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BCAS1 antibody - 445 004

BCAS1 is a protein specific for an actively myelinating oligodendrocyte subpopulation
Guinea pig polyclonal antiserum
Cat. No.: 445 004
Amount: 100 µl
Price: $350.00
Cat. No. 445 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 (AP staining) (see remarks) gallery  
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P/FFPE: 1 : 1000 gallery  
Immunogen Mixture of two synthetic peptides corresponding to AA 305-327 and AA 360–379 in rat BCAS1
Reactivity Reacts with: mouse (Q80YN3), rat (Q3ZB98).
Other species not tested yet.
Specificity Specific for BCAS1 and its isoforms
Remarks

WB: shows almost no signal in westernblots on mouse brain lysate.

Data sheet 445_004.pdf
Cat. No.: 445 004
Quantity: 100 µl
Price: $350.00
Background

Breast carcinoma-amplified sequence 1 (BCAS1) was originally identified as a potential oncogene amplified in human cancer cell lines (1). It is also highly expressed in brain (2) where it mainly defines an oligodendroglial subpopulation occuring at regions of active myelin formation (3).
In fetal brain BCAS1 positive oligodendrocytes are restricted to the white matter. In adult brains they persist in the grey matter until old age (3).