|Cat. No. 418 005||
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Immunoprecipitation (IP); Immunoisolation or pulldown of a target molecule using an antibody. For details and product specific hints, please refer to the ”Remarks” section.', $event)" style="cursor: help;">IP: not tested yet
Immunocytochemistry (ICC) on 4% PFA fixed cells. Immunoreactivity is usually revealed by fluorescence. Some antibodies require special fixation methods. For details, please refer to the “Remarks” section.', $event)" style="cursor: help;">ICC: not tested yet
Immunohistochemistry (IHC) on 4% PFA perfusion fixed tissue with 24h PFA post fixation. Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. Some antibodies require special fixation methods or antigen retrieval steps. For details, please refer to the ”Remarks” section.', $event)" style="cursor: help;">IHC: 1 : 100 up to 1 : 500 gallery
Immunohistochemistry (IHC-P) of formalin fixed, paraffin embedded (FFPE) tissue (some antibodies require special antigen retrieval steps, please refer to the ”Remarks” section). Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate.', $event)" style="cursor: help;">IHC-P: 1 : 100 gallery
|Immunogen||Synthetic peptide corresponding to AA 150 to 162 from mouse Neurotensin/neuromedin N (UniProt Id: Q9D3P9)|
Reacts with: mouse (Q9D3P9), rat (P20068), human (P30990).
Other species not tested yet.
|Specificity||The antibody recognizes Neurotensin. It may crossreact to the unprocessed precursor protein.|
Neurotensin, also referred to as NT or Nts is a 13 amino acid neuropeptide that is processed from a precursor protein that also contains the related neuromedin N. It has a highly conserved C-terminal portion (8–13) which is responsible for its biological activity.
Neurotensin is widely distributed throughout the central nervous system. The highest expression levels are seen in the hypothalamus, amygdala and nucleus accumbens. In the periphery, it is produced by endocrine cells (N cells) of the intestine, where it leads to secretion and smooth muscle contraction.
Neurotensin is involved in the regulation of dopamine pathways, in the maintenance of gut structure and function, and in the regulation of fat metabolism.
Neurotensin has been shown to produce a spectrum of pharmacological effects resembling those of antipsychotic drugs, leading to the suggestion that neurotensin may be an endogenous neuroleptic.