|Cat. No. 489 011||
100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Immunoprecipitation (IP); Immunoisolation or pulldown of a target molecule using an antibody. For details and product specific hints, please refer to the ”Remarks” section.', $event)" style="cursor: help;">IP: not tested yet
Immunocytochemistry (ICC) on 4% PFA fixed cells. Immunoreactivity is usually revealed by fluorescence. Some antibodies require special fixation methods. For details, please refer to the “Remarks” section.', $event)" style="cursor: help;">ICC: 1 : 500 gallery
Immunohistochemistry (IHC) on 4% PFA perfusion fixed tissue with 24h PFA post fixation. Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. Some antibodies require special fixation methods or antigen retrieval steps. For details, please refer to the ”Remarks” section.', $event)" style="cursor: help;">IHC: not tested yet
Immunohistochemistry (IHC-P) of formalin fixed, paraffin embedded (FFPE) tissue (some antibodies require special antigen retrieval steps, please refer to the ”Remarks” section). Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate.', $event)" style="cursor: help;">IHC-P: 1 : 1000 gallery
|Subtype||IgG2c (κ light chain)|
|Immunogen||Synthetic peptide corresponding to residues near the carboxy terminus of mouse APLP1 (UniProt Id: Q03157)|
Reacts with: mouse (Q03157), rat (B1WBV6).
Other species not tested yet.
Amyloid beta precursor like protein 1 and 2 (APLP1 and 2) and amyloid precursor protein (APP) belong to one protein family that all share considerable sequence homolgy in the amino- and carboxyl termini (1, 2). In contrast to APP, APLP1 and 2 do not contain the Abeta motif. Like APP, APLP1 and 2 are processed by alpha-, beta-, and gamma-secretase leading to a secreted ecto-domain and a membrane-anchored C-terminal fragment (3). APLPs function as synaptic adhesion molecules (SAMs) and are involved in synaptogenesis (4).
In contrast to the ubiquitously expressed APLP2, APLP1 selectively occurs in neuronal cells and has been shown to accumulate in neuritic plaques during Alzheimer’s disease(4, 5).