JAM-A antibody - 522 004

Junctional adhesion molecule-A (JAM-A) is a key transmembrane protein in cell adhesion, immune response, and barrier integrity. It localizes at tight junctions, interacting with ZO-1 and PAR-3 to regulate cell polarity and maintain the blood-brain barrier (BBB) (1). JAM-A also facilitates leukocyte adhesion and transmigration, crucial for immune defense but implicated in inflammatory diseases (1). In the BBB, its downregulation correlates with barrier breakdown in conditions like multiple sclerosis (2). Overexpression in glioblastomas links JAM-A to tumor stem cell maintenance and therapy resistance (3). As a therapeutic target, JAM-A inhibition can reduce leukocyte infiltration and tissue damage, with implications for inflammatory bowel disease, stroke, and cancer (1). Its dual role in junction stabilization and disease progression makes JAM-A a key focus for medical research. JAM-A has a molecular weight of 29 kD which can reach between 32 kD and 43 kD as a result of post-translational modifications (N-glycosylation) or due to differences in mRNA splicing (4).

• AP Detection
• ECL Detection
• Fluorescent detection
• Pre-adsorption protocol

• PFA fixation
• Glyoxal fixation
• Pre-adsorption protocol