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Home > Products > 421 002

MDGA1 antibody - 421 002 K.O.

MDGA1 is an IgSF protein involved in neural development
Rabbit polyclonal antiserum
Cat. No.: 421 002
Amount: 200 µl
Price: $360.00
Cat. No. 421 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: not tested yet
IP: not tested yet
ICC: not tested yet
IHC: 1 : 500 gallery  
IHC-P: not tested yet
Immunogen Recombinant protein corresponding to AA 19 to 917 from mouse MDGA1 (UniProt Id: Q0PMG2)
Reactivity Reacts with: mouse (Q0PMG2).
Other species not tested yet.
Specificity K.O. validated PubMed: 35532105
Data sheet 421_002.pdf

References for MDGA1 - 421 002

Functional Neuroligin-2-MDGA1 interactions differentially regulate synaptic GABAARs and cytosolic gephyrin aggregation.
Zeppillo T, Ali H, Ravichandran S, Ritter TC, Wenger S, López-Murcia FJ, Gideons E, Signorelli J, Schmeisser MJ, Wiltfang J, Rhee J, et al.
Communications biology (2024) 71: 1157. 421 002 WB, IHC-Fr; KO verified; tested species: mouse
MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavior.
Toledo A, Letellier M, Bimbi G, Tessier B, Daburon S, Favereaux A, Chamma I, Vennekens K, Vanderlinden J, Sainlos M, de Wit J, et al.
eLife (2022) 11: . 421 002 WB, IP, IHC; KO verified; tested species: mouse
Chronic stress induces depression through MDGA1-Neuroligin2 mediated suppression of inhibitory synapses in the lateral habenula.
Wang X, Wei H, Hu Z, Jiang J, Dong X, Zhu J, Chen H, Brose N, Lipstein N, Xu T, Connor SA, et al.
Theranostics (2025) 155: 1842-1863. 421 002 WB, IHC; KO verified; tested species: mouse
Proteomics analysis of the brain from a Gaucher disease mouse identifies pathological pathways including a possible role for transglutaminase 1.
Blumenreich S, Ben-Yashar DP, Shalit T, Kupervaser M, Milenkovic I, Joseph T, Futerman AH
Journal of neurochemistry (2024) 1681: 52-65. 421 002 WB, IHC; KD verified; tested species: rat
Upregulation of Spinal MDGA1 in Rats After Nerve Injury Alters Interactions Between Neuroligin-2 and Postsynaptic Scaffolding Proteins and Increases GluR1 Subunit Surface Delivery in the Spinal Cord Dorsal Horn.
Li HL, Guo RJ, Ai ZR, Han S, Guan Y, Li JF, Wang Y
Neurochemical research (2024) 492: 507-518. 421 002 WB, IHC; tested species: rat
Cat. No.: 421 002
Amount: 200 µl
Price: $360.00
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