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ADAR1 p150 antibody - 293 003 K.O.

ADAR1 p150 is an adenosine deaminase acting on RNA
Rabbit polyclonal purified antibody
Cat. No.: 293 003
Amount: 50 µg
Price: $380.00
Cat. No. 293 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: not tested yet
IHC: not recommended
IHC-P: not tested yet
Immunogen Recombinant protein corresponding to AA 1 to 248 from mouse ADAR1p150 (UniProt Id: Q99MU3)
Reactivity Reacts with: rat (P55266), mouse (Q99MU3).
Other species not tested yet.
Specificity Specific for ADAR1 p150. K.O. validated PubMed: 31956894
Data sheet 293_003.pdf

References for ADAR1 p150 - 293 003

Regulation of the double-stranded RNA response through ADAR1 licenses metaplastic reprogramming in gastric epithelium.
Sáenz JB, Vargas N, Cho CJ, Mills JC
JCI insight (2022) 73: . 293 003 WB, IHC, IHC-P; tested species: mouse
ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation.
de Reuver R, Verdonck S, Dierick E, Nemegeer J, Hessmann E, Ahmad S, Jans M, Blancke G, Van Nieuwerburgh F, Botzki A, Vereecke L, et al.
Nature (2022) 6077920: 784-789. 293 003 WB; KO,KD verified; tested species: mouse
ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation.
de Reuver R, Dierick E, Wiernicki B, Staes K, Seys L, De Meester E, Muyldermans T, Botzki A, Lambrecht BN, Van Nieuwerburgh F, Vandenabeele P, et al.
Cell reports (2021) 366: 109500. 293 003 WB; tested species: mouse
An internal deletion of ADAR rescued by MAVS deficiency leads to a minute phenotype.
Bajad P, Ebner F, Amman F, Szabó B, Kapoor U, Manjali G, Hildebrandt A, Janisiw MP, Jantsch MF
Nucleic acids research (2020) : . 293 003 WB; KO verified; tested species: mouse
Cat. No.: 293 003
Amount: 50 µg
Price: $380.00
WB
WB