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CaBP 5 antibody - 475 003

CaBP5 is retina specific calcium binding protein
Rabbit polyclonal purified antibody
Cat. No.: 475 003
Amount: 50 µg
Price: $450.00
Cat. No. 475 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications
 
WB: 1 : 1000 (AP-staining) gallery  
IP: not tested yet
ICC: not tested yet
IHC: 1 : 500 (see remarks) gallery  
IHC-P: 1 : 1000 gallery  
Immunogen Full length mouse recombinant CaBP 5 (UniProt Id: D3ZW89)
Reactivity Reacts with: mouse (Q9JLK3), rat (D3ZW89).
Other species not tested yet.
Specificity Due to sequence homology, the antibody may exhibit some cross-reactivity to CaBP1, 2, 3 and 4.
Remarks

IHC: Brief immersion fixation of retina samples gives best results. For over night fixed tissues, a heat mediated antigen retrieval (AGR) can be applied.

Data sheet 475_003.pdf
Cat. No.: 475 003
Amount: 50 µg
Price: $450.00
Background

Calcium binding protein 5 (CaBP 5) belongs to a subfamiliy of neuronal Ca2+ binding proteins (CaBP 1-5) that show a high similarity to Calmodulin (1).
It is expressed in rod and cone bipolar cells of the retina (1) and cochlea inner hair cells of the ear (2).
CaBPs are involved in the modulation of voltage gated calcium channels, TRP channels and inositol1,4,5-triphosphate (IP3) receptors (2).
A CaBP 5 K.O. model suggests that this Ca-binding protein is involved in the rod-mediated response across the retina (3).