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Home > Products > 483 005

Tbr2 antibody - 483 005

A T-domain transcrition factor involved in brain development
Guinea pig polyclonal purified antibody
Cat. No.: 483 005
Amount: 50 µg
Price: $460.00
Cat. No. 483 005 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: not recommended
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P: not tested yet
Immunogen Recombinant protein corresponding to residues near the carboxy terminus of mouse Tbr2 (UniProt Id: O54839)
Reactivity Reacts with: mouse (O54839), rat (D3ZY52).
Other species not tested yet.
Data sheet 483_005.pdf

References for Tbr2 - 483 005

A single-cell transcriptomic map of the developing Atoh1 lineage identifies neural fate decisions and neuronal diversity in the hindbrain.
Butts JC, Wu SR, Durham MA, Dhindsa RS, Revelli JP, Ljungberg MC, Saulnier O, McLaren ME, Taylor MD, Zoghbi HY
Developmental cell (2024) : . 483 005 IHC; tested species: mouse
Cat. No.: 483 005
Amount: 50 µg
Price: $460.00
A single-cell transcriptomic map of the developing Atoh1 lineage identifies neural fate decisions and neuronal diversity in the hindbrain.
Butts JC, Wu SR, Durham MA, Dhindsa RS, Revelli JP, Ljungberg MC, Saulnier O, McLaren ME, Taylor MD, Zoghbi HY
Developmental cell (2024) : . 483 005 IHC; tested species: mouse
ICC
ICC
IHC
IHC
IHC
IHC
IHC
IHC
Background

Tbr2 also known as Eomesodermin is a T-domain transcription factor playing a crucial role during brain development (1). In the developing neocortex Tbr2 is upregulated during the transition from radial glia to to intermediate progenitor cells (2). Tbr2 disruption has shown its involvement in trophoblast differentiation and later in gastrulation (3). Furthermore, it functions in the differentiation of CD8+ T-cells during immune response (4).