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Secretagogin - 436 011

An EF-hand calcium binding protein
Monoclonal mouse purified IgG
Cat. No.: 436 011
Amount: 100 µg
Price: 415.00 €
Cat. No. 436 011 100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 up to 1 : 2000 gallery  
IP: yes
ICC: 1 : 500 up to 1 : 1000 gallery  
IHC: 1 : 500 up to 1 : 5000 gallery  
IHC-P/FFPE: 1 : 1000 gallery  
Clone 216E6E1
Subtype IgG2a (κ light chain)
Immunogen Recombinant protein corresponding to AA 1 to 276 from mouse Secretagogin (UniProt Id: Q91WD9)
Reactivity Reacts with: mouse (Q91WD9), rat (Q6R556), human (O76038).
Other species not tested yet.
Specificity Specific for Secretagogin
Data sheet 436_011.pdf
Cat. No.: 436 011
Quantity: 100 µg
Price: 415.00 €
Background

Secretagogin, also known as SCGN or SECRET, is a member of the EF-hand (E-helix-loop-F-helix-hand) superfamily of calcium-binding proteins with homology to calbindin-D28k (CALB1) and calretinin (CALB2) which are widely expressed in cells and tissues. Calcium-binding proteins of different subfamilies regulate calcium as a second messenger. Calbindin, calretinin, calmodulin, S-100, parvalbumin and troponin C are members of the low molecular weight calcium-binding protein family.

Interaction between secretagogin and vesicle trafficking proteins, including SNAP25, SNAP23, ARFGAP2, and DOC2A, suggests a possible role for SCGN in neurotransmitter and hormone release.

The secretagogin protein was isolated from pancreatic islets of Langerhans and insulinomas, and shows abundant pancreatic expression and reduced expression in thyroid, adrenal medulla, stomach, small intestine, and colon.