|Cat. No. 448 003||50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.|
WB: 1 : 1000 gallery
IP: not tested yet
ICC: 1 : 500 gallery
IHC: 1 : 500 up to 1 : 1000 gallery
IHC-P/FFPE: not tested yet
|Immunogen||Recombinant protein corresponding to AA 629 to 719 from mouse Elfn1 (UniProt Id: Q8C8T7)|
Reacts with: mouse (Q8C8T7), rat (D3ZZ44).
Other species not tested yet.
|Specificity||Specific for ELFN 1|
Extracellular leucine-rich repeat and fibronectin type-III domain-containing protein 1 (ELFN1) is a a postsynaptic protein that regulates circuit dynamics in the central nervous system (1) and is expressed with increasing levels during postnatal development (2).
ELFN1 is involved in the generation of facilitating synapses onto somatostatin interneurons by the recruitment of the two pre-synaptic components mGluR7 and GluK2 (2, 3).
Missense mutations of ELFN1 in the carboxy-terminal region required for mGluR7 recruitment have been observed in patients with epilepsy and attention deficit hyperactivity disorder (ADHD) (2).