|Cat. No. 314 111||100 µg purified IgG, lyophilized. Azide was added before lyophilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.|
WB: not tested yet
IP: not tested yet
ICC: not tested yet
IHC: 1 : 500 gallery
IHC-P/FFPE: 1 : 1000 up to 1 : 2000 gallery
|Subtype||IgG1 (κ light chain)|
|Immunogen||Recombinant protein corresponding to AA 1 to 44 from human TauE (UniProt Id: P10636-7)|
Epitop: AA 1 to 44 from human TauE (UniProt Id: P10636-7)
Reacts with: human (P10636-7).
Other species not tested yet.
|Specificity||Specific for tau. This antibody binds phosphorylated and non-phosphorylated tau proteins.|
There are two major classes of heat stable microtubule associated proteins (MAPS): MAP 2 (280 kD), and tau (55-65 kD). Both protein classes are involved in the regulation of microtubule polymerization in cells. Tau is a neuronal protein that mainly localizes to axons. Hyperphosphorylated tau has been shown to be a major element of paired helical filaments in Alzheimer's disease.