Home|||||||Technical Support|

TRPV1 extracellular domain - 444 003

a transient potential cation receptor involved in the regulation of body temperature and nociception
Polyclonal rabbit purified antibody
Cat. No.: 444 003
Amount: 50 µg
Price: 370.00 €
Cat. No. 444 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 gallery  
IP: not tested yet
ICC: not tested yet
IHC: 1 : 2000 Antigen retrieval (10mM citrate, pH 6.0, overnight at 60°C) is recommended. gallery  
IHC-P/FFPE: not tested yet
Immunogen Recombinant protein corresponding to AA 601-629 in mouse TRPV1
Reactivity Reacts with: mouse (Q704Y3).
Weaker signal: rat (O35433).
Other species not tested yet.
Specificity specific for TRPV1
Data sheet 444_003.pdf
Cat. No.: 444 003
Quantity: 50 µg
Price: 370.00 €
Background

TRPV1 (Transient receptor potential cation channel subfamily V member 1, also capsaicin receptor and vanilloid receptor 1) is a member of the TRPV group of the transient receptor potential family of ion channels (1, 3). Expression has been mainly reported in sensory neurons of the peripheral and central nervous system (2, 3). The receptor is activated by a wide variety of exogenous and endogenous physical and chemical stimuli like temperature greater than 42°C; acidic conditions (pH<6); vanilloids, like capsaicin, and allyl isothiocyanate (3). In addition to direct activation, TRPV1 channel activity can also be modulated by inflammatory mediators, such as prostaglandins and bradykinin (4). TRPV1 is involved in the detection and regulation of body temperature, as well as in the sensation of noxious environmental stimuli, like scalding heat and pain. TRPV1 acts as ionotropic endocannabinoid receptor with central neuromodulatory effects and is a prime target for the development of analgesics (5).