Cat. No.: 271 111
Amount: 100 µg
Price:
$415.00
|
|
|
| Cat. No. 271 111 |
100 µg purified IgG, lyophilized. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Clone | 101.1 |
| Subtype | IgG1 (κ light chain) |
| Immunogen | Recombinant protein corresponding to AA 1 to 355 from rat GαO2 (UniProt Id: P18872) |
| Reactivity |
Reacts with: rat (P59215), mouse (P18872), zebrafish. Other species not tested yet. |
| Specificity | Recognizes GαO 1 and GαO 2. K.O. validated PubMed: 15872115 |
| Data sheet | 271_111.pdf |
|
|
Neurotransmitters like monoamines, acetylcholine, glutamate, GABA, and glycine, are loaded into synaptic vesicles by transmitter specific vesicular transporters.
It has been shown that the monoamine transporters VmaT 1 and VmaT 2 are under negative regulation by different α subunits of trimeric G-proteins.
In contrast, the vesicular glutamate transporters (VGLUTs) are exclusively regulated by GαO 2 which modulates the chloride dependence of these proteins.