|Cat. No. 356 003||50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.|
WB: 1 : 1000 (AP staining) gallery
IP: not tested yet
ICC: 1 : 500 gallery
IHC: 1 : 500 gallery
IHC-P/FFPE: 1 : 500 gallery
|Immunogen||Synthetic peptide corresponding to AA 483 to 493 from mouse MCT1 (UniProt Id: P53986)|
Reacts with: rat (P53987), mouse (P53986).
Other species not tested yet.
|Specificity||Specific for MCT 1.|
|Matching control protein/peptide||356-0P|
The proton-linked transport of monocarboxylates across the plasma membrane plays a critical role in the metabolism and pH regulation of most cells. Fourteen different monocarboxylic acid transporters (MCTs) have been identified, so far. Only four of them (MCT 1-4) have been shown to actively transport the monocarboxylates pyruvate and lactate across the cell membrane.
MCT 1, also referrred to as Slc16 a1, and MCT 2 show differential expression in astrocyte subpopulations and blood vessels in the mammalian brain.
MCT4 is highly expressed in glycolytic cells, such as skeletal muscle fibers, astrocytes, leukocytes, chondrocytes, and some mammalian cell lineages.