Synaptic Systems - NGF receptor p75

Cat. No.: 396 005

Amount: 50 µg

Price: $465.00

ICC

IHC

IHC-P

Background

NGF (Nerve Growth Factor) receptor p75, also termed p75NTR, NGFR and CD271, is a low affinity neurotrophin receptor and a single-pass type I transmembrane protein. Its ligands include NGF, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and NT-4.
NGF receptor p75 is expressed by many cell types including neurons, Schwann cells, mesenchymal stem/stromal cells, follicular dendritic cells, and various neural crest cells and their tumors.
By mediating neurotrophin signals, the receptor appears to play a role in multiple processes, including neuronal growth, migration, differentiation and cell death during development of the central and peripheral nervous system.
NGF receptor p75 binds its ligands as a homodimer but can also form heterodimers with other receptors such as TrkA, TrkB, TrkC, Nogo receptor and sortilin. The precise multimeric receptor complex formed will determine the ligand being recognized and the biological response to its binding.

1 ) Meeker RB et al., Neural Regen Res (2015)
2 ) Schachtrup C et al., Nat. Neurosci. (2015)
3 ) Liu Z et al., PLoS ONE (2015)
4 ) Tomellini E et al., Cell. Mol. Life Sci. (2014)
5 ) Ovsepian SV et al., Neurobiol. Aging (2013)
6 ) Baeza-Raja B et al., J. Neurosci. (2013)
7 ) Ibáñez CF et al., Trends Neurosci. (2012)
8 ) Underwood CK et al., Int. J. Biochem. Cell Biol. (2008)

Protocols

Cat. No. 396 005	50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H₂O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications	WB: not tested yet IP: not tested yet ICC: 1 : 500 gallery IHC: 1 : 100 up to 1 : 500 gallery IHC-P: 1 : 400 up to 1 : 1000 gallery
Immunogen	Recombinant protein corresponding to AA 266 to 417 from mouse NGF receptor (UniProt Id: Q9Z0W1)
Reactivity	Reacts with: mouse (Q9Z0W1), rat (P07174). Other species not tested yet.
Data sheet	396_005.pdf

NGF receptor p75 antibody - 396 005