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Monocarboxylate transporter 1 antibody - 356 003

MCTs translocate monocarboxylates across the plasma membranes
Rabbit polyclonal purified antibody
Cat. No.: 356 003
Amount: 50 µg
Price: $370.00
Cat. No. 356 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P: 1 : 500 gallery  
Immunogen Synthetic peptide corresponding to AA 483 to 493 from mouse MCT1 (UniProt Id: P53986)
Reactivity Reacts with: rat (P53987), mouse (P53986).
Other species not tested yet.
Specificity Specific for MCT 1.
Matching control protein/peptide 356-0P
Data sheet 356_003.pdf
Cat. No.: 356 003
Amount: 50 µg
Price: $370.00

The proton-linked transport of monocarboxylates across the plasma membrane plays a critical role in the metabolism and pH regulation of most cells. Fourteen different monocarboxylic acid transporters (MCTs) have been identified, so far. Only four of them (MCT 1-4) have been shown to actively transport the monocarboxylates pyruvate and lactate across the cell membrane.
MCT 1, also referrred to as Slc16 a1, and MCT 2 show differential expression in astrocyte subpopulations and blood vessels in the mammalian brain.
MCT4 is highly expressed in glycolytic cells, such as skeletal muscle fibers, astrocytes, leukocytes, chondrocytes, and some mammalian cell lineages.