|Cat. No. 445 004||100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.|
WB: 1 : 1000 (AP staining) (see remarks) gallery
IP: not tested yet
ICC: 1 : 500 gallery
IHC: 1 : 500 gallery
IHC-P/FFPE: 1 : 1000 gallery
|Immunogen||Mixture of two synthetic peptides corresponding to AA 305-327 and AA 360–379 in rat BCAS1|
Reacts with: mouse (Q80YN3), rat (Q3ZB98).
Other species not tested yet.
|Specificity||Specific for BCAS1 and its isoforms|
WB: shows almost no signal in westernblots on mouse brain lysate.
Breast carcinoma-amplified sequence 1 (BCAS1) was originally identified as a potential oncogene amplified in human cancer cell lines (1). It is also highly expressed in brain (2) where it mainly defines an oligodendroglial subpopulation occuring at regions of active myelin formation (3).
In fetal brain BCAS1 positive oligodendrocytes are restricted to the white matter. In adult brains they persist in the grey matter until old age (3).