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beta3-Tubulin - 302 306

A tubulin isoform specific for neurons
Polyclonal chicken IgY fraction
Cat. No.: 302 306
Amount: 200 µl
Price: $350.00
Cat. No. 302 306 200 µl antibody, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 up to 1 : 10000 (AP staining) gallery  
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P/FFPE: 1 : 500 gallery  
Immunogen Synthetic peptide corresponding to AA 443 to 450 from mouse β3-Tubulin (UniProt Id: Q9ERD7)
Reactivity Reacts with: human, rat, mouse.
Other species not tested yet.
Specificity Specific for β3-tubulin.
Matching control protein/peptide 302-3P
Data sheet 302_306.pdf

References for beta3-Tubulin - 302 306

nNOS-CAPON blockers produce anxiolytic effects by promoting synaptogenesis in chronic stress-induced animal models of anxiety.
Zhu LJ, Shi HJ, Chang L, Zhang CC, Si M, Li N, Zhu DY
British journal of pharmacology (2020) 17716: 3674-3690. 302 306 ICC; tested species: mouse
Essential role for InSyn1 in dystroglycan complex integrity and cognitive behaviors in mice.
Uezu A, Hisey E, Kobayashi Y, Gao Y, Bradshaw TW, Devlin P, Rodriguiz R, Tata PR, Soderling S
eLife (2019) 8: . 302 306 ICC; tested species: mouse
Cat. No.: 302 306
Quantity: 200 µl
Price: $350.00
nNOS-CAPON blockers produce anxiolytic effects by promoting synaptogenesis in chronic stress-induced animal models of anxiety.
Zhu LJ, Shi HJ, Chang L, Zhang CC, Si M, Li N, Zhu DY
British journal of pharmacology (2020) 17716: 3674-3690. 302 306 ICC; tested species: mouse
Essential role for InSyn1 in dystroglycan complex integrity and cognitive behaviors in mice.
Uezu A, Hisey E, Kobayashi Y, Gao Y, Bradshaw TW, Devlin P, Rodriguiz R, Tata PR, Soderling S
eLife (2019) 8: . 302 306 ICC; tested species: mouse
Background

Microtubules are involved in a wide variety of cellular activities ranging from mitosis and transport events to cell movement and the maintainance of cell shape (1).
Tubulin itself is a globular protein which consists of two polypeptides, α-tubulin and β-tubulin. α- and β-tubulin dimers are assembled to 13 protofilaments that form a microtubule of 25 nm diameter (1).
Class III β-tubulin is abundant in the central and peripheral nervous systems (CNS and PNS) where it is prominently expressed during fetal and postnatal development (2).
It is widely used as a neuronal marker in normal and neoplastic tissues but has also been reported to be expressed in certain tumours of non-neuronal origin (3).