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Doublecortin - 326 004

A protein associated with neuronal differentiation
Polyclonal Guinea pig antiserum
Cat. No.: 326 004
Amount: 100 µl
Price: 350.00 €
Cat. No. 326 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: not tested yet
IHC: not recommended
IHC-P/FFPE: 1 : 500 gallery  
Immunogen Recombinant protein corresponding to AA 271 to 366 from mouse Doublecortin (UniProt Id: Q6PGI2)
Reactivity Reacts with: rat (Q9ESI7), mouse (Q6PGI2).
Other species not tested yet.
Specificity Specific for doublecortin.
Data sheet 326_004.pdf
Cat. No.: 326 004
Quantity: 100 µl
Price: 350.00 €
Background
Doublecortin or DCX seems to be required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. Mutations in the gene encoding this protein have been linked to the double cortex syndrome.
Doublecortin is highly expressed in neuronal cells of fetal brain but absent from other tissues. In the adult dentate gyrus it is only expressed in cells contributing to adult neurogenesis.