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Home > Products > 359 004

CAML antibody - 359 004 K.O.

CAML is a receptor for TRC40/Asna1-mediated insertion of tail-anchored proteins
Guinea pig polyclonal antiserum
Cat. No.: 359 004
Amount: 100 µl
Price: $365.00
Cat. No. 359 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: not tested yet
IHC: not tested yet
IHC-P: not tested yet
Immunogen Recombinant protein corresponding to AA 1 to 187 from mouse CAML (UniProt Id: P49070)
Reactivity Reacts with: rat (Q6DGG9), mouse (P49070).
Other species not tested yet.
Specificity K.O. validated PubMed: 36055406
Data sheet 359_004.pdf

References for CAML - 359 004

The GET insertase exhibits conformational plasticity and induces membrane thinning.
McDowell MA, Heimes M, Enkavi G, Farkas Á, Saar D, Wild K, Schwappach B, Vattulainen I, Sinning I
Nature communications (2023) 141: 7355. 359 004 WB
ER entry pathway and glycosylation of GPI-anchored proteins are determined by N-terminal signal sequence and C-terminal GPI-attachment sequence.
Hirata T, Yang J, Tomida S, Tokoro Y, Kinoshita T, Fujita M, Kizuka Y
The Journal of biological chemistry (2022) : 102444. 359 004 WB; KO verified; tested species: human
A trap mutant reveals the physiological client spectrum of TRC40.
Coy-Vergara J, Rivera-Monroy J, Urlaub H, Lenz C, Schwappach B
Journal of cell science (2019) 13213: . 359 004 WB; tested species: human
Cat. No.: 359 004
Amount: 100 µl
Price: $365.00
The GET insertase exhibits conformational plasticity and induces membrane thinning.
McDowell MA, Heimes M, Enkavi G, Farkas Á, Saar D, Wild K, Schwappach B, Vattulainen I, Sinning I
Nature communications (2023) 141: 7355. 359 004 WB
ER entry pathway and glycosylation of GPI-anchored proteins are determined by N-terminal signal sequence and C-terminal GPI-attachment sequence.
Hirata T, Yang J, Tomida S, Tokoro Y, Kinoshita T, Fujita M, Kizuka Y
The Journal of biological chemistry (2022) : 102444. 359 004 WB; KO verified; tested species: human
A trap mutant reveals the physiological client spectrum of TRC40.
Coy-Vergara J, Rivera-Monroy J, Urlaub H, Lenz C, Schwappach B
Journal of cell science (2019) 13213: . 359 004 WB; tested species: human
WB
Background

The integral membrane protein CAML (Calcium signal-modulating cyclophilin ligand) is highly conserved throughout species and constitutively expressed in immune cells and various cells of the nervous system. Besides its link to calcium signaling, it has recently been shown that CAML reconstitutes together with WRB the TRC40 receptor at the endoplasmic reticulum, which mediates post-translationally insertion of tail-anchored membrane proteins into the ER.
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