CLEC4F antibody C-terminal - HS-501 003

The murine CLEC4F is a hallmark of mouse Kupffer cells (KCs) and its expression distinguishes KCs and recruited macrophages (1). CLEC4F is a C-type lectin participating in the antigen presentation of glycolipid antigens, as well as in the recognition and scavenging of desialylated platelets (2). The human CLEC4F gene does not encode a functional receptor due to a mutation in the splice acceptor site of the final exon preventing the appropriate splicing and a missense mutation disrupts the sugar-binding site (3). CLEC4F colocalises with F4/80. Although F4/80 is constitutively expressed in peripheral and resident macrophages, CLEC4F is inducible in the liver and its expression appears when primitive macrophages migrate into the fetal liver. Moreover, CLEC4F and F4/80 cells in the liver increase after infection (4).