|Cat. No. 314 012||200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.|
WB: 1 : 1000 (AP staining) gallery
IP: not tested yet
ICC: not tested yet
IHC: not tested yet
IHC-P/FFPE: 1 : 500 up to 1 : 1000 gallery
|Immunogen||Recombinant protein corresponding to AA 1 to 44 from human TauE (UniProt Id: P10636-7)|
Reacts with: human (P10636).
Other species not tested yet.
|Specificity||Specific for tau.|
The antibody binds phosphorylated and non-phosphorylated tau proteins. This antibody is highly recommended for human tissue.
There are two major classes of heat stable microtubule associated proteins (MAPS): MAP 2 (280 kD), and tau (55-65 kD). Both protein classes are involved in the regulation of microtubule polymerization in cells. Tau is a neuronal protein that mainly localizes to axons. Hyperphosphorylated tau has been shown to be a major element of paired helical filaments in Alzheimer's disease.