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Gephyrin antibody - 147 004

Gephyrin is a scaffolding protein associated with inhibitory neurotransmitter receptors
Guinea pig polyclonal antiserum
Cat. No.: 147 004
Amount: 100 µl
Price: $365.00
Cat. No. 147 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 up to 1 : 5000 (AP staining) gallery  
IP: not tested yet
ICC: not recommended
IHC: not recommended
IHC-P: not tested yet
Immunogen Recombinant protein corresponding to AA 326 to 768 from rat Gephyrin (UniProt Id: Q03555)
Reactivity Reacts with: rat (Q03555), mouse (Q8BUV3).
Other species not tested yet.
Matching control protein/peptide 147-1P
Remarks

This antibody gives better results in WB than the rabbit antibody.

Data sheet 147_004.pdf

References for Gephyrin - 147 004

Molecular layer interneurons shape the spike activity of cerebellar Purkinje cells.
Brown AM, Arancillo M, Lin T, Catt DR, Zhou J, Lackey EP, Stay TL, Zuo Z, White JJ, Sillitoe RV
Scientific reports (2019) 91: 1742. 147 004 IHC-P; tested species: mouse
Cat. No.: 147 004
Amount: 100 µl
Price: $365.00
Molecular layer interneurons shape the spike activity of cerebellar Purkinje cells.
Brown AM, Arancillo M, Lin T, Catt DR, Zhou J, Lackey EP, Stay TL, Zuo Z, White JJ, Sillitoe RV
Scientific reports (2019) 91: 1742. 147 004 IHC-P; tested species: mouse
Background

Gephyrin is a bifunctional protein which is essential for both synaptic clustering of inhibitory neurotransmitter receptors in the central nervous system and the biosynthesis of the molybdenum cofactor (MoCo) in peripheral tissues. It co-purifies with the inhibitory glycine receptor (GlyR) and is expressed abundantly in all brain areas which contain synapses.