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Tau - 314 003

A microtubule associated protein
Polyclonal rabbit purified antibody
Cat. No.: 314 003
Amount: 50 µg
Price: $450.00
Cat. No. 314 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 1000 gallery  
IHC: yes
IHC-P/FFPE: 1 : 500 gallery  
Immunogen Recombinant protein corresponding to AA 3 to 214 from mouse Tau-D (UniProt Id: P10637-5)
Reactivity Reacts with: rat (P19332), mouse (P10637).
Weaker signal: human (P10636).
No signal: chicken.
Other species not tested yet.
Specificity Specific for tau. Sequence used for immunization is present in all splice variants.
Matching control protein/peptide 314-0P
Remarks

The antibody binds phosphorylated and non-phosphorylated tau proteins.For human tissue antibody 2, cat.no. 314 012, is highly recommended.

Data sheet 314_003.pdf

References for Tau - 314 003

Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy.
Wu T, Dejanovic B, Gandham VD, Gogineni A, Edmonds R, Schauer S, Srinivasan K, Huntley MA, Wang Y, Wang TM, Hedehus M, et al.
Cell reports (2019) 288: 2111-2123.e6. 314 003 WB; tested species: human
Presynaptic NMDA receptors - dynamics and distribution in developing axons in vitro and in vivo.
Gill I, Droubi S, Giovedi S, Fedder KN, Bury LA, Bosco F, Sceniak MP, Benfenati F, Sabo SL
Journal of cell science (2015) 1284: 768-80. 314 003 ICC
The Susd2 protein regulates neurite growth and excitatory synaptic density in hippocampal cultures.
Nadjar Y, Triller A, Bessereau JL, Dumoulin A
Molecular and cellular neurosciences (2015) 65: 82-91. 314 003 ICC
Generation of genetically-modified human differentiated cells for toxicological tests and the study of neurodegenerative diseases.
Schildknecht S, Karreman C, Pöltl D, Efrémova L, Kullmann C, Gutbier S, Krug A, Scholz D, Gerding HR, Leist M
ALTEX (2013) 304: 427-44. 314 003 ICC
Cat. No.: 314 003
Quantity: 50 µg
Price: $450.00
Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy.
Wu T, Dejanovic B, Gandham VD, Gogineni A, Edmonds R, Schauer S, Srinivasan K, Huntley MA, Wang Y, Wang TM, Hedehus M, et al.
Cell reports (2019) 288: 2111-2123.e6. 314 003 WB; tested species: human
Presynaptic NMDA receptors - dynamics and distribution in developing axons in vitro and in vivo.
Gill I, Droubi S, Giovedi S, Fedder KN, Bury LA, Bosco F, Sceniak MP, Benfenati F, Sabo SL
Journal of cell science (2015) 1284: 768-80. 314 003 ICC
The Susd2 protein regulates neurite growth and excitatory synaptic density in hippocampal cultures.
Nadjar Y, Triller A, Bessereau JL, Dumoulin A
Molecular and cellular neurosciences (2015) 65: 82-91. 314 003 ICC
Generation of genetically-modified human differentiated cells for toxicological tests and the study of neurodegenerative diseases.
Schildknecht S, Karreman C, Pöltl D, Efrémova L, Kullmann C, Gutbier S, Krug A, Scholz D, Gerding HR, Leist M
ALTEX (2013) 304: 427-44. 314 003 ICC
Background

There are two major classes of heat stable microtubule associated proteins (MAPS): MAP 2 (280 kD), and tau (55-65 kD). Both protein classes are involved in the regulation of microtubule polymerization in cells. Tau is a neuronal protein that mainly localizes to axons. Hyperphosphorylated tau has been shown to be a major element of paired helical filaments in Alzheimer's disease.