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Bassoon antibody - 141 016

Bassoon is a large multi-domain protein of the presynaptic active zone
Chicken polyclonal IgY fraction
Cat. No.: 141 016
Amount: 200 µl
Price: $365.00
Cat. No. 141 016 200 µl antibody, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: not recommended
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P: 1 : 500 gallery  
Immunogen Recombinant protein corresponding to residues corresponding to central region rat Bassoon. (UniProt Id: O88778)
Reactivity Reacts with: rat (O88778), mouse (O88737).
Other species not tested yet.
Specificity Specific for bassoon.
Data sheet 141_016.pdf

References for Bassoon - 141 016

Development and Optimization of a Multilayer Rat Purkinje Neuron Culture.
Uggerud IM, Kråkenes T, Hirai H, Vedeler CA, Schubert M
Cerebellum (London, England) (2023) : . 141 016 ICC; tested species: rat
Evolving prion-like tau conformers differentially alter postsynaptic proteins in neurons inoculated with distinct isolates of Alzheimer's disease tau.
Hromadkova L, Kim C, Haldiman T, Peng L, Zhu X, Cohen M, de Silva R, Safar JG
Cell & bioscience (2023) 131: 174. 141 016 ICC; tested species: mouse
A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer's disease.
Jones ME, Büchler J, Dufor T, Palomer E, Teo S, Martin-Flores N, Boroviak K, Metzakopian E, Gibb A, Salinas PC
Science advances (2023) 92: eabo7421. 141 016 ICC, IHC; tested species: mouse
Interaction between Teneurin-2 and microtubules via EB proteins provides a platform for GABAA receptor exocytosis.
Ichinose S, Susuki Y, Hosoi N, Kaneko R, Ebihara M, Hirai H, Iwasaki H
eLife (2023) 12: . 141 016 ICC; tested species: mouse
S-SCAM is essential for synapse formation.
Wittenmayer N, Petkova-Tuffy A, Borgmeyer M, Lee C, Becker J, Böning A, Kügler S, Rhee J, Viotti JS, Dresbach T
Frontiers in cellular neuroscience (2023) 17: 1182493. 141 016 ICC; tested species: rat
Ribosomal RACK1 Regulates the Dendritic Arborization by Repressing FMRP Activity.
Romano N, Di Giacomo B, Nobile V, Borreca A, Willems D, Tilesi F, Catalani E, Agrawal M, Welshhans K, Ricciardi S, Cervia D, et al.
International journal of molecular sciences (2022) 2319: . 141 016 ICC; tested species: mouse
Autism-associated SHANK3 missense point mutations impact conformational fluctuations and protein turnover at synapses.
Bucher M, Niebling S, Han Y, Molodenskiy D, Hassani Nia F, Kreienkamp HJ, Svergun D, Kim E, Kostyukova AS, Kreutz MR, Mikhaylova M, et al.
eLife (2021) 10: . 141 016 ICC; tested species: rat
Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer's disease, restores synapse integrity and memory in a disease mouse model.
Martin Flores N, Podpolny M, McLeod F, Workman I, Crawford K, Ivanov D, Leonenko G, Escott-Price V, Salinas PC
eLife (2024) 12: . 141 016 IHC; tested species: mouse
Mechanisms of simultaneous linear and nonlinear computations at the mammalian cone photoreceptor synapse.
Grabner CP, Futagi D, Shi J, Bindokas V, Kitano K, Schwartz EA, DeVries SH
Nature communications (2023) 141: 3486. 141 016 IHC
Piccolino is required for ribbon architecture at cochlear inner hair cell synapses and for hearing.
Michanski S, Kapoor R, Steyer AM, Möbius W, Früholz I, Ackermann F, Gültas M, Garner CC, Hamra FK, Neef J, Strenzke N, et al.
EMBO reports (2023) 249: e56702. 141 016 IHC; tested species: rat
A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer's disease.
Jones ME, Büchler J, Dufor T, Palomer E, Teo S, Martin-Flores N, Boroviak K, Metzakopian E, Gibb A, Salinas PC
Science advances (2023) 92: eabo7421. 141 016 ICC, IHC; tested species: mouse
Visualizing cellular and tissue ultrastructure using Ten-fold Robust Expansion Microscopy (TREx).
Damstra HGJ, Mohar B, Eddison M, Akhmanova A, Kapitein LC, Tillberg PW
eLife (2022) 11: . 141 016 IHC; tested species: mouse
Selective Enrichment of Munc13-2 in Presynaptic Active Zones of Hippocampal Pyramidal Cells That Innervate mGluR1α Expressing Interneurons.
Holderith N, Aldahabi M, Nusser Z
Frontiers in synaptic neuroscience (2021) 13: 773209. 141 016 IHC; tested species: mouse
A High-Resolution Method for Quantitative Molecular Analysis of Functionally Characterized Individual Synapses.
Holderith N, Heredi J, Kis V, Nusser Z
Cell reports (2020) 324: 107968. 141 016 IHC; tested species: rat
Coherent Activity between the Prelimbic and Auditory Cortex in the Slow-Gamma Band Underlies Fear Discrimination.
Concina G, Cambiaghi M, Renna A, Sacchetti B
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3839: 8313-8328. 141 016 IHC; tested species: rat
Cat. No.: 141 016
Amount: 200 µl
Price: $365.00
Development and Optimization of a Multilayer Rat Purkinje Neuron Culture.
Uggerud IM, Kråkenes T, Hirai H, Vedeler CA, Schubert M
Cerebellum (London, England) (2023) : . 141 016 ICC; tested species: rat
Evolving prion-like tau conformers differentially alter postsynaptic proteins in neurons inoculated with distinct isolates of Alzheimer's disease tau.
Hromadkova L, Kim C, Haldiman T, Peng L, Zhu X, Cohen M, de Silva R, Safar JG
Cell & bioscience (2023) 131: 174. 141 016 ICC; tested species: mouse
A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer's disease.
Jones ME, Büchler J, Dufor T, Palomer E, Teo S, Martin-Flores N, Boroviak K, Metzakopian E, Gibb A, Salinas PC
Science advances (2023) 92: eabo7421. 141 016 ICC, IHC; tested species: mouse
Interaction between Teneurin-2 and microtubules via EB proteins provides a platform for GABAA receptor exocytosis.
Ichinose S, Susuki Y, Hosoi N, Kaneko R, Ebihara M, Hirai H, Iwasaki H
eLife (2023) 12: . 141 016 ICC; tested species: mouse
S-SCAM is essential for synapse formation.
Wittenmayer N, Petkova-Tuffy A, Borgmeyer M, Lee C, Becker J, Böning A, Kügler S, Rhee J, Viotti JS, Dresbach T
Frontiers in cellular neuroscience (2023) 17: 1182493. 141 016 ICC; tested species: rat
Ribosomal RACK1 Regulates the Dendritic Arborization by Repressing FMRP Activity.
Romano N, Di Giacomo B, Nobile V, Borreca A, Willems D, Tilesi F, Catalani E, Agrawal M, Welshhans K, Ricciardi S, Cervia D, et al.
International journal of molecular sciences (2022) 2319: . 141 016 ICC; tested species: mouse
Autism-associated SHANK3 missense point mutations impact conformational fluctuations and protein turnover at synapses.
Bucher M, Niebling S, Han Y, Molodenskiy D, Hassani Nia F, Kreienkamp HJ, Svergun D, Kim E, Kostyukova AS, Kreutz MR, Mikhaylova M, et al.
eLife (2021) 10: . 141 016 ICC; tested species: rat
Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer's disease, restores synapse integrity and memory in a disease mouse model.
Martin Flores N, Podpolny M, McLeod F, Workman I, Crawford K, Ivanov D, Leonenko G, Escott-Price V, Salinas PC
eLife (2024) 12: . 141 016 IHC; tested species: mouse
Mechanisms of simultaneous linear and nonlinear computations at the mammalian cone photoreceptor synapse.
Grabner CP, Futagi D, Shi J, Bindokas V, Kitano K, Schwartz EA, DeVries SH
Nature communications (2023) 141: 3486. 141 016 IHC
Piccolino is required for ribbon architecture at cochlear inner hair cell synapses and for hearing.
Michanski S, Kapoor R, Steyer AM, Möbius W, Früholz I, Ackermann F, Gültas M, Garner CC, Hamra FK, Neef J, Strenzke N, et al.
EMBO reports (2023) 249: e56702. 141 016 IHC; tested species: rat
A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer's disease.
Jones ME, Büchler J, Dufor T, Palomer E, Teo S, Martin-Flores N, Boroviak K, Metzakopian E, Gibb A, Salinas PC
Science advances (2023) 92: eabo7421. 141 016 ICC, IHC; tested species: mouse
Visualizing cellular and tissue ultrastructure using Ten-fold Robust Expansion Microscopy (TREx).
Damstra HGJ, Mohar B, Eddison M, Akhmanova A, Kapitein LC, Tillberg PW
eLife (2022) 11: . 141 016 IHC; tested species: mouse
Selective Enrichment of Munc13-2 in Presynaptic Active Zones of Hippocampal Pyramidal Cells That Innervate mGluR1α Expressing Interneurons.
Holderith N, Aldahabi M, Nusser Z
Frontiers in synaptic neuroscience (2021) 13: 773209. 141 016 IHC; tested species: mouse
A High-Resolution Method for Quantitative Molecular Analysis of Functionally Characterized Individual Synapses.
Holderith N, Heredi J, Kis V, Nusser Z
Cell reports (2020) 324: 107968. 141 016 IHC; tested species: rat
Coherent Activity between the Prelimbic and Auditory Cortex in the Slow-Gamma Band Underlies Fear Discrimination.
Concina G, Cambiaghi M, Renna A, Sacchetti B
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 3839: 8313-8328. 141 016 IHC; tested species: rat
Background

Bassoon is a large protein which consists of an N-terminal Zn2+ finger and several piccolo-bassoon homology domains (PBH-domains). It is generally found together with piccolo, a related huge multi-domain protein of the CAZ (cytoskeletal matrix assembled at active zones).
Bassoon was suggested to be a scaffolding element of the presynapse but deletion experiments in mice have shown that bassoon is also involved in synaptic vesicle cycling. Probably bassoon interacts with other protein factors via its Zn2+ domain but the potential partners have not been determined yet.