Cat. No.: 509 005
Amount: 50 µg
Price:
$460.00
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| Cat. No. 509 005 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Synthetic peptide corresponding to residues near the carboxy terminus of mouse Prox1 (UniProt Id: P48437) |
| Reactivity |
Reacts with: mouse (P48437), rat (D3ZU00). Other species not tested yet. |
| Data sheet | 509_005.pdf |
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The prospero-related homeobox transcription factor 1, Prox1, is important for the embryonic development of various organs (1) including the eye, liver, pancreas, lymphatic system, heart and the central nervous system (CNS) (2). It is a regulator of cell division with impact on e.g. neurogenesis and cancer development and progression. In the CNS, the expression is not restricted to the embryonic development and to precursor cells. Prox1 is a well-known marker for granule cells of the dentate gyrus (DG) during embryonic development, adult neurogenesis but also for mature granule cells in the adult brain (3). Weaker expression can also be detected outside the DG of the adult brain. Prox1 was shown to be expressed in oligodendrocyte progenitors, e.g. in the subventricular zone and the corpus callosum (4) and in a subtype of cortical interneurons (5).