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Neuron-glial antigen 2 antibody - 481 002

The NG2 is a valuable marker for several incompletely differentiated precursor cells.
Rabbit polyclonal antiserum
Cat. No.: 481 002
Amount: 200 µl
Price: $350.00
Cat. No. 481 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 500 up to 1 : 1000 (AP-staining) gallery  
IP: not tested yet
ICC: 1 : 500 (see remarks) gallery  
IHC: not recommended
IHC-P: not recommended
IHC-Fr: not recommended
Immunogen Synthetic peptide mix corresponding to residues near the carboxy and amino terminus of mouse Neuron-glial antigen 2 (UniProt Id: Q8VHY0)
Reactivity Reacts with: mouse (Q8VHY0), rat (Q00657).
Other species not tested yet.
Specificity Specific for Neuron-glial antigen 2
Remarks

Weak unspecific nuclear staining of neurons.
ICC: methanol

Data sheet 481_002.pdf
Cat. No.: 481 002
Amount: 200 µl
Price: $350.00
Background

The NG2 proteoglycan is a type I membrane protein that is expressed by a variety of immature cells of several embryonic tissue origins including glia, muscle progenitor cells, and pericytes (1). In the central nervous system, expression of NG2 was originally thought to specify oligodendroglial progenitor cells, but more recent data suggest that NG2-expressing cells encompass a wider range of immature glial cells in white and gray matter. These include glia that make synaptic-like contacts with neurons in the hippocampus and cerebellum (2) and glial cells specifically associated with the nodes of Ranvier (3). Interestingly, many NG2-positive cells are both proliferative and motile or exhibit local process motility (4, 5).