Cat. No.: 520 017
Amount: 100 µg
Price:
$415.00
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| Cat. No. 520 017 |
100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Clone | SY-256H3 |
| Subtype | IgG2a (κ light chain) |
| Immunogen | Full-length recombinant mouse c-Jun (UniProt Id: P05627) |
| Reactivity |
Reacts with: mouse (P05627), rat (P17325). Other species not tested yet. |
| Remarks |
IHC: This antibody produces some filamentous background on rat brain. |
| Data sheet | 520_017.pdf |
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Like c-Fos, c-Jun is a key member of the activator protein-1 (AP-1) transcription factor complex and plays an important role in many cellular activities including proliferation, apoptosis, survival, and differentiation (1). As part of the bZIP family, it can form homo- and heterodimers, which initiate specific gene transcription (2, 3).
c-Jun mediates transcriptional responses to various signals, such as growth factors, stress stimuli, and oncogenes in many cell types and tissues (1, 3). In embryonic tissues, c-Jun expression is abundant (1). However, this changes in adult tissues, where it is primarily expressed in actively dividing neural precursor cells (4). The complex interplay of structure, function, and expression profiles makes c-Jun a significant target for research in neuroscience, developmental biology, and cancer (5).