|Cat. No. 444 005||100 µl specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O. Then aliquot and store at -20°C to -80°C until use.|
WB: not recommended
IP: not recommended
ICC: not tested yet
IHC: 1 : 500 (see remarks) gallery
IHC-P/FFPE: not tested yet
|Immunogen||Recombinant protein corresponding to AA 601-629 in mouse TRPV1|
Reacts with: mouse (Q704Y3), rat (O35433).
Other species not tested yet.
|Specificity||Specific for TRPV1|
IHC: Antigen retrieval (10mM citrate, pH 6.0, overnight at 60°C) is recommended.
TRPV1 (Transient receptor potential cation channel subfamily V member 1, also capsaicin receptor and vanilloid receptor 1) is a member of the TRPV group of the transient receptor potential family of ion channels (1, 3). Expression has been mainly reported in sensory neurons of the peripheral and central nervous system (2, 3). The receptor is activated by a wide variety of exogenous and endogenous physical and chemical stimuli like temperature greater than 42°C; acidic conditions (pH<6); vanilloids, like capsaicin, and allyl isothiocyanate (3). In addition to direct activation, TRPV1 channel activity can also be modulated by inflammatory mediators, such as prostaglandins and bradykinin (4). TRPV1 is involved in the detection and regulation of body temperature, as well as in the sensation of noxious environmental stimuli, like scalding heat and pain. TRPV1 acts as ionotropic endocannabinoid receptor with central neuromodulatory effects and is a prime target for the development of analgesics (5).