|Cat. No. 436 011||100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.|
WB: 1 : 1000 up to 1 : 2000 gallery
ICC: 1 : 500 up to 1 : 1000 gallery
IHC: 1 : 500 up to 1 : 5000 gallery
IHC-P/FFPE: 1 : 1000 gallery
|Subtype||IgG2a (κ light chain)|
|Immunogen||Recombinant protein corresponding to AA 1 to 276 from mouse Secretagogin (UniProt Id: Q91WD9)|
Reacts with: mouse (Q91WD9), rat (Q6R556), human (O76038).
Other species not tested yet.
|Specificity||Specific for Secretagogin|
Secretagogin, also known as SCGN or SECRET, is a member of the EF-hand (E-helix-loop-F-helix-hand) superfamily of calcium-binding proteins with homology to calbindin-D28k (CALB1) and calretinin (CALB2) which are widely expressed in cells and tissues. Calcium-binding proteins of different subfamilies regulate calcium as a second messenger. Calbindin, calretinin, calmodulin, S-100, parvalbumin and troponin C are members of the low molecular weight calcium-binding protein family.
Interaction between secretagogin and vesicle trafficking proteins, including SNAP25, SNAP23, ARFGAP2, and DOC2A, suggests a possible role for SCGN in neurotransmitter and hormone release.
The secretagogin protein was isolated from pancreatic islets of Langerhans and insulinomas, and shows abundant pancreatic expression and reduced expression in thyroid, adrenal medulla, stomach, small intestine, and colon.