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BCAS1 - 445 003

A protein specific for an actively myelinating oligodendrocyte subpopulation
Polyclonal rabbit purified antibody
Cat. No.: 445 003
Amount: 50 µg
Price: 370.00 €
Cat. No. 445 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 up to 1 : 2000 (AP-staining) gallery  
IP: not tested yet
ICC: 1 : 1000 gallery  
IHC: 1 : 1000 gallery  
IHC-P/FFPE: 1 : 200 up to 1 : 1000 gallery  
Immunogen Recombinant protein corresponding to AA 1 to 226 from mouse BCAS1 (UniProt Id: Q80YN3)
Reactivity Reacts with: mouse (Q80YN3), rat (Q3ZB98-1).
Other species not tested yet.
Specificity BCAS1 and its isoforms
Data sheet 445_003.pdf
Cat. No.: 445 003
Quantity: 50 µg
Price: 370.00 €
Background

Breast carcinoma-amplified sequence 1 (BCAS1) was originally identified as a potential oncogene amplified in human cancer cell lines (1). It is also highly expressed in brain (2) where it mainly defines an oligodendroglial subpopulation occuring at regions of active myelin formation (3).
In fetal brain BCAS1 positive oligodendrocytes are restricted to the white matter. In adult brains they persist in the grey matter until old age (3).