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Home > Products > 295 002

Myelin basic protein antibody - 295 002

MBP is a major component of the myelin sheath
Rabbit polyclonal antiserum
Cat. No.: 295 002
Amount: 200 µl
Price: $355.00
Cat. No. 295 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: not tested yet
IHC: 1 : 500 (see remarks) gallery  
IHC-P: 1 : 200 gallery  
Immunogen Synthetic peptide corresponding to AA 105 to 115 from rat MBP (UniProt Id: P02688)
Reactivity Reacts with: human (P02686), rat (P02688), mouse (P04370).
Other species not tested yet.
Specificity Specific for MBP. Epitope is present in all splice variants.
Matching control protein/peptide 295-0P
Remarks

IHC: Heat-mediated antigen retrieval (in citrate buffer pH 6) is required for immunohistochemical staining.
Data sheet 295_002.pdf

References for Myelin basic protein - 295 002

Immunosignals of Oligodendrocyte Markers and Myelin-Associated Proteins Are Critically Affected after Experimental Stroke in Wild-Type and Alzheimer Modeling Mice of Different Ages.
Michalski D, Keck AL, Grosche J, Martens H, Härtig W
Frontiers in cellular neuroscience (2018) 12: 23. 295 002 IHC; tested species: mouse
Cat. No.: 295 002
Amount: 200 µl
Price: $355.00
Immunosignals of Oligodendrocyte Markers and Myelin-Associated Proteins Are Critically Affected after Experimental Stroke in Wild-Type and Alzheimer Modeling Mice of Different Ages.
Michalski D, Keck AL, Grosche J, Martens H, Härtig W
Frontiers in cellular neuroscience (2018) 12: 23. 295 002 IHC; tested species: mouse
WB
IHC
IHC-P
Background
The myelin sheath is a multi-layered membrane composed of several proteins like PLP, claudin 11 and myelin basic protein (MBP) which is specific for the nervous system. MBP functions as an insulator and increases the velocity of axonal impulse conduction.
MBP can be subdivided into the classic group consisting of isoforms 4 to 14 and the non-classic group of MBP comprising the Golli MBPs (isoforms 1 to 3). Differential splicing events and optional posttranslational modifications give rise to a wide spectrum of isomers with potentially specialized functions.
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