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APLP1 antibody - 489 011 K.O.

APLP1, a protein of the highly conserved amyloid precursor protein family
Mouse monoclonal purified IgG
Cat. No.: 489 011
Amount: 100 µg
Price: $415.00
Cat. No. 489 011 100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
WB: 1 : 1000 (AP-Staining) gallery  
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: not tested yet
IHC-P: 1 : 1000 gallery  
Clone SY-344A12
Subtype IgG2c (κ light chain)
Immunogen Synthetic peptide corresponding to residues near the carboxy terminus of mouse APLP1 (UniProt Id: Q03157)
Reactivity Reacts with: mouse (Q03157), rat (B1WBV6).
Other species not tested yet.
Specificity K.O. validated
Data sheet 489_011.pdf
Cat. No.: 489 011
Amount: 100 µg
Price: $415.00

Amyloid beta precursor like protein 1 and 2 (APLP1 and 2) and amyloid precursor protein (APP) belong to one protein family that all share considerable sequence homolgy in the amino- and carboxyl termini (1, 2). In contrast to APP, APLP1 and 2 do not contain the Abeta motif. Like APP, APLP1 and 2 are processed by alpha-, beta-, and gamma-secretase leading to a secreted ecto-domain and a membrane-anchored C-terminal fragment (3). APLPs function as synaptic adhesion molecules (SAMs) and are involved in synaptogenesis (4).
In contrast to the ubiquitously expressed APLP2, APLP1 selectively occurs in neuronal cells and has been shown to accumulate in neuritic plaques during Alzheimer’s disease(4, 5).