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PCP4 antibody - 480 004

PCP4 modulates calcium binding by calmodulin
Guinea pig polyclonal antiserum
Cat. No.: 480 004
Amount: 100 µl
Price: $350.00
Cat. No. 480 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: not recommended
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P: 1 : 500 gallery  
Immunogen full length human recombinant PCP4 (UniProt Id: P48539)
Reactivity Reacts with: mouse (P63054), rat (P63055).
Other species not tested yet.
Specificity Specific for PCP4
Data sheet 480_004.pdf
Cat. No.: 480 004
Amount: 100 µl
Price: $350.00
Background

Purkinje-cell protein 4 (PCP4) also known as PEP-19, is a small calmodulin (CaM)-binding protein that exhibits high expression levels in cerebellar Purkinje cells. PCP4 also occurs in neocortical structures, especially in the deep layers, and in other cortical structures and parts of the hippocampus. Furthermore, the olfactory bulb and caudate putamen show high PCP4 levels. (1). PCP4 selectively binds to the C-domain of CaM via an IQ motif (2) and modulates CaM signaling by acting at the level of Ca2+ binding to CaM (3).