Cat. No.: 314 011
Amount: 100 µg
Price:
$415.00
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| Cat. No. 314 011 |
100 µg purified IgG, lyophilized. Azide was added before lyophilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Clone | 248E5 |
| Subtype | IgG2a (κ light chain) |
| Immunogen | Recombinant protein corresponding to the N-terminal half of mouse Tau-D (UniProt Id: P10637-5) |
| Reactivity |
Reacts with: rat (P19332), mouse (P10637). Weaker signal: human (P10636). No signal: zebrafish. Other species not tested yet. |
| Specificity | This antibody binds phosphorylated and non-phosphorylated tau proteins. The sequence used for immunization is present in all splice variants except human TauA (UniProt Id: P10636-3) |
| Matching control protein/peptide | 314-0P |
| Remarks |
For human tissue cat.no. 314 012 and 314 111 are highly recommended. |
| Data sheet | 314_011.pdf |
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There are two major classes of heat stable microtubule associated proteins (MAPS): MAP 2 (280 kD), and tau (55-65 kD). Both protein classes are involved in the regulation of microtubule polymerization in cells. Tau is a neuronal protein that mainly localizes to axons. Hyperphosphorylated tau has been shown to be a major element of paired helical filaments in Alzheimer's disease.