Cat. No.: 436 004
Amount: 100 µl
Price:
$365.00
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| Cat. No. 436 004 |
100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Recombinant protein corresponding to AA 1 to 276 from mouse Secretagogin (UniProt Id: Q91WD9) |
| Reactivity |
Reacts with: rat (Q6R556), mouse (Q91WD9). Other species not tested yet. |
| Data sheet | 436_004.pdf |
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Secretagogin, also known as SCGN or SECRET, is a member of the EF-hand (E-helix-loop-F-helix-hand) superfamily of calcium-binding proteins with homology to calbindin-D28k (CALB1) and calretinin (CALB2) which are widely expressed in cells and tissues. Calcium-binding proteins of different subfamilies regulate calcium as a second messenger. Calbindin, calretinin, calmodulin, S-100, parvalbumin and troponin C are members of the low molecular weight calcium-binding protein family.
Interaction between secretagogin and vesicle trafficking proteins, including SNAP25, SNAP23, ARFGAP2, and DOC2A, suggests a possible role for SCGN in neurotransmitter and hormone release.
The secretagogin protein was isolated from pancreatic islets of Langerhans and insulinomas, and shows abundant pancreatic expression and reduced expression in thyroid, adrenal medulla, stomach, small intestine, and colon.