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beta3-Tubulin - 302 302

A tubulin isoform specific for neurons
Polyclonal rabbit antiserum
Cat. No.: 302 302
Amount: 200 µl
Price: $350.00
Cat. No. 302 302 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 up to 1 : 10000 (AP staining) gallery  
IP: yes
ICC: 1 : 1000 up to 1 : 5000 gallery  
IHC: 1 : 200 up to 1 : 500 gallery  
IHC-P/FFPE: 1 : 500 gallery  
Immunogen Synthetic peptide corresponding to AA 443 to 450 from mouse β3-Tubulin (UniProt Id: Q9ERD7)
Reactivity Reacts with: human (Q13509), rat (Q4QRB4), mouse (Q9ERD7).
Other species not tested yet.
Specificity Specific for β3-tubulin.
Matching control protein/peptide 302-3P
Data sheet 302_302.pdf

References for beta3-Tubulin - 302 302

Missense mutation of Fmr1 results in impaired AMPAR-mediated plasticity and socio-cognitive deficits in mice.
Prieto M, Folci A, Poupon G, Schiavi S, Buzzelli V, Pronot M, François U, Pousinha P, Lattuada N, Abelanet S, Castagnola S, et al.
Nature communications (2021) 121: 1557. 302 302 WB; tested species: mouse
The Actin Nucleator Cobl Is Critical for Centriolar Positioning, Postnatal Planar Cell Polarity Refinement, and Function of the Cochlea.
Haag N, Schüler S, Nietzsche S, Hübner CA, Strenzke N, Qualmann B, Kessels MM
Cell reports (2018) 249: 2418-2431.e6. 302 302 WB; tested species: mouse
Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum.
Kuijpers M, Kochlamazashvili G, Stumpf A, Puchkov D, Swaminathan A, Lucht MT, Krause E, Maritzen T, Schmitz D, Haucke V
Neuron (2021) 1092: 299-313.e9. 302 302 ICC; tested species: mouse
Decellularized skeletal muscles display neurotrophic effects in three-dimensional organotypic cultures.
Raffa P, Scattolini V, Gerli MFM, Perin S, Cui M, De Coppi P, Elvassore N, Caccin P, Luni C, Urciuolo A
Stem cells translational medicine (2020) : . 302 302 ICC; tested species: rat
Generation of oligodendrocytes and establishment of an all-human myelinating platform from human pluripotent stem cells.
García-León JA, García-Díaz B, Eggermont K, Cáceres-Palomo L, Neyrinck K, Madeiro da Costa R, Dávila JC, Baron-Van Evercooren A, Gutiérrez A, Verfaillie CM
Nature protocols (2020) : . 302 302 ICC; tested species: human
Generation and characterization of human induced pluripotent stem cells lines from four patients diagnosed with schizophrenia and one healthy control.
Stock R, Vogel S, Mau-Holzmann UA, Kriebel M, Wüst R, Fallgatter AJ, Volkmer H
Stem cell research (2020) 48: 101961. 302 302 ICC; tested species: human
Basal glucocorticoid receptor activation induces proliferation and inhibits neuronal differentiation of human induced pluripotent stem cell-derived neuronal precursor cells.
Nürnberg E, Horschitz S, Schloss P, Meyer-Lindenberg A
The Journal of steroid biochemistry and molecular biology (2018) : . 302 302 ICC; tested species: human
hsa-let-7c miRNA Regulates Synaptic and Neuronal Function in Human Neurons.
McGowan H, Mirabella VR, Hamod A, Karakhanyan A, Mlynaryk N, Moore JC, Tischfield JA, Hart RP, Pang ZP
Frontiers in synaptic neuroscience (2018) 10: 19. 302 302 ICC; tested species: human
Neuron-astrocyte interaction enhance GABAergic synaptic transmission in a manner dependent on key metabolic enzymes.
Kaczor P, Rakus D, Mozrzymas JW
Frontiers in cellular neuroscience (2015) 9: 120. 302 302 ICC
Impact of preconditioning with retinoic acid during early development on morphological and functional characteristics of human induced pluripotent stem cell-derived neurons.
Horschitz S, Matthäus F, Groß A, Rosner J, Galach M, Greffrath W, Treede RD, Utikal J, Schloss P, Meyer-Lindenberg A
Stem cell research (2015) 151: 30-41. 302 302 ICC
Neuroplastin expression is essential for hearing and hair cell PMCA expression.
Lin X, Brunk MGK, Yuanxiang P, Curran AW, Zhang E, Stöber F, Goldschmidt J, Gundelfinger ED, Vollmer M, Happel MFK, Herrera-Molina R, et al.
Brain structure & function (2021) : . 302 302 IHC; tested species: mouse
Mechanism of disease and therapeutic rescue of Dok7 congenital myasthenia.
Oury J, Zhang W, Leloup N, Koide A, Corrado AD, Ketavarapu G, Hattori T, Koide S, Burden SJ
Nature (2021) : . 302 302 IHC; tested species: mouse
Vezatin is Required for the Maturation of the Neuromuscular Synapse.
Koppel N, Friese MB, Cardasis HL, Neubert TA, Burden SJ
Molecular biology of the cell (2019) : mbcE19060313. 302 302 IHC; tested species: mouse
BMP/SMAD Pathway Promotes Neurogenesis of Midbrain Dopaminergic NeuronsIn Vivoand in Human Induced Pluripotent and Neural Stem Cells.
Jovanovic VM, Salti A, Tilleman H, Zega K, Jukic MM, Zou H, Friedel RH, Prakash N, Blaess S, Edenhofer F, Brodski C, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 387: 1662-1676. 302 302 IHC; tested species: mouse
Cat. No.: 302 302
Quantity: 200 µl
Price: $350.00
Missense mutation of Fmr1 results in impaired AMPAR-mediated plasticity and socio-cognitive deficits in mice.
Prieto M, Folci A, Poupon G, Schiavi S, Buzzelli V, Pronot M, François U, Pousinha P, Lattuada N, Abelanet S, Castagnola S, et al.
Nature communications (2021) 121: 1557. 302 302 WB; tested species: mouse
The Actin Nucleator Cobl Is Critical for Centriolar Positioning, Postnatal Planar Cell Polarity Refinement, and Function of the Cochlea.
Haag N, Schüler S, Nietzsche S, Hübner CA, Strenzke N, Qualmann B, Kessels MM
Cell reports (2018) 249: 2418-2431.e6. 302 302 WB; tested species: mouse
Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum.
Kuijpers M, Kochlamazashvili G, Stumpf A, Puchkov D, Swaminathan A, Lucht MT, Krause E, Maritzen T, Schmitz D, Haucke V
Neuron (2021) 1092: 299-313.e9. 302 302 ICC; tested species: mouse
Decellularized skeletal muscles display neurotrophic effects in three-dimensional organotypic cultures.
Raffa P, Scattolini V, Gerli MFM, Perin S, Cui M, De Coppi P, Elvassore N, Caccin P, Luni C, Urciuolo A
Stem cells translational medicine (2020) : . 302 302 ICC; tested species: rat
Generation of oligodendrocytes and establishment of an all-human myelinating platform from human pluripotent stem cells.
García-León JA, García-Díaz B, Eggermont K, Cáceres-Palomo L, Neyrinck K, Madeiro da Costa R, Dávila JC, Baron-Van Evercooren A, Gutiérrez A, Verfaillie CM
Nature protocols (2020) : . 302 302 ICC; tested species: human
Generation and characterization of human induced pluripotent stem cells lines from four patients diagnosed with schizophrenia and one healthy control.
Stock R, Vogel S, Mau-Holzmann UA, Kriebel M, Wüst R, Fallgatter AJ, Volkmer H
Stem cell research (2020) 48: 101961. 302 302 ICC; tested species: human
Basal glucocorticoid receptor activation induces proliferation and inhibits neuronal differentiation of human induced pluripotent stem cell-derived neuronal precursor cells.
Nürnberg E, Horschitz S, Schloss P, Meyer-Lindenberg A
The Journal of steroid biochemistry and molecular biology (2018) : . 302 302 ICC; tested species: human
hsa-let-7c miRNA Regulates Synaptic and Neuronal Function in Human Neurons.
McGowan H, Mirabella VR, Hamod A, Karakhanyan A, Mlynaryk N, Moore JC, Tischfield JA, Hart RP, Pang ZP
Frontiers in synaptic neuroscience (2018) 10: 19. 302 302 ICC; tested species: human
Neuron-astrocyte interaction enhance GABAergic synaptic transmission in a manner dependent on key metabolic enzymes.
Kaczor P, Rakus D, Mozrzymas JW
Frontiers in cellular neuroscience (2015) 9: 120. 302 302 ICC
Impact of preconditioning with retinoic acid during early development on morphological and functional characteristics of human induced pluripotent stem cell-derived neurons.
Horschitz S, Matthäus F, Groß A, Rosner J, Galach M, Greffrath W, Treede RD, Utikal J, Schloss P, Meyer-Lindenberg A
Stem cell research (2015) 151: 30-41. 302 302 ICC
Neuroplastin expression is essential for hearing and hair cell PMCA expression.
Lin X, Brunk MGK, Yuanxiang P, Curran AW, Zhang E, Stöber F, Goldschmidt J, Gundelfinger ED, Vollmer M, Happel MFK, Herrera-Molina R, et al.
Brain structure & function (2021) : . 302 302 IHC; tested species: mouse
Mechanism of disease and therapeutic rescue of Dok7 congenital myasthenia.
Oury J, Zhang W, Leloup N, Koide A, Corrado AD, Ketavarapu G, Hattori T, Koide S, Burden SJ
Nature (2021) : . 302 302 IHC; tested species: mouse
Vezatin is Required for the Maturation of the Neuromuscular Synapse.
Koppel N, Friese MB, Cardasis HL, Neubert TA, Burden SJ
Molecular biology of the cell (2019) : mbcE19060313. 302 302 IHC; tested species: mouse
BMP/SMAD Pathway Promotes Neurogenesis of Midbrain Dopaminergic NeuronsIn Vivoand in Human Induced Pluripotent and Neural Stem Cells.
Jovanovic VM, Salti A, Tilleman H, Zega K, Jukic MM, Zou H, Friedel RH, Prakash N, Blaess S, Edenhofer F, Brodski C, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) 387: 1662-1676. 302 302 IHC; tested species: mouse
Background

Microtubules are involved in a wide variety of cellular activities ranging from mitosis and transport events to cell movement and the maintainance of cell shape (1).
Tubulin itself is a globular protein which consists of two polypeptides, α-tubulin and β-tubulin. α- and β-tubulin dimers are assembled to 13 protofilaments that form a microtubule of 25 nm diameter (1).
Class III β-tubulin is abundant in the central and peripheral nervous systems (CNS and PNS) where it is prominently expressed during fetal and postnatal development (2).
It is widely used as a neuronal marker in normal and neoplastic tissues but has also been reported to be expressed in certain tumours of non-neuronal origin (3).