Cat. No.: 486 003
Amount: 50 µg
Price:
$375.00
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| Cat. No. 486 003 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Recombinant protein corresponding to residues near the carboxy terminus from mouse Myosin-11. (UniProt Id: O08638) |
| Reactivity |
Reacts with: human (P35749), mouse (O08638), rat (Q63862). Other species not tested yet. |
| Specificity | Specific for Myosin-11, detect only isoform1. |
| Remarks |
IHC-Fr: methanol fixation is recommended |
| Data sheet | 486_003.pdf |
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Myosin-11 also called smooth muscle myosin heavy chain or SMMHC is a myosin expressed in smooth muscle that functions as a primary contractile protein. Myosin-11 is a common myoepithelial marker in immunohistochemistry, showing cytoplasmic and membranous positivity in myoepithelial and smooth muscle cells. It tends to provide more sensitive results with less myofibroblast cross-reactivity when compared to biomarkers like calponin and smooth muscle actin (1). Four Myosin-11 isoforms exist as a result of alternative splicing of the mRNA product of a single gene (2- 5).