iNOS antibody mouse specific - HS-484 017

Inducible nitric oxide synthase (iNOS) belongs together with endothelial NOS (eNOS) and neuronal NOS (nNOS) to the NOS family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. In contrast to the constitutively expressed calcium-dependent eNOS and nNOS isoforms, iNOS is calcium-independent and usually activated in defense responses such as infection and inflammation (1). Expression of the iNOS gene is induced in vitro in macrophages polarized to the pro-inflammatory M1 state (2). NO-producing tumoricidal macrophages in the tumor microenvironment can modulate immune responses and promote apoptosis of tumor cells (2). In the brain, iNOS is normally not expressed except in chronic and acute inflammatory conditions. In ischemic brain injury, iNOS was found to be highly expressed in neutrophils and endothelium (3) and in M1-like pro-inflammatory microglia (4).