Cat. No.: 465 004
Amount: 100 µl
Price:
$365.00
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| Cat. No. 465 004 |
100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Recombinant protein corresponding to AA 19 to 311 from mouse ApoE ms (UniProt Id: P08226) |
| Reactivity |
Reacts with: mouse (P08226), rat (P02650). Other species not tested yet. |
| Specificity | Specific for ApoE K.O. validated |
| Data sheet | 465_004.pdf |
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Apolipoprotein E (ApoE) is one major apolipoprotein of several lipoprotein classes and mediates the cellular uptake of lipoproteins (1). It is not only a central player in lipid metabolism, it also plays a role in neurobiology and has an impact on neurodegenerative diseases like Alzheimer’s disease (2). In contrast to mice, which express only one isoform, the human gene has three major allelic variants (ApoE2, ApoE3, ApoE4) with ApoE4 as one of the strongest genetic risk factors for developing Alzheimer’s disease (3). High levels of ApoE protein are found in liver, brain, kidney or spleen (2). In the central nervous system ApoE is mainly expressed by astrocytes and smooth muscle cells around big vessels (4). Neurons and microglia increase ApoE expression after injury.