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EPOR antibody - 358 011

EPOR is the receptor for erythropoietin
Mouse monoclonal purified IgG
Cat. No.: 358 011
Amount: 100 µg
Price: $415.00
Cat. No. 358 011 100 µg purified IgG, lyophilized. Azide was added before lyophilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: yes (see remarks)
IP: yes
ICC: 1 : 1000 gallery  
IHC: not tested yet
IHC-P: not tested yet
Clone 45A3
Subtype IgG2b (κ light chain)
Immunogen Synthetic peptide corresponding to AA 25 to 39 from human EPOR (UniProt Id: P19235)
Reactivity Reacts with: human (P19235).
Other species not tested yet.
Remarks

WB: Less sensitive compared to the rabbit polyclonal antibody (cat. no. 358 003). Only detects EPOR in cells with high expression levels.

Data sheet 358_011.pdf

References for EPOR - 358 011

Widespread expression of erythropoietin receptor in brain and its induction by injury.
Ott C, Martens H, Hassouna I, Oliveira B, Erck C, Zafeiriou MP, Peteri UK, Hesse D, Gerhart S, Altas B, Kolbow T, et al.
Molecular medicine (Cambridge, Mass.) (2015) : . 358 011 ICC
Cat. No.: 358 011
Amount: 100 µg
Price: $415.00
Widespread expression of erythropoietin receptor in brain and its induction by injury.
Ott C, Martens H, Hassouna I, Oliveira B, Erck C, Zafeiriou MP, Peteri UK, Hesse D, Gerhart S, Altas B, Kolbow T, et al.
Molecular medicine (Cambridge, Mass.) (2015) : . 358 011 ICC
Background
The erythropoietin receptor EPOR mediates EPO-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes and triggers the JAK2/STAT5 signaling cascade.
EPO has also been shown to exert potent neuroprotective, neuroregenerative and procognitive functions suggesting EPOR expression in the brain.