Cat. No.: 502 005
Amount: 50 µg
Price:
$460.00
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| Cat. No. 502 005 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications |
ICC: not recommended IHC: not recommended IHC-P: not tested yet |
| Immunogen | Full length recombinant mouse PICK1 (UniProt Id: Q62083) |
| Reactivity |
Reacts with: mouse (Q62083), rat (Q9EP80). Other species not tested yet. |
| Data sheet | 502_005.pdf |
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PICK1 (protein interacts with c-kinase1) is a peripheral membrane protein that regulates the trafficking of pre- and postsynaptic neurotransmitter receptors (1, 2). PICK1 contains a PDZ domain that interacts with the carboxy termini of different receptor proteins (2) and a BAR domain, that mediates the lipid membrane interaction (3).
Via interaction with the endocytic proteins AP2 and Dynamin, PICK1 is involved in the clathrin mediated endocytosis of GluA2 containing AMPA receptors in response to NMDA receptor stimulation (4).