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ADAR 1 p150 - 293 003

Adenosine deaminase acting on RNA
Polyclonal rabbit purified antibody
Cat. No.: 293 003
Amount: 50 µg
Price: $370.00
Cat. No. 293 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: not tested yet
IHC: not recommended
IHC-P/FFPE: not tested yet
Immunogen Recombinant protein corresponding to AA 1 to 248 from mouse ADAR1p150 (UniProt Id: Q99MU3)
Reactivity Reacts with: rat (P55266), mouse (Q99MU3).
Other species not tested yet.
Specificity Specific for ADAR 1 p150. K.O. PubMed: 31956894
Data sheet 293_003.pdf

References for ADAR 1 p150 - 293 003

An internal deletion of ADAR rescued by MAVS deficiency leads to a minute phenotype.
Bajad P, Ebner F, Amman F, Szabó B, Kapoor U, Manjali G, Hildebrandt A, Janisiw MP, Jantsch MF
Nucleic acids research (2020) : . 293 003 WB; KO verified; tested species: mouse
Cat. No.: 293 003
Quantity: 50 µg
Price: $370.00
An internal deletion of ADAR rescued by MAVS deficiency leads to a minute phenotype.
Bajad P, Ebner F, Amman F, Szabó B, Kapoor U, Manjali G, Hildebrandt A, Janisiw MP, Jantsch MF
Nucleic acids research (2020) : . 293 003 WB; KO verified; tested species: mouse
Background
ADARs bind to double stranded RNA regions and deaminate adenosine residues to inosine. An inosine is interpreted as a guanosine by the translation machinery leading to alterations of codons.
In addition microRNAs involved in posttranscriptional regulation are modulated through ADAR mediated RNA editing.
Three members of the ADAR gene family (ADAR 1-3) have been identified in vertebrates. In addition, two isoforms of ADAR 1 are synthesized by translation initiation at alternative start codons, an interferon-inducible, cytoplasmic 150-kDa protein (p150) and a constitutive, nuclear 110-kDa protein (p110).