|Cat. No. 369 011||100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.|
WB: 1 : 1000 gallery
IP: not tested yet
ICC: not tested yet
IHC: 1 : 500 up to 1 : 5000 gallery
IHC-P/FFPE: 1 : 1000 gallery
|Subtype||IgG2b (κ light chain)|
|Immunogen||Recombinant protein corresponding to AA 1 to 480 from mouse DDC (UniProt Id: O88533)|
Reacts with: mouse (O88533), rat (P14173).
Other species not tested yet.
|Specificity||Specific for DOPA decarboxylase|
DOPA decarboxylase, also referred to as aromatic L-amino acid decarboxylase, AADC or DDC, is the second enzyme in the biosynthesis of dopamine and serotonin. In addition, it is responsible for the synthesis of the trace amines phenylethylamine, p-tyramine, and tryptamine, which are considered to act as neuromodulators.
DDC is expressed in the central nervous system, but has also been detected in several tissues such as liver, kidney, small intestine, adrenal gland and blood vessels.
The inhibition of DDC is used for the treatment of Parkinson's disease.