Cat. No.: 473 005
Amount: 50 µg
Price:
$460.00
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| Cat. No. 473 005 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Recombinant protein corresponding to residues near the carboxy terminus of mouse P-glycoprotein 1. (UniProt Id: P06795) |
| Reactivity |
Reacts with: mouse (P06795), rat (P43245). Other species not tested yet. |
| Remarks |
WB: P-glycoprotein1 aggregates after boiling, making it necessary to run SDS-PAGE with non-boiled samples. |
| Data sheet | 473_005.pdf |
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P-glycoprotein (Pgp) is a member of the ATP-binding cassette (ABC) superfamily of transport proteins that utilize ATP to translocate a variety of lipophilic substrates across biological membranes. (1) Pgp is encoded for by a family of genes referred to as the multidrug resistance or MDR genes [2, 3] whose products function as multidrug efflux pumps [3, 4].
P-glycoprotein (Pgp) is one of the proteins expressed naturally on the plasmatic membranes of endothelial cells at the blood-brain barrier (BBB). It protects the brain from harmful substances by excluding them from entering into the parenchyma from blood circulation. It is one of several so-called efflux pumps present at the BBB and in other organs. Overexpression of this protein excludes a wide range of therapeutics for use as treatment for Central Nervous System (CNS) disorders. (5)