesis in a high-throughput RNAi screen of primary neurons.
Nieland TJ, Logan DJ, Saulnier J, Lam D, Johnson C, Root DE, Carpenter AE, Sabatini BL
PloS one (2014) 93: e91744. 147 011 ICC; tested species: mouse

Genetic evidence for the adhesion protein IgSF9/Dasm1 to regulate inhibitory synapse development independent of its intracellular domain.
Mishra A, Traut MH, Becker L, Klopstock T, Stein V, Klein R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3412: 4187-99. 147 011 ICC, IHC; tested species: mouse

Proteomic analysis of glycine receptor β subunit (GlyRβ)-interacting proteins: evidence for syndapin I regulating synaptic glycine receptors.
Del Pino I, Koch D, Schemm R, Qualmann B, Betz H, Paarmann I
The Journal of biological chemistry (2014) 28916: 11396-409. 147 011 ICC; tested species: rat

TNF-α downregulates inhibitory neurotransmission through protein phosphatase 1-dependent trafficking of GABA(A) receptors.
Pribiag H, Stellwagen D
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3340: 15879-93. 147 011 ICC; tested species: rat

Quantitative nanoscopy of inhibitory synapses: counting gephyrin molecules and receptor binding sites.
Specht CG, Izeddin I, Rodriguez PC, El Beheiry M, Rostaing P, Darzacq X, Dahan M, Triller A
Neuron (2013) 792: 308-21. 147 011 ICC; tested species: mouse

Differential control of thrombospondin over synaptic glycine and AMPA receptors in spinal cord neurons.
Hennekinne L, Colasse S, Triller A, Renner M
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3328: 11432-9. 147 011 ICC; tested species: rat

Tracing synaptic connectivity onto embryonic stem cell-derived neurons.
Garcia I, Huang L, Ung K, Arenkiel BR
Stem cells (Dayton, Ohio) (2012) 3010: 2140-51. 147 011 ICC; tested species: mouse

Effects of distinct collybistin isoforms on the formation of GABAergic synapses in hippocampal neurons.
Körber C, Richter A, Kaiser M, Schlicksupp A, Mükusch S, Kuner T, Kirsch J, Kuhse J
Molecular and cellular neurosciences (2012) 503-4: 250-9. 147 011 ICC

Molecular basis of the γ-aminobutyric acid A receptor α3 subunit interaction with the clustering protein gephyrin.
Tretter V, Kerschner B, Milenkovic I, Ramsden SL, Ramerstorfer J, Saiepour L, Maric HM, Moss SJ, Schindelin H, Harvey RJ, Sieghart W, et al.
The Journal of biological chemistry (2011) 28643: 37702-11. 147 011 ICC; tested species: mouse

Irregular RNA splicing curtails postsynaptic gephyrin in the cornu ammonis of patients with epilepsy.
Förstera B, Belaidi AA, Jüttner R, Bernert C, Tsokos M, Lehmann TN, Horn P, Dehnicke C, Schwarz G, Meier JC
Brain : a journal of neurology (2010) 133Pt 12: 3778-94. 147 011 ICC

Astrocyte secreted proteins selectively increase hippocampal GABAergic axon length, branching, and synaptogenesis.
Hughes EG, Elmariah SB, Balice-Gordon RJ
Molecular and cellular neurosciences (2010) 431: 136-45. 147 011 ICC; tested species: rat

Induction of GABAergic postsynaptic differentiation by alpha-neurexins.
Kang Y, Zhang X, Dobie F, Wu H, Craig AM
The Journal of biological chemistry (2008) 2834: 2323-34. 147 011 ICC; tested species: rat

Activity-dependent regulation of inhibitory synaptic transmission in hippocampal neurons.
Hartman KN, Pal SK, Burrone J, Murthy VN
Nature neuroscience (2006) 95: 642-9. 147 011 ICC

Structure function and splice site analysis of the synaptogenic activity of the neurexin-1 beta LNS domain.
Graf ER, Kang Y, Hauner AM, Craig AM
The Journal of neuroscience : the official journal of the Society for Neuroscience (2006) 2616: 4256-65. 147 011 ICC

Neuronal cotransport of glycine receptor and the scaffold protein gephyrin.
Maas C, Tagnaouti N, Loebrich S, Behrend B, Lappe-Siefke C, Kneussel M
The Journal of cell biology (2006) 1723: 441-51. 147 011 ICC

Gephyrin regulates the cell surface dynamics of synaptic GABAA receptors.
Jacob TC, Bogdanov YD, Magnus C, Saliba RS, Kittler JT, Haydon PG, Moss SJ
The Journal of neuroscience : the official journal of the Society for Neuroscience (2005) 2545: 10469-78. 147 011 ICC

A gephyrin-related mechanism restraining glycine receptor anchoring at GABAergic synapses.
Meier J, Grantyn R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2004) 246: 1398-405. 147 011 ICC

GSK3 and KIF5 regulate activity-dependent sorting of gephyrin between axons and dendrites.
Rathgeber L, Gromova KV, Schaefer I, Breiden P, Lohr C, Kneussel M
European journal of cell biology () 943-4: 173-8. 147 011 ICC

Cell-autonomous reduction of CYFIP2 changes dendrite length, dendritic protrusion morphology, and inhibitory synapse density in the hippocampal CA1 pyramidal neurons of 17-month-old mice.
Kim Y, Ma R, Zhang Y, Kang HR, Kim US, Han K
Animal cells and systems (2024) 281: 294-302. 147 011 IHC; tested species: mouse

Early cortical GABAergic interneurons determine the projection patterns of L4 excitatory neurons.
Bragg-Gonzalo L, Aguilera A, González-Arias C, De León Reyes NS, Sánchez-Cruz A, Carballeira P, Leroy F, Perea G, Nieto M
Science advances (2024) 1019: eadj9911. 147 011 IHC; tested species: mouse

Microglia enhance post-anesthesia neuronal activity by shielding inhibitory synapses.
Haruwaka K, Ying Y, Liang Y, Umpierre AD, Yi MH, Kremen V, Chen T, Xie T, Qi F, Zhao S, Zheng J, et al.
Nature neuroscience (2024) 273: 449-461. 147 011 IHC; tested species: mouse

Synaptic input and Ca2+ activity in zebrafish oligodendrocyte precursor cells contribute to myelin sheath formation.
Li J, Miramontes TG, Czopka T, Monk KR
Nature neuroscience (2024) 272: 219-231. 147 011 IHC; tested species: zebrafish

Effects of estradiol on dopaminergic synapse formation in the mouse olfactory bulb.
Kiyokage E, Ichikawa S, Horie S, Hayashi S, Toida K
The Journal of comparative neurology (2023) 5314: 528-547. 147 011 IHC; tested species: mouse

Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines.
Licht-Murava A, Meadows SM, Palaguachi F, Song SC, Jackvony S, Bram Y, Zhou C, Schwartz RE, Froemke RC, Orr AL, Orr AG, et al.
Science advances (2023) 916: eade1282. 147 011 IHC; tested species: mouse

GEARBOCS: An Adeno Associated Virus Tool for In Vivo Gene Editing in Astrocytes.
Bindu DS, Tan CX, Savage JT, Eroglu C
bioRxiv : the preprint server for biology (2023) : . 147 011 IHC; tested species: mouse

Antibody-directed extracellular proximity biotinylation reveals that Contactin-1 regulates axo-axonic innervation of axon initial segments.
Ogawa Y, Lim BC, George S, Oses-Prieto JA, Rasband JM, Eshed-Eisenbach Y, Hamdan H, Nair S, Boato F, Peles E, Burlingame AL, et al.
Nature communications (2023) 141: 6797. 147 011 IHC; tested species: rat

Prefrontal microglia deficiency during adolescence disrupts adult cognitive functions and synaptic structures: A follow-up study in female mice.
von Arx AS, Dawson K, Lin HY, Mattei D, Notter T, Meyer U, Schalbetter SM
Brain, behavior, and immunity (2023) 111: 230-246. 147 011 IHC; tested species: mouse

Generation of mouse hippocampal brain organoids from primary embryonic neural stem cells.
Ciarpella F, Zamfir RG, Campanelli A, Pedrotti G, Di Chio M, Bottani E, Decimo I
STAR protocols (2023) 43: 102413. 147 011 IHC; tested species: mouse

Nova proteins direct synaptic integration of somatostatin interneurons through activity-dependent alternative splicing.
Ibrahim LA, Wamsley B, Alghamdi N, Yusuf N, Sevier E, Hairston A, Sherer M, Jaglin XH, Xu Q, Guo L, Khodadadi-Jamayran A, et al.
eLife (2023) 12: . 147 011 IHC; tested species: mouse

In vivo functional characterization of EGFR variants identifies novel drivers of glioblastoma.
Yu K, Kong K, Lozzi B, Luna-Figueroa E, Cervantes A, Curry R, Mohila CA, Rao G, Jalali A, Mills GB, Scott KL, et al.
Neuro-oncology (2023) 253: 471-481. 147 011 IHC; tested species: mouse

Derivation of Sendai-Virus-Reprogrammed Human iPSCs-Neuronal Precursors: In Vitro and In Vivo Post-grafting Safety Characterization.
Shigyo M, Kobayashi Y, Platoshyn O, Marsala S, Kato T, Takamura N, Yoshida K, Kishino A, Bravo-Hernandez M, Juhas S, Juhasova J, et al.
Cell transplantation (2023) 32: 9636897231163232. 147 011 IHC; tested species: human

Targeted proteoform mapping uncovers specific Neurexin-3 variants required for dendritic inhibition.
Hauser D, Behr K, Konno K, Schreiner D, Schmidt A, Watanabe M, Bischofberger J, Scheiffele P
Neuron (2022) 11013: 2094-2109.e10. 147 011 IHC; tested species: mouse

Increasing astrogenesis in the developing hippocampus induces autistic-like behavior in mice via enhancing inhibitory synaptic transmission.
Chen J, Ma XL, Zhao H, Wang XY, Xu MX, Wang H, Yang TQ, Peng C, Liu SS, Huang M, Zhou YD, et al.
Glia (2022) 701: 106-122. 147 011 IHC; tested species: mouse

Fat3 acts through independent cytoskeletal effectors to coordinate asymmetric cell behaviors during polarized circuit assembly.
Avilés EC, Krol A, Henle SJ, Burroughs-Garcia J, Deans MR, Goodrich LV
Cell reports (2022) 385: 110307. 147 011 IHC; tested species: mouse

An adult-stage transcriptional program for survival of serotonergic connectivity.
Kitt MM, Tabuchi N, Spencer WC, Robinson HL, Zhang XL, Eastman BA, Lobur KJ, Silver J, Mei L, Deneris ES
Cell reports (2022) 393: 110711. 147 011 IHC; tested species: mouse

NaV1.1 haploinsufficiency impairs glutamatergic and GABAergic neuron function in the thalamus.
Studtmann C, Ladislav M, Topolski MA, Safari M, Swanger SA
Neurobiology of disease (2022) 167: 105672. 147 011 IHC; tested species: mouse

Hippocampal Excitatory Synaptic Transmission and Plasticity Are Differentially Altered during Postnatal Development by Loss of the X-Linked Intellectual Disability Protein Oligophrenin-1.
Cresto N, Lebrun N, Dumont F, Letourneur F, Billuart P, Rouach N
Cells (2022) 119: . 147 011 IHC; tested species: mouse

Microglia contribute to the postnatal development of cortical somatostatin-positive inhibitory cells and to whisker-evoked cortical activity.
Gesuita L, Cavaccini A, Argunsah AÖ, Favuzzi E, Ibrahim LA, Stachniak TJ, De Gennaro M, Utz S, Greter M, Karayannis T
Cell reports (2022) 407: 111209. 147 011 IHC; tested species: mouse

Pharmacological signature and target-specificity of inhibitory circuits formed by Martinotti cells in the mouse barrel cortex.
Donato C, Victorino DB, Cabezas C, Aguirre A, Lourenço J, Potier MC, de San Martin JZ, Bacci A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2022) : . 147 011 IHC; tested species: mouse

Dendritic Inhibition by Shh Signaling-Dependent Stellate Cell Pool Is Critical for Motor Learning.
Li W, Chen L, Fleming JT, Brignola E, Zavalin K, Lagrange A, Rex T, Heiney SA, Wojaczynski GJ, Medina JF, Chiang C, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2022) 4226: 5130-5143. 147 011 IHC; tested species: mouse

Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice.
Yoshida T, Yamagata A, Imai A, Kim J, Izumi H, Nakashima S, Shiroshima T, Maeda A, Iwasawa-Okamoto S, Azechi K, Osaka F, et al.
Nature communications (2021) 121: 1848. 147 011 IHC; tested species: mouse

Mu Opioid Receptor (Oprm1) Copy Number Influences Nucleus Accumbens Microcircuitry and Reciprocal Social Behaviors.
Toddes C, Lefevre EM, Brandner DD, Zugschwert L, Rothwell PE
The Journal of neuroscience : the official journal of the Society for Neuroscience (2021) : . 147 011 IHC; tested species: mouse

The γ-Protocadherins Interact Physically and Functionally with Neuroligin-2 to Negatively Regulate Inhibitory Synapse Density and Are Required for Normal Social Interaction.
Steffen DM, Ferri SL, Marcucci CG, Blocklinger KL, Molumby MJ, Abel T, Weiner JA
Molecular neurobiology (2021) 586: 2574-2589. 147 011 IHC; tested species: mouse

Inhibitory control in neuronal networks relies on the extracellular matrix integrity.
Dzyubenko E, Fleischer M, Manrique-Castano D, Borbor M, Kleinschnitz C, Faissner A, Hermann DM
Cellular and molecular life sciences : CMLS (2021) 7814: 5647-5663. 147 011 IHC; tested species: mouse

NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety.
Zhang X, Liu Y, Hong X, Li X, Meshul CK, Moore C, Yang Y, Han Y, Li WG, Qi X, Lou H, et al.
Nature communications (2021) 121: 5740. 147 011 IHC; tested species: mouse

Brain volume increase and neuronal plasticity underly predator-induced morphological defense expression in Daphnia longicephala.
Graeve A, Ioannidou I, Reinhard J, Görl DM, Faissner A, Weiss LC
Scientific reports (2021) 111: 12612. 147 011 IHC

Hominini-specific regulation of CBLN2 increases prefrontal spinogenesis.
Shibata M, Pattabiraman K, Muchnik SK, Kaur N, Morozov YM, Cheng X, Waxman SG, Sestan N
Nature (2021) 5987881: 489-494. 147 011 IHC; tested species: mouse

Artemisinin-treatment in pre-symptomatic APP-PS1 mice increases gephyrin phosphorylation at Ser270: a modification regulating postsynaptic GABAAR density.
Kiss E, Kins S, Gorgas K, Orlik M, Fischer C, Endres K, Schlicksupp A, Kirsch J, Kuhse J
Biological chemistry (2021) : . 147 011 IHC; tested species: mouse

Multiomics of synaptic junctions reveals altered lipid metabolism and signaling following environmental enrichment.
Borgmeyer M, Coman C, Has C, Schött HF, Li T, Westhoff P, Cheung YFH, Hoffmann N, Yuanxiang P, Behnisch T, Gomes GM, et al.
Cell reports (2021) 371: 109797. 147 011 IHC; tested species: mouse

Striatal Direct Pathway Targets Npas1+ Pallidal Neurons.
Cui Q, Du X, Chang IYM, Pamukcu A, Lilascharoen V, Berceau BL, García D, Hong D, Chon U, Narayanan A, Kim Y, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2021) 4118: 3966-3987. 147 011 IHC; tested species: mouse

Glycinergic axonal inhibition subserves acute spatial sensitivity to sudden increases in sound intensity.
Franken TP, Bondy BJ, Haimes DB, Goldwyn JH, Golding NL, Smith PH, Joris PX
eLife (2021) 10: . 147 011 IHC

Lunatic Fringe-GFP Marks Lamina-Specific Astrocytes That Regulate Sensory Processing.
Akdemir ES, Woo J, Bosquez Huerta NA, Lozzi B, Groves AK, Harmanci AS, Deneen B
The Journal of neuroscience : the official journal of the Society for Neuroscience (2021) : . 147 011 IHC; tested species: mouse

Axonal CB1 Receptors Mediate Inhibitory Bouton Formation via cAMP Increase and PKA.
Liang J, Kruijssen DLH, Verschuuren ACJ, Voesenek BJB, Benavides FFW, Sáez Gonzalez M, Ruiter M, Wierenga CJ
The Journal of neuroscience : the official journal of the Society for Neuroscience (2021) 4140: 8279-8296. 147 011 IHC; tested species: mouse

Volumetric super-resolution imaging by serial ultrasectioning and stochastic optical reconstruction microscopy in mouse neural tissue.
Vatan T, Minehart JA, Zhang C, Agarwal V, Yang J, Speer CM
STAR protocols (2021) 24: 100971. 147 011 IHC; tested species: mouse

Murine cerebral organoids develop network of functional neurons and hippocampal brain region identity.
Ciarpella F, Zamfir RG, Campanelli A, Ren E, Pedrotti G, Bottani E, Borioli A, Caron D, Di Chio M, Dolci S, Ahtiainen A, et al.
iScience (2021) 2412: 103438. 147 011 IHC; tested species: mouse

GABA-receptive microglia selectively sculpt developing inhibitory circuits.
Favuzzi E, Huang S, Saldi GA, Binan L, Ibrahim LA, Fernández-Otero M, Cao Y, Zeine A, Sefah A, Zheng K, Xu Q, et al.
Cell (2021) 18415: 4048-4063.e32. 147 011 IHC; tested species: mouse

Identification of a stereotypic molecular arrangement of endogenous glycine receptors at spinal cord synapses.
Maynard S, Rostaing P, Schaefer N, Gemin O, Candat A, Dumoulin A, Villmann C, Triller A, Specht CG
eLife (2021) 10: . 147 011 IHC; tested species: mouse

Glutamate transporter 1-expressing glia in the rat substantia nigra-Morphometric analysis and relationships to synapses.
Kessler JP, Salin P, Kerkerian-Le Goff L
Glia (2020) : . 147 011 IHC; tested species: rat

Subcellular sorting of neuregulins controls the assembly of excitatory-inhibitory cortical circuits.
Exposito-Alonso D, Osório C, Bernard C, Pascual-García S, Del Pino I, Marín O, Rico B
eLife (2020) 9: . 147 011 IHC; tested species: mouse

Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer's disease.
Richetin K, Steullet P, Pachoud M, Perbet R, Parietti E, Maheswaran M, Eddarkaoui S, Bégard S, Pythoud C, Rey M, Caillierez R, et al.
Nature neuroscience (2020) 2312: 1567-1579. 147 011 IHC; tested species: mouse

Role of endocannabinoid signaling in a septohabenular pathway in the regulation of anxiety- and depressive-like behavior.
Vickstrom CR, Liu X, Liu S, Hu MM, Mu L, Hu Y, Yu H, Love SL, Hillard CJ, Liu QS
Molecular psychiatry (2020) : . 147 011 IHC; tested species: mouse

SEQUIN Multiscale Imaging of Mammalian Central Synapses Reveals Loss of Synaptic Connectivity Resulting from Diffuse Traumatic Brain Injury.
Sauerbeck AD, Gangolli M, Reitz SJ, Salyards MH, Kim SH, Hemingway C, Gratuze M, Makkapati T, Kerschensteiner M, Holtzman DM, Brody DL, et al.
Neuron (2020) 1072: 257-273.e5. 147 011 IHC; tested species: mouse

Piriform cortex alterations in the Ts65Dn model for down syndrome.
Carbonell J, Blasco-Ibáñez JM, Crespo C, Nácher J, Varea E
Brain research (2020) 1747: 147031. 147 011 IHC; tested species: mouse

Semilunar granule cells are the primary source of the perisomatic excitatory innervation onto parvalbumin-expressing interneurons in the dentate gyrus.
Rovira-Esteban L, Hájos N, Nagy GA, Crespo C, Nacher J, Varea E, Blasco-Ibáñez JM
eNeuro (2020) : . 147 011 IHC; tested species: mouse

Dynamics of the Fragile X Mental Retardation Protein Correlates with Cellular and Synaptic Properties in Primary Auditory Neurons following Afferent Deprivation.
Yu X, Wang X, Sakano H, Zorio DAR, Wang Y
The Journal of comparative neurology (2020) : . 147 011 IHC; tested species: chicken

Enhancing WNT Signaling Restores Cortical Neuronal Spine Maturation and Synaptogenesis in Tbr1 Mutants.
Fazel Darbandi S, Robinson Schwartz SE, Pai EL, Everitt A, Turner ML, Cheyette BNR, Willsey AJ, State MW, Sohal VS, Rubenstein JLR
Cell reports (2020) 312: 107495. 147 011 IHC; tested species: mouse

Neurotransmitters and motoneuron contacts of multifunctional and behaviorally specialized turtle spinal cord interneurons.
Bannatyne BA, Hao 郝赵哲 ZZ, Dyer GMC, Watanabe M, Maxwell DJ, Berkowitz A
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 147 011 IHC

Enhancing neuronal chloride extrusion rescues α2/α3 GABAA-mediated analgesia in neuropathic pain.
Lorenzo LE, Godin AG, Ferrini F, Bachand K, Plasencia-Fernandez I, Labrecque S, Girard AA, Boudreau D, Kianicka I, Gagnon M, Doyon N, et al.
Nature communications (2020) 111: 869. 147 011 IHC; tested species: rat

Semaphorin4D Induces Inhibitory Synapse Formation by Rapid Stabilization of Presynaptic Boutons via MET Coactivation.
Frias CP, Liang J, Bresser T, Scheefhals L, van Kesteren M, van Dorland R, Hu HY, Bodzeta A, van Bergen En Henegouwen PMP, Hoogenraad CC, Wierenga CJ, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) 3922: 4221-4237. 147 011 IHC; tested species: mouse

Neurexophilin4 is a selectively expressed α-neurexin ligand that modulates specific cerebellar synapses and motor functions.
Meng X, McGraw CM, Wang W, Jing J, Yeh SY, Wang L, Lopez J, Brown AM, Lin T, Chen W, Xue M, et al.
eLife (2019) 8: . 147 011 IHC; tested species: mouse

Axo-axonic Innervation of Neocortical Pyramidal Neurons by GABAergic Chandelier Cells Requires AnkyrinG-Associated L1CAM.
Tai Y, Gallo NB, Wang M, Yu JR, Van Aelst L
Neuron (2019) : . 147 011 IHC; tested species: mouse

Early postnatal development of pyramidal neurons across layers of the mouse medial prefrontal cortex.
Kroon T, van Hugte E, van Linge L, Mansvelder HD, Meredith RM
Scientific reports (2019) 91: 5037. 147 011 IHC; tested species: mouse

Endocannabinoid Signaling Mediates Local Dendritic Coordination between Excitatory and Inhibitory Synapses.
Hu HY, Kruijssen DLH, Frias CP, Rózsa B, Hoogenraad CC, Wierenga CJ
Cell reports (2019) 273: 666-675.e5. 147 011 IHC; tested species: mouse

Dysregulated protocadherin-pathway activity as an intrinsic defect in induced pluripotent stem cell-derived cortical interneurons from subjects with schizophrenia.
Shao Z, Noh H, Bin Kim W, Ni P, Nguyen C, Cote SE, Noyes E, Zhao J, Parsons T, Park JM, Zheng K, et al.
Nature neuroscience (2019) : . 147 011 IHC; tested species: human,mouse

Early alterations in hippocampal perisomatic GABAergic synapses and network oscillations in a mouse model of Alzheimer's disease amyloidosis.
Hollnagel JO, Elzoheiry S, Gorgas K, Kins S, Beretta CA, Kirsch J, Kuhse J, Kann O, Kiss E
PloS one (2019) 141: e0209228. 147 011 IHC; tested species: mouse

Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch.
Acton D, Ren X, Di Costanzo S, Dalet A, Bourane S, Bertocchi I, Eva C, Goulding M
Cell reports (2019) 283: 625-639.e6. 147 011 IHC; tested species: mouse

Long-Lasting Rescue of Network and Cognitive Dysfunction in a Genetic Schizophrenia Model.
Mukherjee A, Carvalho F, Eliez S, Caroni P
Cell (2019) 1786: 1387-1402.e14. 147 011 IHC; tested species: mouse

Disturbed prefrontal cortex activity in the absence of schizophrenia-like behavioral dysfunction in Arc/Arg3.1 deficient mice.
Gao X, Grendel J, Muhia M, Castro-Gomez S, Süsens U, Isbrandt D, Kneussel M, Kuhl D, Ohana O
The Journal of neuroscience : the official journal of the Society for Neuroscience (2019) : . 147 011 IHC; tested species: mouse

Trans-Synaptic Signaling through the Glutamate Receptor Delta-1 Mediates Inhibitory Synapse Formation in Cortical Pyramidal Neurons.
Fossati M, Assendorp N, Gemin O, Colasse S, Dingli F, Arras G, Loew D, Charrier C
Neuron (2019) : . 147 011 IHC; tested species: mouse

Rbfox1 Mediates Cell-type-Specific Splicing in Cortical Interneurons.
Wamsley B, Jaglin XH, Favuzzi E, Quattrocolo G, Nigro MJ, Yusuf N, Khodadadi-Jamayran A, Rudy B, Fishell G
Neuron (2018) : . 147 011 IHC; tested species: mouse

Developmental pattern and structural factors of dendritic survival in cerebellar granule cells in vivo.
Dhar M, Hantman AW, Nishiyama H
Scientific reports (2018) 81: 17561. 147 011 IHC; tested species: mouse

Long-lasting effects of early-life intervention in mice on adulthood behaviour, GABAA receptor subunit expression and synaptic clustering.
Skilbeck KJ, Johnston GAR, Hinton T
Pharmacological research (2018) 128: 179-189. 147 011 IHC; tested species: mouse

GABAergic deficits and schizophrenia-like behaviors in a mouse model carrying patient-derived neuroligin-2 R215H mutation.
Jiang DY, Wu Z, Forsyth CT, Hu Y, Yee SP, Chen G
Molecular brain (2018) 111: 31. 147 011 IHC; tested species: mouse

Postsynaptic FMRP regulates synaptogenesis in vivo in the developing cochlear nucleus.
Wang X, Zorio DAR, Schecterson L, Lu Y, Wang Y
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) : . 147 011 IHC; tested species: chicken

Neonatal Tbr1 Dosage Controls Cortical Layer 6 Connectivity.
Fazel Darbandi S, Robinson Schwartz SE, Qi Q, Catta-Preta R, Pai EL, Mandell JD, Everitt A, Rubin A, Krasnoff RA, Katzman S, Tastad D, et al.
Neuron (2018) 1004: 831-845.e7. 147 011 IHC; tested species: mouse

Regulation of Synapse Development by Vgat Deletion from ErbB4-Positive Interneurons.
Lin TW, Tan Z, Barik A, Yin DM, Brudvik E, Wang H, Xiong WC, Mei L
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3810: 2533-2550. 147 011 IHC; tested species: mouse

Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican.
Favuzzi E, Marques-Smith A, Deogracias R, Winterflood CM, Sánchez-Aguilera A, Mantoan L, Maeso P, Fernandes C, Ewers H, Rico B
Neuron (2017) 953: 639-655.e10. 147 011 IHC; tested species: mouse

Iterative expansion microscopy.
Chang JB, Chen F, Yoon YG, Jung EE, Babcock H, Kang JS, Asano S, Suk HJ, Pak N, Tillberg PW, Wassie AT, et al.
Nature methods (2017) 146: 593-599. 147 011 IHC; tested species: mouse

Differential role of GABAA receptors and neuroligin 2 for perisomatic GABAergic synapse formation in the hippocampus.
Panzanelli P, Früh S, Fritschy JM
Brain structure & function (2017) 2229: 4149-4161. 147 011 IHC; tested species: mouse

The excitatory/inhibitory input to orexin/hypocretin neuron soma undergoes day/night reorganization.
Laperchia C, Imperatore R, Azeez IA, Del Gallo F, Bertini G, Grassi-Zucconi G, Cristino L, Bentivoglio M
Brain structure & function (2017) 2228: 3847-3859. 147 011 IHC; tested species: mouse

Disinhibition of somatostatin-positive GABAergic interneurons results in an anxiolytic and antidepressant-like brain state.
Fuchs T, Jefferson SJ, Hooper A, Yee PH, Maguire J, Luscher B
Molecular psychiatry (2017) 226: 920-930. 147 011 IHC

Synaptic distribution of individually labeled mitral cells in the external plexiform layer of the mouse olfactory bulb.
Matsuno T, Kiyokage E, Toida K
The Journal of comparative neurology (2017) 5257: 1633-1648. 147 011 IHC; tested species: mouse

Recurrent Inhibition to the Medial Nucleus of the Trapezoid Body in the Mongolian Gerbil (Meriones Unguiculatus).
Dondzillo A, Thompson JA, Klug A
PloS one (2016) 118: e0160241. 147 011 IHC

Enrichment of GABAA Receptor α-Subunits on the Axonal Initial Segment Shows Regional Differences.
Gao Y, Heldt SA
Frontiers in cellular neuroscience (2016) 10: 39. 147 011 IHC

Interneuron- and GABA(A) receptor-specific inhibitory synaptic plasticity in cerebellar Purkinje cells.
He Q, Duguid I, Clark B, Panzanelli P, Patel B, Thomas P, Fritschy JM, Smart TG
Nature communications (2015) 6: 7364. 147 011 IHC

Dendrodendritic synapses in the mouse olfactory bulb external plexiform layer.
Bartel DL, Rela L, Hsieh L, Greer CA
The Journal of comparative neurology (2015) 5238: 1145-61. 147 011 IHC

Postsynaptic gephyrin clustering controls the development of adult-born granule cells in the olfactory bulb.
Deprez F, Pallotto M, Vogt F, Grabiec M, Virtanen MA, Tyagarajan SK, Panzanelli P, Fritschy JM
The Journal of comparative neurology (2015) 52313: 1998-2016. 147 011 IHC, EM

Gephyrin clusters are absent from small diameter primary afferent terminals despite the presence of GABA(A) receptors.
Lorenzo LE, Godin AG, Wang F, St-Louis M, Carbonetto S, Wiseman PW, Ribeiro-da-Silva A, De Koninck Y
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3424: 8300-17. 147 011 IHC; tested species: rat

A unique ion channel clustering domain on the axon initial segment of mammalian neurons.
King AN, Manning CF, Trimmer JS
The Journal of comparative neurology (2014) 52211: 2594-608. 147 011 IHC; tested species: rat

Spatial relationships between GABAergic and glutamatergic synapses on the dendrites of distinct types of mouse retinal ganglion cells across development.
Bleckert A, Parker ED, Kang Y, Pancaroglu R, Soto F, Lewis R, Craig AM, Wong RO
PloS one (2013) 87: e69612. 147 011 IHC; tested species: mouse

Distribution of gephyrin-immunoreactivity in the trigeminal motor nucleus: an immunohistochemical study in rats.
Li Z, Ge S, Zhang F, Zhang T, Mizuno N, Hioki H, Kaneko T, Gao G, Li J
Anatomical record (Hoboken, N.J. : 2007) (2012) 2954: 641-51. 147 011 IHC, EM; tested species: rat

Differential distribution of glycine receptor subtypes at the rat calyx of Held synapse.
Hruskova B, Trojanova J, Kulik A, Kralikova M, Pysanenko K, Bures Z, Syka J, Trussell LO, Turecek R
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 3247: 17012-24. 147 011 IHC, EM

Somatostatin varicosities contain the vesicular GABA transporter and contact orexin neurons in the hypothalamus.
Toossi H, Del Cid-Pellitero E, Stroh T, Jones BE
The European journal of neuroscience (2012) 3610: 3388-95. 147 011 IHC

Distinct mechanisms regulate GABAA receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells.
Panzanelli P, Gunn BG, Schlatter MC, Benke D, Tyagarajan SK, Scheiffele P, Belelli D, Lambert JJ, Rudolph U, Fritschy JM
The Journal of physiology (2011) 589Pt 20: 4959-80. 147 011 IHC, EM; tested species: mouse

Quantitative study of NPY-expressing GABAergic neurons and axons in rat spinal dorsal horn.
Polgár E, Sardella TC, Watanabe M, Todd AJ
The Journal of comparative neurology (2011) 5196: 1007-23. 147 011 IHC; tested species: rat

Mixed GABA-glycine synapses delineate a specific topography in the nucleus tractus solitarii of adult rat.
Dufour A, Tell F, Kessler JP, Baude A
The Journal of physiology (2010) 588Pt 7: 1097-115. 147 011 IHC; tested species: rat

Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome.
Belichenko PV, Kleschevnikov AM, Masliah E, Wu C, Takimoto-Kimura R, Salehi A, Mobley WC
The Journal of comparative neurology (2009) 5124: 453-66. 147 011 IHC; tested species: mouse

Developmental maturation of synaptic and extrasynaptic GABAA receptors in mouse thalamic ventrobasal neurones.
Peden DR, Petitjean CM, Herd MB, Durakoglugil MS, Rosahl TW, Wafford K, Homanics GE, Belelli D, Fritschy JM, Lambert JJ
The Journal of physiology (2008) 5864: 965-87. 147 011 IHC; tested species: mouse

Compensatory alteration of inhibitory synaptic circuits in cerebellum and thalamus of gamma-aminobutyric acid type A receptor alpha1 subunit knockout mice.
Kralic JE, Sidler C, Parpan F, Homanics GE, Morrow AL, Fritschy JM
The Journal of comparative neurology (2006) 4954: 408-21. 147 011 IHC

Synaptic destabilization by neuronal Nogo-A.
Aloy EM, Weinmann O, Pot C, Kasper H, Dodd DA, Rülicke T, Rossi F, Schwab ME
Brain cell biology (2006) 352-3: 137-56. 147 011 IHC

Cerebellar synaptic defects and abnormal motor behavior in mice lacking alpha- and beta-dystrobrevin.
Grady RM, Wozniak DF, Ohlemiller KK, Sanes JR
The Journal of neuroscience : the official journal of the Society for Neuroscience (2006) 2611: 2841-51. 147 011 IHC

Immunofluorescence in brain sections: simultaneous detection of presynaptic and postsynaptic proteins in identified neurons.
Schneider Gasser EM, Straub CJ, Panzanelli P, Weinmann O, Sassoè-Pognetto M, Fritschy JM
Nature protocols (2006) 14: 1887-97. 147 011 IHC

Neurochemical anatomy of the zebrafish retina as determined by immunocytochemistry.
Yazulla S, Studholme KM
Journal of neurocytology (2001) 307: 551-92. 147 011 IHC; tested species: zebrafish

Glycinergic miniature synaptic currents and receptor cluster sizes differ between spinal cord interneurons.
Oleskevich S, Alvarez FJ, Walmsley B
Journal of neurophysiology (1999) 821: 312-9. 147 011 IHC

Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity.
Feng G, Tintrup H, Kirsch J, Nichol MC, Kuhse J, Betz H, Sanes JR
Science (New York, N.Y.) (1998) 2825392: 1321-4. 147 011 IHC; KO verified; tested species: mouse

Dexamethasone binding sites and steroid-dependent stimulation of glycogenesis by insulin in cultured fetal hepatocytes.
Plas C, Duval D
Endocrinology (1986) 1182: 587-94. 147 011 IHC; tested species: mouse

Glioma epileptiform activity and progression are driven by IGSF3-mediated potassium dysregulation.
Curry RN, Aiba I, Meyer J, Lozzi B, Ko Y, McDonald MF, Rosenbaum A, Cervantes A, Huang-Hobbs E, Cocito C, Greenfield JP, et al.
Neuron (2023) : . 147 011 IHC-P; tested species: mouse

Analyzing schizophrenia-related phenotypes in mice caused by autoantibodies against NRXN1α in schizophrenia.
Shiwaku H, Katayama S, Gao M, Kondo K, Nakano Y, Motokawa Y, Toyoda S, Yoshida F, Hori H, Kubota T, Ishikawa K, et al.
Brain, behavior, and immunity (2023) 111: 32-45. 147 011 IHC-P; tested species: mouse

Contribution of the astrocytic tau pathology to synapse loss in progressive supranuclear palsy and corticobasal degeneration.
Briel N, Pratsch K, Roeber S, Arzberger T, Herms J
Brain pathology (Zurich, Switzerland) (2021) 314: e12914. 147 011 IHC-P; tested species: human

PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis.
Yu K, Lin CJ, Hatcher A, Lozzi B, Kong K, Huang-Hobbs E, Cheng YT, Beechar VB, Zhu W, Zhang Y, Chen F, et al.
Nature (2020) : . 147 011 IHC-P; tested species: mouse

Protecting RNA quality for spatial transcriptomics while improving immunofluorescent staining quality.
Hahn N, Bens M, Kempfer M, Reißig C, Schmidl L, Geis C
Frontiers in neuroscience (2023) 17: 1198154. 147 011 IHC-Fr; tested species: mouse

Spatial proteomics in neurons at single-protein resolution.
Unterauer EM, Shetab Boushehri S, Jevdokimenko K, Masullo LA, Ganji M, Sograte-Idrissi S, Kowalewski R, Strauss S, Reinhardt SCM, Perovic A, Marr C, et al.
Cell (2024) 1877: 1785-1800.e16. 147 011 DNA-PAINT; tested species: rat

CLARITY increases sensitivity and specificity of fluorescence immunostaining in long-term archived human brain tissue.
Woelfle S, Deshpande D, Feldengut S, Braak H, Del Tredici K, Roselli F, Deisseroth K, Michaelis J, Boeckers TM, Schön M
BMC biology (2023) 211: 113. 147 011 Clarity; tested species: human

Synaptic reorganization in the adult rat's ventral cochlear nucleus following its total sensory deafferentation.
Hildebrandt H, Hoffmann NA, Illing RB
PloS one (2011) 68: e23686. 147 011 EM; tested species: rat

Monoclonal antibodies and peptide mapping reveal structural similarities between the subunits of the glycine receptor of rat spinal cord.
Pfeiffer F, Simler R, Grenningloh G, Betz H
Proceedings of the National Academy of Sciences of the United States of America (1984) 8122: 7224-7. 147 011

Cat. No.: 147 011

Amount: 100 µg

Price: $435.00

An optimized CRISPR/Cas9 approach for precise genome editing in neurons.
Fang H, Bygrave AM, Roth RH, Johnson RC, Huganir RL
eLife (2021) 10: . 147 011 ICC; tested species: mouse

Activity- and sleep-dependent regulation of tonic inhibition by Shisa7.
Wu K, Han W, Tian Q, Li Y, Lu W
Cell reports (2021) 3412: 108899. 147 011 ICC; tested species: mouse

SNX27-Mediated Recycling of Neuroligin-2 Regulates Inhibitory Signaling.
Halff EF, Szulc BR, Lesept F, Kittler JT
Cell reports (2019) 299: 2599-2607.e6. 147 011 ICC; tested species: rat

Regulation of dendrite morphology and excitatory synapse formation by zDHHC15.
Shah BS, Shimell JJ, Bamji SX
Journal of cell science (2019) 13213: . 147 011 ICC; tested species: rat

Prions activate a p38 MAPK synaptotoxic signaling pathway.
Fang C, Wu B, Le NTT, Imberdis T, Mercer RCC, Harris DA
PLoS pathogens (2018) 149: e1007283. 147 011 ICC; tested species: mouse

GARLH Family Proteins Stabilize GABAA Receptors at Synapses.
Yamasaki T, Hoyos-Ramirez E, Martenson JS, Morimoto-Tomita M, Tomita S
Neuron (2017) 935: 1138-1152.e6. 147 011 ICC

Activity-regulated trafficking of the palmitoyl-acyl transferase DHHC5.
Brigidi GS, Santyr B, Shimell J, Jovellar B, Bamji SX
Nature communications (2015) 6: 8200. 147 011 ICC

Tracing synaptic connectivity onto embryonic stem cell-derived neurons.
Garcia I, Huang L, Ung K, Arenkiel BR
Stem cells (Dayton, Ohio) (2012) 3010: 2140-51. 147 011 ICC; tested species: mouse

Activity-dependent regulation of inhibitory synaptic transmission in hippocampal neurons.
Hartman KN, Pal SK, Burrone J, Murthy VN
Nature neuroscience (2006) 95: 642-9. 147 011 ICC

Recurrent Inhibition to the Medial Nucleus of the Trapezoid Body in the Mongolian Gerbil (Meriones Unguiculatus).
Dondzillo A, Thompson JA, Klug A
PloS one (2016) 118: e0160241. 147 011 IHC

Enrichment of GABAA Receptor α-Subunits on the Axonal Initial Segment Shows Regional Differences.
Gao Y, Heldt SA
Frontiers in cellular neuroscience (2016) 10: 39. 147 011 IHC

Dendrodendritic synapses in the mouse olfactory bulb external plexiform layer.
Bartel DL, Rela L, Hsieh L, Greer CA
The Journal of comparative neurology (2015) 5238: 1145-61. 147 011 IHC

Synaptic destabilization by neuronal Nogo-A.
Aloy EM, Weinmann O, Pot C, Kasper H, Dodd DA, Rülicke T, Rossi F, Schwab ME
Brain cell biology (2006) 352-3: 137-56. 147 011 IHC

Neurochemical anatomy of the zebrafish retina as determined by immunocytochemistry.
Yazulla S, Studholme KM
Journal of neurocytology (2001) 307: 551-92. 147 011 IHC; tested species: zebrafish

ICC

IHC

ExM

Background

Gephyrin is a bifunctional protein which is essential for both synaptic clustering of inhibitory neurotransmitter receptors in the central nervous system and the biosynthesis of the molybdenum cofactor (MoCo) in peripheral tissues. It co-purifies with the inhibitory glycine receptor (GlyR) and is expressed abundantly in all brain areas which contain synapses.

1 ) Hermann A, Biochemical and biophysical research communications (2001) 2821: 67-70.
2 ) Kirsch J, Brain research (1993) 6212: 301-10.
3 ) Kirsch J, The European journal of neuroscience (1993) 59: 1109-17.

Protocols

ICC

IHC

Other products for this target

Gephyrin antibody - 147 011 K.O.

References for Gephyrin - 147 011