Cat. No.: 441 003
Amount: 50 µg
Price:
$375.00
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| Cat. No. 441 003 | 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. |
| Applications | |
| Immunogen | Synthetic peptide corresponding to AA 1778 to 1791 from rat Big2 (UniProt Id: Q7TSU1) |
| Reactivity |
Reacts with: rat (Q7TSU1), mouse (A2A5R2). Other species not tested yet. |
| Specificity | Specific for BIG 2 K.D. validated PubMed: 15198677 |
| Remarks |
IHC: Detects high levels of endogenous BIG 2 protein (e.g. in hippocampus). Regions with low expression levels may be difficult to interpret. |
| Data sheet | 441_003.pdf |
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Brefeldin A-inhibited guanine exchange factor 2 (BIG 2) belongs to the guanine-nucleotide exchange factors (GEFs) for ADP-ribosylation factors (ARFs).
Together with its close relative BIG 1 it is involved in the regulation of membrane traffic through activating ARFs and the recruitment of coat protein complexes, such as the COPI and the AP-1 clathrin adaptor complex.
It has been shown to interact with the beta-subunits of the GABA type-A receptors.