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beta3-Tubulin - 302 311

A tubulin isoform specific for neurons
Monoclonal mouse purified IgG
Cat. No.: 302 311
Amount: 100 µg
Price: 415.00 €
Cat. No. 302 311 100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.
Applications WB: 1 : 5000 up to 1 : 10000 gallery  
IP: not tested yet
ICC: 1 : 500 up to 1 : 2000 gallery  
IHC: 1 : 5000 up to 1 : 10000 gallery  
IHC-P/FFPE: 1 : 2000 gallery  
Clone 356E3D10
Subtype IgG2a (κ light chain)
Immunogen Synthetic peptide corresponding to AA 443 to 450 from mouse β3-Tubulin (UniProt Id: Q9ERD7)
Reactivity Reacts with: rat (Q4QRB4), mouse (Q9ERD7).
Other species not tested yet.
Specificity Specific for β3-tubulin.
Matching control protein/peptide 302-3P
Data sheet 302_311.pdf
Cat. No.: 302 311
Quantity: 100 µg
Price: 415.00 €
Background

Microtubules are involved in a wide variety of cellular activities ranging from mitosis and transport events to cell movement and the maintainance of cell shape (1).
Tubulin itself is a globular protein which consists of two polypeptides, α-tubulin and β-tubulin. α- and β-tubulin dimers are assembled to 13 protofilaments that form a microtubule of 25 nm diameter (1).
Class III β-tubulin is abundant in the central and peripheral nervous systems (CNS and PNS) where it is prominently expressed during fetal and postnatal development (2).
It is widely used as a neuronal marker in normal and neoplastic tissues but has also been reported to be expressed in certain tumours of non-neuronal origin (3).