N-acyl amino acids are a group of bioactive lipids with transmitter function (1) that consist of a fatty acid tail conjugated to an amino acid head group (amidated lipids or fatty acid amides). Fatty-acid amide hydrolase 1 (FAAH 1) is an ER associated transmembrane protein (2) that catalyzes the hydrolysis and thereby inactivation of different endogenous amidated lipids to their corresponding fatty acids. Prominent examples are the appetite stimulating endocannabinoid anandamide (3) as well as oleamid, a fatty acid amide involved in sleep regulation (4). Intracellular, membrane located FAAH1 and the extracellular N-acyl amino acid synthase/hydrolase PM20D1 cooperate in the hydrolysis of amino acid-conjugated fatty acids and show overlapping but distinct substrate specificity (2).