Cat. No.: 402 005
Amount: 50 µg
Price:
$460.00
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| Cat. No. 402 005 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Synthetic peptide corresponding to residues near the carboxy terminus of rat Kv1.2 (UniProt Id: P63142) |
| Reactivity |
Reacts with: rat (P63142), mouse (P63141). Other species not tested yet. |
| Remarks |
WB: Kv1.2 aggregates after boiling, making it necessary to run SDS-PAGE with non-boiled samples. |
| Data sheet | 402_005.pdf |
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A high diversity of K+ channels is formed in the nervous system by heteromeric assembly of subunits encoded by a large number of K+ channel genes. They play an important role in regulating the level of neuronal excitability.
Deletion of Kv 1.2 is lethal in mice and mutations lead to severe consequences including epileptic encephalopathy, intellectual disability and episodic ataxia in humans.