Cat. No.: 347 404
Amount: 100 µl
Price:
$365.00
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| Cat. No. 347 404 |
100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Synthetic peptide corresponding to residues near the amino terminus of mouse SOX10 (UniProt Id: Q04888) |
| Reactivity |
Reacts with: rat (O55170), mouse (Q04888). Other species not tested yet. |
| Data sheet | 347_404.pdf |
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SRY-Box Transcription Factor 10 (SOX10) belongs to a family of transcription factors characterized by a sequence-specific DNA-binding domain known as the high mobility group-box (HMGB). Members of the SOX family belong to the HMGB subfamily and represent a class of genes expressed during early embryonic development that are involved in cell fate specifications of progenitor cells and terminal cell differentiation in a variety of cell type linages (1-3). SOX10 is a key regulator in early development of neuronal crest cells that give rise to peripheral glial cells (4), melanocytes, cells of the enteric nervous system or chromaffin cells. In the central nervous system SOX10 is present in oligodendrocyte progenitors (OPCs) and remains expressed throughout oligodendrocyte (OL) development and linage. During OL development SOX10 exerts critical functions in terminal OL differentiation and myelin gene expression (5). SOX10 mutations have been reported to Waardenburg syndrome type 4, peripheral demyelinating neuropathy, central demyelinating leukodystrophy, Hirschsprung disease (PCWH), cancer and others.