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BCAS1 antibody - 445 004

BCAS1 is a protein specific for an actively myelinating oligodendrocyte subpopulation
Guinea pig polyclonal antiserum
Cat. No.: 445 004
Amount: 100 µl
Price: $365.00
Cat. No. 445 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) (see remarks) gallery  
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P: 1 : 1000 gallery  
Immunogen Mixture of two synthetic peptides corresponding to AA 305-327 and AA 360–379 in rat BCAS1 (UniProt Id: Q3ZB98)
Reactivity Reacts with: mouse (Q80YN3), rat (Q3ZB98), human (O75363).
Other species not tested yet.
Specificity Specific for BCAS1 and its known isoforms
Remarks

WB: shows almost no signal in westernblots on mouse brain lysate.

Data sheet 445_004.pdf

References for BCAS1 - 445 004

Age and Alzheimer's Disease-Related Oligodendrocyte Changes in Hippocampal Subregions.
DeFlitch L, Gonzalez-Fernandez E, Crawley I, Kang SH
Frontiers in cellular neuroscience (2022) 16: 847097. 445 004 IHC; tested species: mouse
Cat. No.: 445 004
Amount: 100 µl
Price: $365.00
Age and Alzheimer's Disease-Related Oligodendrocyte Changes in Hippocampal Subregions.
DeFlitch L, Gonzalez-Fernandez E, Crawley I, Kang SH
Frontiers in cellular neuroscience (2022) 16: 847097. 445 004 IHC; tested species: mouse
Background

Breast carcinoma-amplified sequence 1 (BCAS1) was originally identified as a potential oncogene amplified in human cancer cell lines (1). It is also highly expressed in brain (2) where it mainly defines an oligodendroglial subpopulation occuring at regions of active myelin formation (3).
In fetal brain BCAS1 positive oligodendrocytes are restricted to the white matter. In adult brains they persist in the grey matter until old age (3).