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Ca2+ channel L-type alpha-1C antibody - 334 002

Rabbit polyclonal antiserum
Cat. No.: 334 002
Amount: 200 µl
Price: $355.00
Cat. No. 334 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
WB: 1 : 1000 (AP staining) (see remarks) gallery  
IP: not tested yet
ICC: not tested yet
IHC: not tested yet
IHC-P: not tested yet
Immunogen Recombinant protein corresponding to AA 1901 to 2169 from rat Ca2+ channel L-type α-1C (Cav1.2) (UniProt Id: P22002)
Reactivity Reacts with: rat (P22002), mouse (Q01815).
Other species not tested yet.

WB: Due to its large size, Ca-channels require special gel-electrophoresis and Western blot protocols for visualization by immunoblotting. Excellent results can be obtained with NuPage TRIS-acetate gels from Invitrogen.
Non-boiled samples are recommended.

Data sheet 334_002.pdf
Cat. No.: 334 002
Amount: 200 µl
Price: $355.00
Voltage gated calcium channels (VGCCs), also referred to as voltage sensitive calcium channels (VSCCs), are present in most excitable cells. They mediate the influx of Ca2+ ions into the cell and trigger the release of neurotransmitters or hormons but are also involved in other calcium dependent processes like metabolism, cell proliferation and cell death.
VGCCs are composed of four subunits (α-1, α-2, β and δ) in a 1:1:1:1 ratio. The α-1C subunit occurs in VGCCs of the L-type which belongs to the high voltage activated group (hva).