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Somatostatin-28 - 366 004

A peptide hormone with inhibitory functions
Polyclonal Guinea pig antiserum
Cat. No.: 366 004
Amount: 100 µl
Price: $350.00
Cat. No. 366 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Applications WB: not tested yet
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P/FFPE: 1 : 500 gallery  
Immunogen Synthetic peptide corresponding to AA 89 to 100 from mouse Somatostatin (UniProt Id: P60041)
Reactivity Reacts with: human (P61278), rat (P60042), mouse (P60041).
Other species not tested yet.
Specificity This antibody preferentially recognizes somatostatin-28. It only shows minor cross-reactivity to the unprocessed precursor protein and does not detect somatostatin-14.
Data sheet 366_004.pdf

References for Somatostatin-28 - 366 004

ROCK/PKA inhibition rescues hippocampal hyperexcitability and GABAergic neuron alterations in Oligophrenin-1 Knock-out mouse model of X-linked intellectual disability.
Busti I, Allegra M, Spalletti C, Panzi C, Restani L, Billuart P, Caleo M
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 366 004 IHC; tested species: mouse
Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice.
Zhou H, Su J, Hu X, Zhou C, Li H, Chen Z, Xiao Q, Wang B, Wu W, Sun Y, Zhou Y, et al.
Cell (2020) : . 366 004 IHC; tested species: mouse
Ventral hippocampal projections to the medial prefrontal cortex regulate social memory.
Phillips ML, Robinson HA, Pozzo-Miller L
eLife (2019) 8: . 366 004 IHC; tested species: mouse
Phase-specific surround suppression in mouse primary visual cortex correlates with figure detection behavior based on phase discontinuity.
Li F, Jiang W, Wang TY, Xie T, Yao H
Neuroscience (2018) : . 366 004 IHC; tested species: mouse
Supramammillary Nucleus Afferents to the Dentate Gyrus Co-release Glutamate and GABA and Potentiate Granule Cell Output.
Hashimotodani Y, Karube F, Yanagawa Y, Fujiyama F, Kano M
Cell reports (2018) 2510: 2704-2715.e4. 366 004 IHC; tested species: mouse
Amyloid β induces interneuron-specific changes in the hippocampus of APPNL-F mice.
Sos KE, Mayer MI, Takács VT, Major A, Bardóczi Z, Beres BM, Szeles T, Saito T, Saido TC, Mody I, Freund TF, et al.
PloS one (2020) 155: e0233700. 366 004 EM; tested species: mouse
Cat. No.: 366 004
Quantity: 100 µl
Price: $350.00
ROCK/PKA inhibition rescues hippocampal hyperexcitability and GABAergic neuron alterations in Oligophrenin-1 Knock-out mouse model of X-linked intellectual disability.
Busti I, Allegra M, Spalletti C, Panzi C, Restani L, Billuart P, Caleo M
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 366 004 IHC; tested species: mouse
Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice.
Zhou H, Su J, Hu X, Zhou C, Li H, Chen Z, Xiao Q, Wang B, Wu W, Sun Y, Zhou Y, et al.
Cell (2020) : . 366 004 IHC; tested species: mouse
Ventral hippocampal projections to the medial prefrontal cortex regulate social memory.
Phillips ML, Robinson HA, Pozzo-Miller L
eLife (2019) 8: . 366 004 IHC; tested species: mouse
Phase-specific surround suppression in mouse primary visual cortex correlates with figure detection behavior based on phase discontinuity.
Li F, Jiang W, Wang TY, Xie T, Yao H
Neuroscience (2018) : . 366 004 IHC; tested species: mouse
Supramammillary Nucleus Afferents to the Dentate Gyrus Co-release Glutamate and GABA and Potentiate Granule Cell Output.
Hashimotodani Y, Karube F, Yanagawa Y, Fujiyama F, Kano M
Cell reports (2018) 2510: 2704-2715.e4. 366 004 IHC; tested species: mouse
Amyloid β induces interneuron-specific changes in the hippocampus of APPNL-F mice.
Sos KE, Mayer MI, Takács VT, Major A, Bardóczi Z, Beres BM, Szeles T, Saito T, Saido TC, Mody I, Freund TF, et al.
PloS one (2020) 155: e0233700. 366 004 EM; tested species: mouse
Background
Somatostatin, also referred to as SST, growth hormone-inhibiting hormone or GHIH, is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors. It inhibits the secretion of many important hormones, including insulin, glucagon and somatotropin (also designated growth hormone, or GH).
Somatostatin has two forms, active 14 amino acid and 28 amino acid. They are produced by alternative cleavage of the single precursor protein encoded by this gene.